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Biomedical subjects

T J Yoo

Publications and source records attributed to T J Yoo.

At least 91 records · Page 5Linked to original sources
PubMed1979

Successful re-treatment with cis-dichlorodiammineplatinum(II) after apparent allergic reactions.

Allergic or anaphylactic-like reactions have been reported with cis-dichlorodiammineplatinum(II) (CDDP) administration. We have seen two reactions among 50 patients treated in a phase II trial of CDDP. Both patients were successfully rechallenged after diphenhydramine pretreatment, and therapy was continued. In vivo and in vitro studies performed in one patient included negative skin tests, negative histamine release assay, negative lymphocyte stimulation studies, and normal total serum IgE. We conclude that some apparent allergic reactions occurring with CDDP may have a non-allergic etiology, and treatment may be successfully continued in selected patients.

Adult↗
PubMed1978

Studies of the radioallergosorbent test and the lymphocyte stimulation index in symptomatic ragweed pollenosis.

We followed 47 ragweed hay fever patients (not on immunotherapy) through a ragweed season by means of clinical evaluation and symptom scores. The radioallergosorbent test (RAST) and lymphocyte stimulation index (LSI) were done to determine their reliability as predictors of clinical symptomatology. Symptom scores of 10 or above, denoting at least moderate daily symptoms, occurred in 36 patients (80%). Preseasonally, RAST class 2 or above was found in 34 patients (75%), of whom 29 patients (64%) had symptom scores of 10 or above. At that time, LSI was elevated in about 50% of the patients. Patients in RAST class 3 had the highest LSI as a group. Seasonal exposure boosted the LSI in 50% of the patients, whereas 25% were unchanged and 25% showed a decrease. The results suggest that neither RAST nor LSI are reliable predictors of clinical severity in ragweed pollenosis.

Adult↗
PubMed1977

In vitro inhibition of tritiated thymidine uptake in Morris hepatoma cells by normal rat liver extract: a possible liver chalone.

A phosphate-buffered saline extract of normal rat liver tissue almost completely inhibited DNA synthesis in Buffalo rat Morris hepatoma 7777 cells in vitro. This effect was tissue-specific because it did not occur with extracts of kidney, spleen, heart, lung, muscle, and hepatoma. The liver extracts did not inhibit in vitro human prostate carcinoma or phytohemagglutinin-stimulated human and rat peripheral blood lymphocyte cultures. The addition of 10% fetal calf serum in the incubation medium had no effect on this inhibition. We determined that doses of liver extract that inhibit thymidine incorporation were not toxic inasmuch as treated cells remained viable, as indicated by trypan blue exclusion. The liver extract may thus contain a cell-specific mitotic inhibitor, a chalone for hepatoma cells.

Animals↗
PubMed1977

A study of dust-induced lymphocyte blastogenesis.

The in vitro measurement of dust allergen-stimulated lymphocyte blastogenesis by the incorporation of H3-thymidine can be a useful measurement for the evaluation of the cellular immune function in dust allergy patients. Dust allergy patients receiving immunotherapy had lower lymphocyte responses than those not receiving immunotherapy. Additionally, dust allergy patients as a whole showed higher lymphocyte stimulation indices than normal control.

Allergens↗
PubMed1977

A new allergen from the perienteric fluid of Ascaris suum with respect to charges.

A NEW ALLERGEN WITH PI in the 6.0 region was obtained from the perienteric fluid of Ascaris suum through isoelectric focusing techniques. This new allergen shows strong allergenicity, at a concentration of 10(-9) microgram/ml, in rats passively sensitized with the reaginic antiserum produced against Ascaris perienteric fluid.

Allergens↗
PubMed1977

Reaginic immune response to tree pollen antigen in LBN rats.

The immunogenicity and cross-antigenicity of ten common tree pollen allergens were studied in LBN rats. The rats produced IgE antibodies to each of the allergens used (maple, willow, poplar, ash, oak, sycamore, hickory, walnut, birch, and elm), yet the allergens had extremely limited cross-reactivity. The possible explanation for the limited cross-antigenicity is discussed.

Animals↗
PubMed1977

Family study HLA antigen and Ir gene linkage in ragweed and dust allergy.

A family was studied for HLA antigen Ir-gene linkage in ragweed and dust allergy by clinical history, skin test, mixed lymphocyte cultures, lymphocyte culture for cellular immunity to antigen E and dust allergens, RAST assay for ragweed and dust antigens and HLA typing. These results confirm previous observations that ragweed Ir genes are linked to the inheritance of the HLA complex. The Ir genes may map at some distance from the closely linked HLA and MLC genes. It is also of interest that Ir genes for dust allergy in this family appear closely associated with ragweed genes. The set of twins with identical HLA complexes but different expression of presumably identical Ir genes will bear watching.

Antibody Formation↗