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T J Mason

Publications and source records attributed to T J Mason.

95 records · Page 6Linked to original sources
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High-throughput purity estimation and characterisation of synthetic peptides by electrospray mass spectrometry.

High-throughput analysis for purity and molecular weight determination of synthetic peptides including characterisation of any peptidic byproducts arising from synthesis is described. The data from electrospray mass spectrometry are processed with an algorithm that calculates the contribution of the target peptide and each of the identifiable contaminants to the total ionizable material in a sample of synthetic peptide. All essential data are obtained by one instrumental technique in < 3 min per sample. The technique has distinct advantages in the rapid analysis of the many hundreds of peptides/peptidomimetics required in systematic quantitative structure-activity relationship and other investigations.

Algorithms↗
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Pukeora directions.

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Health Facility Planning↗
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Cancer mortality in United States counties with metal electroplating industries.

A survey of cancer mortality from 1950 to 1969 was conducted in U.S. counties where greater than 0.1% of the county's population was employed in the metal electroplating and coating industry. The mortality rates for several cancers, particularly of the esophagus and larynx, in these counties were higher than rates for a group of control counties with comparable demographic characteristics. Further study is needed to determine if these patterns result for worker exposures to substances such as caustic acids and alkalies, metals, and organic solvents commonly used in this industry.

Adult↗
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Multipin technology in the preparation and screening of peptide libraries.

Peptide libraries are relatively new sources of enormous numbers of unique compounds, fodder for the mill of drug discovery programs. Their enormous diversity derives from vast numbers of combinations of a small number of monomers (Geysen et al., 1986). For example, a complete hexapeptide library synthesized from just 10 monomers (amino acids) has one million unique compounds in it. In principle, other types of combinatorial libraries can have equally vast numbers of members; for example, the monomers can be N-acyl glycines, giving rise to the so-called "peptoids" (Simon et al., 1992); or the monomers could be monosaccharides or nucleotides.

Biotechnology↗