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T Inoue

Publications and source records attributed to T Inoue.

At least 1,117 records · Page 62Linked to original sources
PubMed1997

[Acculturation attitudes and mental health of international students in their first year].

The aim of the present study was to show relationship between acculturation attitudes and mental health of international students in their first year in Japan. Of 53 new international students at a university, 50 (36 male and 14 female), 19.2 years old on average, completed a questionnaire in May (one month after the arrival), October (six months later), and March of the following year (the last month of the first academic year). The questionnaire consisted of two parts: Acculturation Attitude Scale and SCL-90-R Mental Health Scale. The former was based on Kim (1988) and measured four types of acculturation attitudes: Integration, Assimilation, Separation, and Marginalization (Berry, 1990, 1992; Berry, Trimble, & Olmedo, 1986). Results indicated that effects of acculturation attitudes on mental health of international students became clear in the last month of their first year. It is argued that helping students' integration attitude has beneficial effects on their mental health.

Acculturation↗
PubMed1997

Prosthodontic treatment for patients with large mandibular defects; porous hydroxyapatite grafts.

It is difficult for both prosthodontists and their patients with large marginal defects to achieve a satisfactory prosthodontic result, because retention, support, and stability of the prosthesis are limited and recovery of esthetics is unsatisfactory owing to large mandibular defects. Alveolar ridge augmentation therapy is performed to compensate for such problems. We have experienced a good prognosis of prosthodontic treatment for over 10 years in two patients with large marginal defects of the partially edentulous mandible, who had undergone grafting of porous hydroxyapatite blocks to their bone defects. It has been reported that porous hydroxyapatite blocks are unsuitable for edentulous patients, because the mucosa covering the hydroxyapatite block is too thin and delicate to support dentures. We, therefore, designed the denture to prevent concentration of occlusal stress on the mucosa. In both of these two cases, we achieved recovery of occlusal function and esthetics by affixing denture to the large marginally resected defect augmented with a graft of porous hydroxyapatite block.

Adult↗
PubMed1997

Spatial chain patterns of intra-urban migration.

"This research analyzes quantitatively the track of individual chain-type migration of many residents to determine how they move in response to changes in their lives, i.e., whether there is spatial regularity on the chain patterns of intra-urban migration. The study area for this research is the industrial city of Yokkaichi, Japan. The study helps us to understand the state of intra-urban migration at the non-aggregate level for all residents during a 15-year period. Special attention is given to the age at which a resident relocates, and to the interval between two successive movements, i.e., the stationary period."

Age Factors↗
PubMed1997

Modulation of E-cadherin expression in TPA-induced cell motility: well-differentiated human adenocarcinoma cells move as coherent sheets associated with phosphorylation of E-cadherin-catenin complex.

We previously presented a two-dimensional cell motility assay using L-10, a highly metastatic variant of the human rectal adenocarcinoma cell line RCM-1, as a motility model of tumor cells of epithelial origin. In this model, L-10 cells moved outward from the cell islands mainly as a localized coherent sheet of cells when stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA). Electronmicroscopic study of the migrating cell sheets revealed that wide intercellular gaps had developed at the lower portion of the cells, allowing them to extend leading lamellae, whereas close cell-cell contacts remained at the upper portion of the cells. In the present study, the mechanism involved in this localized modulation of cell-cell adhesion at the lower portion of the cells was investigated with special reference to E-cadherin expression. E-cadherin immunostaining, which was demonstrated using an anti-E-cadherin mAb, HECD-1, was decreased in migrating L-10 cell sheets. Apparently, however, E-cadherin was involved in the sheet formation of migrating cells because simultaneous or sequential treatment with TPA and HECD-1 inhibited sheet formation and caused scattering of migrating cells. With immunoelectron microscopic study, E-cadherin immunoreactivity was confined to the upper portion of migrating cells and lost at the lower portion. The level of E-cadherin and alpha-catenin expression was not altered by TPA treatment, although tyrosine phosphorylation of E-cadherin and catenins increased 1.6- to 1.9-fold. We propose that cells are released from cell-cell adhesion only at the lower portion of the cells via phosphorylation of the E-cadherin-catenin complex when stimulated with TPA. This change allows the cells to extend leading lamella and thus move together as coherent sheets (cohort migration).

Adenocarcinoma↗
PubMed1997

[The effects of cervical epidural anesthesia on epidural somatosensory evoked potentials and phrenic nerve activities].

