[Studies on the effects of simultaneous administrations of propranolol and glucagon on the release of growth hormone (author's transl)].
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Adolescent↗
Biomedical subjects
T Itatsu
Publications and source records attributed to T Itatsu.
Effect of somatostatin on neurotensin-induced glucagon release and hyperglycemia.
Administration of neurotensin to dogs resulted in rises in circulating blood glucose, glucagon and insulin levels, the rise in glucagon being more pronounced than that in insulin. Infusion of somatostatin along with neurotensin suppressed glucagon and insulin responses to neurotensin and prevented the rise in blood glucose levels. These results suggest that the hyperglycemia seen after neurotensin is due to neurotensin stimulation of glucagon release over insulin release.
Animals↗
[Insulin radioimmunoassay by solid phase method].
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Evaluation Studies as Topic↗
[Proceedings: Serum dopamine beta hydroxylase activity in various diseases].
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Adrenal Gland Neoplasms↗
Effect of ethionine on carbohydrate and lipid metabolism.
In ethionine-treated rats, the ATP content of adipose tissue was not decreased whereas in liver it was drastically reduced to about one-fifth of the control level. Shortly after the injection of ethionine, hepatic glycogen was depleted and the blood glucose concentration fell from 120 to 80 mg/100 ml. This was followed by a two- to threefold elevation of the plasma fatty acid level. Hepatic glucose-6-phosphate was decreased and was not elevated by administration of 2 mmoles of glucose unless ATP was partially restored to normal levels. When hepatic ATP was decreased, the disappearance of [(14)C]glucose from the blood and its incorporation into glycogen and glyceride-glycerol and the incorporation of [3-(14)C]pyruvate into glyceride-glycerol were reduced. 6 hr after ethionine injection the plasma triglyceride level fell but there was no significant change in the liver triglyceride concentration, but by 24 hr it had increased markedly. Lipogenesis in adipose tissue was depressed in vivo, possibly due to decreased glycerol-3-phosphate concentrations. A marked decrease of glycerol-3-phosphate in both liver and adipose tissue was noted. Administration of glucose effectively depressed plasma free fatty acid concentration and elevated the glycerol-3-phosphate levels. Ethionine injection to fasted animals further depressed the blood glucose and elevated the plasma free fatty acid level.
Adenosine Triphosphate↗