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Biomedical subjects

T Iwase

Publications and source records attributed to T Iwase.

At least 181 records · Page 10Linked to original sources
PubMed1990

A variant of calcifying epithelial odontogenic tumor with Langerhans cells.

A variant of calcifying epithelial odontogenic tumor (CEOT) with Langerhans cells is reported. Compared to a typical CEOT, the tumor islands of this case were thin and composed of a small number of polyhedral epithelial cells. Almost no calcification of homogeneous eosinophilic materials was observed. In addition, clear cells which structurally corresponded to Langerhans cell were intermingled in the epithelial islands. These cells stain positively for S-100 protein, lysozome, MT 1, LN-3 and OKT 6 antibodies, but not for keratin antibody. Electronmicroscopic examination revealed the rod-shaped and racket-shaped structures called Birbeck's granules in the cytoplasm of these clear cells. Our observations indicate a variant case of CEOT with Langerhans cells in tumor nests.

Adult↗
PubMed1990

Immunoglobulin A (IgA) polymerization sites in human immunocytes: immunoelectron microscopic study.

The cytoplasmic affinity of polymeric IgA for secretory component (SC) and the expression of joining (J) chain were examined in pokeweek mitogen (PWM)-stimulated human peripheral blood lymphocytes (PBL) to determine, on the ultrastructural level, the polymerization sites of human IgA. SC-binding was found in 5.7% of transformed PBL on day 7 of culture; SC-binding was observed in a high proportion of IgA-producing cells. A low proportion of IgM-producing cells also bound to SC, while there was virtually no SC-binding by IgG-producing cells. A high proportion of IgA- and IgM-producing cells expressed intracellular J chain, while approximately half of the IgG-producing cells were positive for J chain. The number of J chain-positive cells exceeded the number of SC-binding cells among transformed PBL on day 7 of culture. Immunoelectron microscopic study of the sites of SC-binding, and of IgA and J chain expression, revealed that polymerization of human IgA and the addition of J chain occur in the perinuclear space and endoplasmic reticulum, prior to immunoglobulin secretion.

Adult↗
PubMed1990

[Study of breast cancers during pregnancy and lactation].

From breast cancer cases that were mastectomized between 1970 and 1987 at the Cancer Institute Hospital, 43 breast cancers during phases of pregnancy and lactation (pregnancy 11 cases, lactation 32 cases) have been analyzed. Taking the patient's age and the calendar-year at the time of diagnosis into account, we collected 43 cases as controls and compared the result. It was found that breast cancers during pregnancy and lactation metastasized to the lymph nodes at the same frequency as in the control cases, in lymph node-positive cases and in tumors of the same size the metastases involved more lymph nodes than in the control cases. Further, the survival rate of breast cancers during pregnancy and lactation was poorer in the lymph node-positive cases than in the controls. Therefore, we have concluded that pregnancy and lactation promote the progress of a metastatic cancer.

Adult↗
PubMed1990

[The study of endotoxin levels in portal venous system in liver cirrhosis].

In the patients with liver cirrhosis, endotoxin levels were measured in portal venous system by the toxicolor method and the mechanism of endotoxemia in the peripheral vein was studied. On endotoxin levels in portal venous system, the superior mesenteric vein had the highest level. Endotoxemia was observed most frequently in the superior mesenteric vein (78%), and 50% in the truncal portal vein and 55% in the peripheral vein. The hepatic "endotoxin extraction ratio" which is considered to reflect the Kupffer cell function of clearing endotoxin and the severity of cirrhosis were not related each other. On the other hand, in view of the extrahepatic portal shunt, systemic endotoxemia appeared more frequently in the patients with the other collaterals than the esophageal varices. Therefore, it was concluded that systemic endotoxemia in liver cirrhosis was related with the type of extrahepatic portal collaterals.

Aged↗
PubMed1989

Immunocytochemical demonstration of amelogenins and enamelins secreted by ameloblasts during the secretory and maturation stages.

Rabbit polyclonal antibodies against bovine amelogenins and enamelins which did not show any cross-reaction were raised, and ultrathin sections of rat incisors were examined by the protein A-gold and ABC methods. The immunoreactivity of amelogenins was found in dense granules in the intercellular spaces between preameloblasts, and later over the fine- and coarse-textured material. The immunoreactivity was present over the cell organelles associated with the secretory pathway, as well as pale and dark lysosomes of the presecretory and secretory ameloblasts. Here the enamel was immunolabeled in the intercrystal spaces. The immunoreactivity in multivesicular bodies was stronger in preameloblasts than in secretory ameloblasts. In the region of second ruffle-ended ameloblasts at the maturation stage, the immunolabeling was intense in the ruffled-border, but in the rough endoplasmic reticulum and Golgi apparatus, the immunolabeling was much weaker than at the secretory stage. The immunolabeling for enamelins showed essentially the same intracellular topographical pattern as that for amelogenins by the secretory stage, but was weaker. The immunoreactivity was found mainly attached to the enamel crystals. Double immunostaining of amelogenins and enamelins revealed that both immunoreactivities were present over the same cell organelles associated with secretion and lysosomal systems. It is suggested that the presecretory and secretory ameloblasts are actively involved in the secretion, degradation and resorption of enamel proteins, and that multivesicular bodies and lysosomes in the cells take part in these processes. Ameloblasts are considered to be related to the synthesis of enamelins.

