Biomedical subjects

T J Meek

Publications and source records attributed to T J Meek.

5 recordsLinked to original sources

PubMed1989

Treatment of Pseudomonas aeruginosa auricular perichondritis with oral ciprofloxacin.

Pseudomonas aeruginosa auricular perichondritis can be a serious and expensive postoperative infection requiring prolonged hospitalization and intravenous administration of antibiotics. Oral antimicrobial agents have not been effective in the treatment of serious P. aeruginosa infections. Recently completed clinical trials have shown that oral ciprofloxacin, one of the new fluoroquinolone antimicrobials, is effective in the treatment of certain P. aeruginosa infections. We report two cases of P. aeruginosa auricular perichondritis successfully treated as outpatients with oral ciprofloxacin. This article also reviews the salient features of the new fluoroquinolones and their impact on antimicrobial therapy of serious skin and skin-structure infections.

Administration, Oral↗

PubMed1984

Herpes gestationis in blacks.

To our knowledge, only two cases of herpes gestationis (HG) have been previously reported in black patients. We describe herein two black women with confirmed HG. Both had typical historical and clinical features of the disease. Direct immunofluorescence microscopy demonstrated complement deposition along the dermoepidermal junction in both women. Where HLA typing was possible (in one patient), the combination of HLA-DR3 and HLA-DR4 was found. In addition, anti-HLA-DR2 antibodies were present in serum samples taken from this patient. The occurrence of the HLA-DR3-DR4 combination has been reported to be greatly increased in whites with HG (43%, as compared with a 3% incidence in control subjects). The HLA-DR4 antigen is uncommon in American blacks, which may explain the infrequent occurrence of HG in this population. The occurrence of the DR2 antigen is increased in the husbands of women with HG, and this increase is most pronounced in the husbands of patients with the DR3-DR4 combination. The occurrence of positive immunofluorescence microscopy findings, together with the presence of a rare histocompatibility antigen combination previously associated with HG and the presence of anti-DR2 antibodies in the serum of one of our patients all suggest that HG is pathogenically identical in both blacks and whites.

Adult↗

PubMed1980

Melanoma in the dermatologist's office.

Data about melanomas seen in a private dermatologist's office during a fifteen year period were evaluated as to size, location, stage, and histologic level of the lesions, and sex and survival of the patients. Forty-three melanomas were seen in forty-one patients. Only four patients (9 percent) died as a result of their melanomas. All patients were at clinical stage 1 of the disease. Thirty-two lesions were smaller than 1.6 cm. Twenty-four (56 percent) of the lesions were of the superficial spreading type. Apparently, patients with melanomas seek advice at a dermatologist's office when their disease is at an earlier stage of development than do patients generally seen in other types of medical settings. A plea is made to examine patients yearly for pigmented lesions. The number of melanomas seen per 10,000 patient-visits rose during the fifteen year period.

Adolescent↗

PubMed1978

Fixed drug eruptions to tetracyclines.

We observed 11 cases of fixed drug eruption to tetracyclines. Two cases were in a mother and her adult son, and two patients experienced fading of their lesions while continuing to take 1 g of the drug per day. Several patients were cross-reactive to different salts.

Adolescent↗

PubMed1977

Acne treatment: a comparative efficacy trial of clindamycin and tetracycline.

Tetracycline was compared to clindamycin as adjunctive therapy in the treatment of moderate to moderately severe acne under double-blind controlled conditions. Both antibiotics were efficacious and differences were not appreciable. Lesion counts of both comedones and pustules were reduced and clinical improvement was noted in the majority of subjects. Side effects were not a problem. The place of clindamycin in the therapeutic armamentarium of the dermatologist is discussed.

Acne Vulgaris↗