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Biomedical subjects

T Ioku

Publications and source records attributed to T Ioku.

3 recordsLinked to original sources

[Hepatectomy and intra-arterial infusion chemotherapy for hepatic metastasis of colorectal cancer].

We experienced 339 patients with primary colorectal cancer in our department. In the present study 69 cases of liver metastasis were examined for their treatments and effects. One-year, 3-year and 5-year survival rates were 49.2%, 16.2% and 6.8% in the 69 patients, respectively. Fourteen patients underwent hepatic resection plus hepatic artery infusion therapy. The overall survival rates at 1, 3 and 5 years were favorable: 88.3%, 55.6% and 29.6%, respectively. Three patients with H3 liver metastasis underwent hepatic resection plus hepatic artery infusion therapy. One patient is alive 29 months after operation, one died 25 months after operation, and the other is alive 8 months after operation. Thirteen patients with H3 liver metastasis from colorectal cancer underwent hepatic artery infusion therapy, and the one-year survival rate was 30.8%. None of the H3 patients without hepatic artery infusion therapy survived more than one year.

Antimetabolites, Antineoplastic↗

[Evaluation of clinical usefulness of 11C-methionine positron emission tomography (11C-MET-PET) as a tool for liver functional imaging].

We studied 11C-MET-PET in 17 clinical cases, 10 patients with obstructive jaundice and 7 normal volunteers, and analyzed its efficacy for the evaluation of hepatic functional reserve in major hepatectomy candidates. Differential absorption ratio (DAR) of 11C was compared to the hepatic protein synthesis rate (HPS), which is measured as the incorporation rate of 3H-labeled leucine in protein fraction, using needle biopsied liver specimen obtained from each hepatic segment. In the cases of normal liver function, DAR was well correlated with HPS. Also in jaundice cases with two exceptions, low HPS segment was demonstrated as low DAR segment. Consequently, MET-PET images could clearly provide functional liver imaging. After injection to 11C-MET, the increase in rate of radioactivity of 11C in plasma protein fraction was higher in jaundice cases than in normal volunteers, which is in accord with the results of our former study that cholestatic liver has accelerated protein synthesis rate. In summary, since 11C-MET-PET could demonstrate liver functional imaging, it might be a possible tool for liver function assessment in major hepatectomy candidates.

Carbon Radioisotopes↗

[Noblesse oblige].

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Neurosurgery↗