Search PubMed⌕ Search

Biomedical subjects

T J Mosher

Publications and source records attributed to T J Mosher.

22 records · Page 2Linked to original sources

Renal medullary cystic disease: assessment by MRI.

Medullary cystic disease is an important cause of renal failure in adolescent patients. Imaging plays a primary role in the diagnosis of this entity as cysts are characteristically seen in the renal medulla and corticomedullary junction with normal to small sized kidneys. Imaging studies that do not use intravenous contrast or ionizing radiation are particularly useful given the young age of these patients and presence of renal failure. In this case, we demonstrate the imaging findings of medullary cystic disease by MRI.

Adult↗

Advanced MR imaging techniques for evaluation of the heart and great vessels.

A "one-stop shop" for evaluating cardiac disease with magnetic resonance (MR) imaging is progressing toward clinical reality and promises to have a major effect on the care of patients with cardiac disease. T1-weighted conventional spin-echo imaging gated to the cardiac cycle yields good anatomic detail but requires long imaging times and provides only static images of a single cardiac phase. Fast MR imaging with electrocardiographically (ECG) gated, low-flip-angle, segmented k-space gradient-recalled-echo (GRE) sequences provides excellent image quality with sufficiently high temporal resolution to "freeze" cardiac motion. Segmented k-space sequences improve on standard ECG-gated GRE sequences by allowing many cardiac phases, or frames of a cine sequence, to be imaged in a single breath hold with prospective cardiac gating. As commercial implementations of segmented k-space imaging become more widely available, the applications of this technique are expanding from research protocols to include many clinical applications in the heart and great vessels. Such applications include evaluation of vascular anatomy (coronary angiography, aortic disease, aberrant vessels, vascular access), cardiac anatomy (congenital anomalies, right ventricular dysplasia, constrictive pericarditis, valvular function), myocardial perfusion, and myocardial wall motion.

Cardiovascular Diseases↗

An evaluation of the accuracy and reliability of ethylene oxide diffusion badge monitors.

Ethylene oxide (EO) gas is widely used in hospitals to sterilize certain moisture- and heat-sensitive materials. Based on scientific studies indicating its potential as a human carcinogen and mutagen, and the possible genotoxic, reproductive, neurologic, and sensitization hazards associated with EO exposure, the Occupational Safety and Health Administration has recently lowered the permissible exposure limit (PEL) from 50 ppm to 1 ppm as an 8-hour time-weighted average (TWA). This standard also established an "action level" of 0.5 ppm for an 8-hour TWA, below which employers are exempted from such requirements as periodic employee exposure monitoring or medical surveillance. These much lower concentrations of EO in air now place greater demands upon the analytical techniques used to monitor exposure of hospital personnel to EO. In this study, the capabilities of five EO diffusion monitors were examined in the TWA concentration range of 0.25-3.7 ppm. Both accuracy and precision were tested by exposing these devices simultaneously to measured concentrations of EO in a stainless steel exposure chamber. Temperature and humidity conditions were controlled, as was the flow rate of the gases across the sampling areas of the diffusion monitors. All of the monitors tested were sensitive enough to measure EO at the new PEL level, but in this laboratory investigation only one type of monitoring badge was able to meet the National Institute for Occupational Safety and Health criteria of +/- 25% overall system accuracy at the 95% confidence level in the exposure range of 0.5-2.0 X the OSHA PEL.

Chromatography, Gas↗