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Biomedical subjects

T Jack

Publications and source records attributed to T Jack.

28 records · Page 2Linked to original sources
PubMed1988

A novel, tissue-specific, Drosophila homeobox gene.

The homeobox gene family of Drosophila appears to control a variety of position-specific patterning decisions during embryonic and imaginal development. Most of these patterning decisions determine groups of cells on the anterior-posterior axis of the Drosophila germ band. We have isolated a novel homeobox gene from Drosophila, designated H2.0. H2.0 has the most diverged homeobox so far characterized in metazoa, and, in contrast to all previously isolated homeobox genes, H2.0 exhibits a tissue-specific pattern of expression. The cells that accumulate transcripts for this novel gene correspond to the visceral musculature and its anlagen.

Amino Acid Sequence↗
PubMed1986

Plasma ascorbic acid levels in Nigerian children of Niger delta region of Nigeria.

The plasma level of ascorbic acid has been used as a measure of both dietary intake and body reserve of the vitamin. In growing children, ascorbic acid is particularly important for the enhancement of the formation of bone matrix. Although the occurrence of scurvy in the tropics is exceptional and rarely reported in children, available data on plasma ascorbic acid level in children especially in Nigeria is almost non-existent. An earlier report found the mean plasma ascorbic level for Nigerian children to be 0.25mg/100ml. Using a modification of Kuther's method, blood plasma from 50 subjects was analysed for plasma ascorbic acid concentration. The subjects were primary school children in the Niger Delta Region of Nigeria, both sexes, aged between 8 and 12 years. Their mean plasma ascorbic acid level was found to be 0.71mg/100ml with a standard deviation of 0.118mg/100ml.68% of them were normal and 32% subnormal. None was deficient. There was no relationship among the children, between plasma ascorbic level and sex, age, weight or environment.

Ascorbic Acid↗
PubMed1982

Binding of an inert, cationic osmium probe to walls of Bacillus subtilis.

X-ray fluorescence spectroscopy and electron microscopy of unstained specimens have been used to study the binding of chloropentaammineosmium(III) chloride to isolated walls of Bacillus subtilis. Native walls bound 0.220 mumol of the osmium probe per mg (dry weight) of walls, whereas walls which were chemically treated to neutralize the available carboxylate groups of the peptidoglycan bound only 0.040 mumol. Teichoic acid-depleted walls bound 0.210 mumol. Thin sections of all wall types showed the osmium probe to be scattered throughout the wall matrix as a small staining deposit. The results support the idea that the metal ion-binding capacity of these walls is mediated by the available carboxylate groups in the wall fabric.

Bacillus subtilis↗
PubMed1979

Lipase synthesis in hydrocarbon fermentation.

A study was undertaken to establish conditions and relationships for the production of lipases during hydrocarbon fermentation. A culture of Candida lipolytica was isolated by a kerosene enrichment technique from oil-soaked soil and this microbe was used to study the production of lipase on a kerosene-mineral salts medium. The optimum pH, medium, and temperature for lipase synthesis were established and the properties of the isolated enzyme in terms of its activity and lipid specificity were studied.

Candida↗
PubMed1979

Acute reactions to mega ascorbic acid therapy in malignant disease.

Three cases are described, 2 of Hodgkin's disease and a further case of bronchial carcinoma, where high dosage ascorbic acid treatment appeared to be associated with the development of potentially dangerous symptoms. It is suggested that mega ascorbic acid therapy should be given with caution in malignant disease, with a slow build-up over several days to high levels of dosage.

Adult↗
PubMed1975

The orthomolecular treatment of cancer. III. Reticulum cell sarcoma: double complete regression induced by high-dose ascorbic acid therapy.

The response of a patient with histologically proven reticulum cell sarcoma to no treatment other than large doses of ascorbic acid is described. At the time of first diagnosis, the disease was widely disseminated, and a very dramatic regression of all parameters of disease activity was induced by the continuous administration of large doses of ascorbic acid. Reduction in dosage some months later coincided with reactivation of the disease process. The reinstitution of regular high-dose ascorbic acid therapy induced a second complete remission. The case report is illustrated by serial radiographs. The significance of the therapeutic response is briefly discussed in relation to general schemes of cancer management.

Adult↗
PubMedDate not supplied

Occupational injury fatalities--1994.

Factory workers caught in machinery and construction workers falling or struck by huge beams are images that typically come to mind when considering serious hazards in the workplace. But these types of events account for only a small portion of job-related fatalities each year. Transportation-related fatalities, along with assaults and violent acts during work, made up almost two-thirds of the 6,588 fatal work injuries recorded in 1994. The majority of job-related fatal work events occurred on the streets and highways and in public buildings and in areas such as grocery stores and parking lots. Today the most deadly jobs are found in outdoor occupations such as fishing and timber cutting. In fact, in all 10 jobs studied that have high fatality rates, most workers are affected by severe weather conditions while driving on highways, performing farm chores and working at construction sites. Highway crashes are the primary cause of trucker fatalities; falls are the leading cause of death for roofers, construction laborers and structural metal workers, while tractor rollovers account for a third of farm worker fatalities. Another deadly contributing factor for some workers is homicide, which accounted for 16 percent of job-related fatalities in 1994. Workers most at risk are those who work alone, work late at night and handle varying sums of money. Taxicab drivers are the most susceptible and have a work injury fatality rate nine times higher than the national rate of 5 deaths per 100,000 workers. Others at high risk of homicide include gas station cashiers, grocery store employees and workers in retail eating and drinking establishments. Although the risk of a fatal injury at work varies greatly by occupation and industry, no one is immune. For prevention, workers and employers need to know what jobs are risky, what equipment is dangerous and what activities are hazardous. They also should understand that a fatal incident can happen to anyone.

Accidents, Occupational↗