Ameloblasts↗
PubMed1988

Immunoglobulin subclasses in chronic tonsillitis.

The distribution and proportion of immunoglobulin-producing cells in palatine tonsil, including IgG and IgA subclasses, have been examined in chronic tonsillitis using an immunofluorescence method. Results obtained indicate that the percentage ratios of IgG1:IgG2:IgG3:IgG4 were 53.1:35.9:4.7:6.3. Higher percentages of IgG1- and lower percentages of IgG2-producing cells were found among 3 types of tonsillitis. Proportional ratios of IgA1:IgA2 were approximately 80:20, and a slight elevation of IgA2-producing cells was observed in chronic tonsillitis.

Antibody-Producing Cells↗
PubMed1987

Significance of intimal tears in the mechanism of luminal enlargement in percutaneous transluminal coronary angioplasty: correlation of histologic and angiographic findings in postmortem human hearts.

Transluminal coronary angioplasty was performed in 17 coronary arteries with stenotic lesions of 15 postmortem human hearts. Morphologic changes of dilated vessels were examined angiographically and histologically. Angiographic evidence of coronary dissection was present in 8 (47%) of the 17 vessels. Histologic examination showed that intimal, medial, and adventitial tears were present in 17 (100%), 11 (65%), and one (6%) of the 17 vessels, respectively. In vessels with angiographic evidence of coronary dissection, the tear extended to more than one fourth of the circumference of the vessel. The tear was histologically demonstrated also in vessels which had no angiographic evidence of coronary dissection. Circumferential extension of the tear was greater in women than in men. There were no significant relationships between severity of the tear and histologic or angiographic characteristics of the target lesions. These results suggest that intimal or medial tears may frequently occur also in clinical cases treated with percutaneous transluminal coronary angioplasty and may be necessary for the success of the procedure.

Aged↗
PubMed1987

Periapical cemental dysplasia with multiple lesions.

3 cases of periapical cemental dysplasia with multiple lesions in both maxilla and mandible are reported. All 3 patients are middle-aged females with an average age of 47 years; histological examination of excised tissue revealed that the lesions were composed of fibrous connective tissue and cementum-like hard tissue. The location of the teeth affected were mainly in the premolar-molar regions. A subsequent literature survey of previously described Japanese cases of periapical cemental dysplasia disclosed a similar distribution pattern for the location of PCD lesions. This evidence indicates that the occurrence sites of lesions of periapical cemental dysplasia is predominantly in premolar-molar regions in Japan, contrary to the location of PCD in other ethnic groups.

Adult↗
PubMed1987

Clinical effects of intravenous diltiazem hydrochloride on renal hemodynamics.

We administered diltiazem HCl i.v. (0.05 mg/kg in bolus followed by 0.01 mg/kg/min for 45 min), and determined the changes in blood pressure (BP), glomerular filtration rate (GFR), renal blood flow (RBF), total renal resistance, urinary volume (UV), urinary sodium (UNa) and potassium excretion, urea and osmolar clearance, and tubular reabsorption ratio of sodium (TRNa%). The serum concentration of diltiazem achieved was similar to the maximum level after a single oral dose of 120 mg. GFR and RBF were measured by i.v. infusion of sodium thiosulfate and sodium rho-amino-hippurate, respectively, as indicators. The subjects included 12 cases of essential hypertension (EH), 10 of chronic glomerular nephritis (CGN) with hypertension, 12 of CGN without hypertension, 12 of ischemic heart disease (IHD), and 10 of normotensive controls. BP decreased in hypertensives but not in normotensives. In patients with EH, GFR and RBF increased markedly (by 25.3 +/- 33.8% and 30.7 +/- 39.5%, respectively). In patients with IHD, GFR increased slightly by 9.8 +/- 17.6%, whereas in patients with CGN with hypertension, GFR decreased by -4.3 +/- 14.3%. No significant change of these indices was observed in normal subjects and in patients with CGN without hypertension. UV and UNa increased and TRNa% decreased in all groups. Urea and osmolar clearance increased in almost every group.

Adult↗