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Biomedical subjects

T J Hoon

Publications and source records attributed to T J Hoon.

23 records · Page 2Linked to original sources
PubMed1987

Contribution of clinical pharmacists to cefazolin utilization.

Cefazolin utilization guidelines were established by representatives of major participants in the patient care process in a 520-bed teaching hospital. Patients admitted to certain hospital units and placed on cefazolin therapy were concurrently monitored for compliance with guidelines by clinical pharmacists (experimental group), while patients admitted to similar units were not monitored for guideline compliance (control group). When therapy, in the experimental group, was deemed noncompliant to the established guidelines, the pharmacist alerted the physician and made recommendations to correct the deficiency. The percent increase in compliance with guidelines attributed to clinical pharmacist intervention was then measured. Clinical pharmacy monitoring for the experimental group increased the rate of compliance with guidelines and decreased the overall cost of patient care. The projected net annual savings in cefazolin cost was calculated to be $7,913.00.

Anti-Bacterial Agents↗
PubMed1987

Liquid chromatography and fluorescence polarization immunoassay methods compared for measuring flecainide acetate in serum.

We analyzed 99 patients' serum samples for concentrations of a new antiarrhythmic agent, flecainide acetate, by fluorescence polarization immunoassay (FPIA) and "high-performance" liquid chromatography (HPLC). Within-day and between-day coefficients of variation at concentrations in the low and high ends of the therapeutic range were less than 7% for HPLC and less than 9% for FPIA. There was no statistical difference in the mean (+/- SD) concentrations of the clinical serum samples measured by the two methods (607 +/- 334 micrograms/L by HPLC, 602 +/- 344 micrograms/L by FPIA), but results by each differed by a mean of 0.13%. FPIA and HPLC measurements correlated significantly (r = 0.98, P less than 0.05), and were linearly related (slope = 0.970, intercept = 13 micrograms/L) as assessed by orthogonal regression. Both assay methods produced similar concentration measurements and were sufficiently accurate and precise to be used in therapeutic drug monitoring.

Anti-Arrhythmia Agents↗
PubMed1986

The pharmacodynamic and pharmacokinetic differences of the D- and L-isomers of verapamil: implications in the treatment of paroxysmal supraventricular tachycardia.

There is increasing interest in defining the pharmacodynamic and pharmacokinetic characteristics of drugs that are marketed as racemic mixtures. Verapamil is one such drug that is commercially available as a mixture of D- and L-isomers. The L-isomer of verapamil has a greater-negative inotropic, negative chronotropic, and negative dromotropic potency than the D-isomer. The values for fraction unbound in serum, distribution volume, and systemic clearance are substantially greater for the L-isomer after intravenous dosing. After oral dosing, the D-isomer achieves peak plasma concentrations five times greater than the L-isomer. The pharmacodynamic and pharmacokinetic characteristics of each isomer are reviewed. The differences in the concentrations of the D- and L-isomers after oral vs intravenous dosing may contribute to the relatively lower efficacy of orally administered verapamil in the treatment of PSVT.

Administration, Oral↗
PubMedDate not supplied

Performance of an electrocardiographic analysis system: implications for pharmacodynamic studies.

The performance of a digital data-acquisition and -analysis system in measuring cardiac complex intervals was compared with manual measurements in 10 healthy subjects. A data set of 500 cardiac complexes was created from lead II electrocardiographic samples from each subject. Intervals were measured to the nearest 5 msec by hand and to the nearest 1 msec by the analysis system. Automated measurements of the RR interval and QRS duration exhibited no bias and median absolute errors of 3 msec. Measurements of the PR interval exhibited a significant bias (18 msec) that accounted for the majority of the imprecision (19 msec). A small but significant bias (4 msec) was found in the measurement of the QT duration with a median absolute error of 12 msec. The traditional method of averaging the values of 10 consecutive complexes provided results similar to individual complex measurements. The automated analysis of cardiac intervals can produce data that are suitable for pharmacodynamic studies.

Adult↗