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T J Zuber

Publications and source records attributed to T J Zuber.

41 records · Page 3Linked to original sources
PubMed1981

Quantitative assessment of steroid hormone binding sites by thaw-mount autoradiography.

A procedure for the quantitative assessment of nuclear receptors for steroid hormones--and other substances--in individual cells is presented. Thaw-mount autoradiography, a procedure developed earlier in our laboratory, is utilized. The silver grain yield (specific activity) is 16.6 disintegrations per silver as determined fo tritium in guinea pig uterine tissues. An integrated formula is presented and applied for 3H-estradiol, 3H-diethylstilbestrol, and 3H-aldosterone in sampled tissue. A comparison with data derived from the literature that are based on the homogenization of whole uteri and biochemical analysis shows comparable values wtih the autoradiographic data if the latter are pooled. The pooled ata indicated 12-14,00 molecules of 3H-estradiol per uterine nucleus, while subpopulations of target cells vary between 5,000 and 28,000 per nucleus.

Animals↗
PubMedDate not supplied

Chondrodermatitis nodularis chronica helicis.

Chondrodermatitis nodularis chronica helicis is a painful nodule of the external ear. These uncommon lesions are most often encountered on the helix in white men older than 40 years, although they also rarely occur on the antihelix in women. The lesions frequently present with exquisite tenderness that interferes with sleep. While the cause of this dermal inflammatory process is not known, long-term trauma or sun damage may play a role. Recurrences often complicate treatment if all sites of inflammation are not eradicated. Surgical treatment is generally recommended, either by wide excision or by deep shave and treatment of the underlying cartilage.

Cartilage Diseases↗