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Biomedical subjects

T J Gallagher

Publications and source records attributed to T J Gallagher.

At least 55 records · Page 3Linked to original sources

A new, microprocessor device for mean airway pressure measurement.

Accurate assessment of mean airway pressure (PAW) during controlled mechanical ventilation (CMV), intermittent mandatory ventilation (IMV), continuous positive airway pressure (CPAP), and expiratory positive airway pressure (EPAP) or spontaneous PEEP (sPEEP), or combinations thereof can be electronically determined with the Novametrix Pneumogard Model 1230 Ventilator Monitor. Measurement of PAW provides information on the interactions of airway pressure hemodynamics and respiratory function.

Computers↗

A simplified method of independent lung ventilation.

The authors have developed a new method for independent lung ventilation (ILV). After lung isolation with a double-lumen endotracheal tube, one ventilator with two subunits controls independent lung tidal volume (VT) and PEEP to each lung. A modified bird Mark 2 ventilator serves as a pneumatically powered timer activating two sets of parallel inspiratory-expiratory flow cartridges. Intermittent mandatory ventilation (IMV) with PEEP or controlled mechanical ventilation (CMV) with PEEP can be provided. This ventilator has been successfully used to treat patients with severe unilateral disease. Desirable qualities include simplicity of operation, availability of parts, and low cost.

Adolescent↗

Goal-directed therapy of acute respiratory failure.

Three hundred fifteen consecutive patients with acute respiratory failure (ARF) were treated to the same end point. Based on blood gas determination, positive end-expiratory pressure (PEEP) was added in incremental steps to either maintain or reduce intrapulmonary shunt to 15%. Mean optimal PEEP level was 15.3 +/- 9.2 cm H2O. Duration of PEEP was 4.0 days, and mechanical ventilatory support was necessary 2.2 days. Overall mortality was 28% (88/315); 1% (3/315) died or refractory failure. The final optimal PEEP level did not correlate with length of interventions, fluid requirements, mortality, or final attained shunt value. Goal-directed therapy was not only effective in achieving a low mortality from acute respiratory failure, but permits a valid comparison between patients of the severity of respiratory dysfunction. That comparison is based on magnitude and length of interventions required to attain preselected therapeutic end points.

Acute Disease↗

Metabolic alkalosis complicating weaning from mechanical ventilation.

Metabolic alkalosis was identified and confirmed as a precipitator of acute hypercapnea. As a result, weaning from mechanical ventilator therapy was delayed. Correction of alkalosis followed by reduction of PCO2 confirmed the compensatory mechanism during alkalosis, and weaning from intermittent mandatory ventilation then proceeded at an appropriate rate.

Acetazolamide↗

Easy coronal scans.

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Tomography, X-Ray Computed↗

Evalution of mechanical ventilators in a hyperbaric environment.

Four mechanical ventilators, the pneumatic Emerson, IMV bird, Urgency bird, and the Modified Mark 2 bird were tested in a hyperbaric chamber at depths up to 165 ft of sea water (FSW). All failed except the Emerson, which is the only machine recommended for chamber use at this time.

Evaluation Studies as Topic↗

Posttraumatic pulmonary insufficiency: a treatable disease.

Posttraumatic pulmonary insufficiency was treated using positive end-expiratory pressure (PEEP), intermittent mandatory ventilation, and cardiovascular monitoring and support. These were begun when intrapulmonary shunt exceeded 15% and before development of hypoxemia despite high inspired oxygen fractions; or retention of CO2; or infiltrative changes on roentgenogram. Of 39 patients treated, 28 required aggressive intervention with levels of PEEP up to 40 cm H2O and support of cardiovascular function with fluids, blood, and ionitropic agents. Those sustaining blunt trauma required the same level of interventions as those with penetrating trauma, but for a significantly longer time. All had reversal of respiratory failure with reduction of shunt to 15%. There were no deaths from respiratory failure or the treatment modalities. Early aggressive treatment for all cases was successful and allowed differentiation of the severity of the original insult.

Blood Gas Analysis↗