We have investigated the effects of cervical epidural anesthesia on-phrenic nerve activity (PNA), and epidural somatosensory evoked potential (SSEP) elicited by stimulation of the radial nerve in pentobarbital anesthetized cats. PNA was suppressed significantly to 72% of control value 10 min after injection of 1% lidocaine and recovered to control value within 30 min. Following 2% lidocaine injection, PNA tended to be more suppressed than with 1% lidocaine to 57% and recovered to control value within 30 min. Peak latencies of P1, N1, P2, N2, and P3 before injection of 1% lidocaine were 1.05 (0.24), 1.20 (0.11), 1.51 (0.20), 1.56 (0.34), 2.71 (0.33) (msec (SD)), respectively. Though these latencies did not increase after injection of 1% lidocaine, injection of 2% lidocaine increased them significantly and these elevations continued for 120 min. The amplitude of N2 increased significantly after injection of 1% lidocaine and the amplitude of N2 and N2-P3 increased after injection of 2% lidocaine. These results indicate that 2% lidocaine blocked the sensory nerve and the effects continued much longer than the depression of PNA by cervical epidural anesthesia.

Action Potentials↗
PubMed1997

[Pulmonary infection with Mycobacterium kansasii presenting as solitary nodule shadow in the left anterior basal segment].

A 71-year-old man was admitted to our hospital for evaluation of a solitary pulmonary nodule in the left lower lung field. He had been treated for Parkinson's disease for two years, and had no respiratory symptoms on admission. No abnormal findings were detected in laboratory tests on admission, and Mantoux's skin test was negative. A postero-anterior chest roentgenogram, a conventional tomogram, and a computed tomogram showed that the nodule was located in the left anterior basal segment (S8). The nodule was not calcified, the contour was clear but irregular, and pleural indentation could be seen, so the nodule was strongly suspected to be a primary malignant lung tumor. Because two attempts at transbronchial lung biopsy and bronchial brushing and washing were of no diagnostic value, a thoracotomy was done. The lesion was found in the subpleural region of the left S8 with pleural indentation, and it was partially resected. The nodule was elastic, soft, and filled with suppurative fluid. Histopathologic examination of the nodule revealed epithelioid cell granuloma. A smear test of the fluid was negative but a culture was positive for mycobacteria; which were identified as Mycobacterium kansasii. Rifampicin and isoniazid were administrated to the patient for 1 year. Two years after the operation, the patient was asymptomatic.

Aged↗
PubMed1997

[A case of primary orbital chondrosarcoma].

The case of a twenty-year-old male with orbital chondrosarcoma is reported. He visited National Defense Medical College Hospital because of reduced vision in the right eye since two months previously. His corrected visual acuity was 8/20 in the right eye and 20/20 in the left eye. Fifteen degrees lateral displacement of the right globe and limitation of right ocular movement were recognized. Right fundus examination revealed optic disc edema and protuberant nasal fundus. Orbital computed tomography (CT) demonstrated a high density area between the inner part of the right orbit and the ethmoid sinus. Magnetic resonance imaging (MRI) showed a smoothly outlined and low intensity (T1) space occupying lesion. This lesion was irregularly enhanced by gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA). This orbital tumor was removed by an anterior approach. Histopathological examination revealed well-differentiated chondrosarcoma (grade 1) as determined by small prominent chondromatous cell projection into the collagen fibrous stroma, and existence of binucleate cells in the hypercellular region. After the operation the disc edema disappeared and his corrected right visual acuity improved to 20/20.

Adult↗
PubMed1997

[Time course of epidural pressure change under intraperitoneal insufflation during laparoscopic surgery].

The effect of intraperitoneal insufflation on epidural pressure (EPP) was studied in 10 patients undergoing laparoscopic cholecystectomy under general anesthesia. Epidural puncture was performed at T8/9 interspace. After placing an epidural catheter, EPP was recorded continuously using a pressure transducer. Ventilation was controlled to maintain PETCO2 at 30-35 mmHg. Intraperitoneal pressure was maintained at 8-12 mmHg by using CO2 gas insufflator. During EPP measurements, the patients were supine on a horizontal operating table and zero point was referred to the level of the external auditory meatus. ECG and direct BP were also monitored. Before anesthetic induction, the mean EPP was 15.5 +/- 2.0 mmHg. During the mechanical ventilation, EPP recordings showed two types of periodic waves: large and small. The large waves were observed in phase of positive pressure ventilation, and the small waves were synchronous with arterial pulsations. Intraperitoneal insufflation produced an immediate increase in EPP (19.8 +/- 4.2 mmHg after 1 min, 22.8 +/- 5.8 mmHg after 5 min). An immediate decrease in EPP to the baseline level was observed just after the release of intraperitoneal pressure. The results suggest that 1) EPP is positive and fluctuates with ventilation and arterial pulsations, 2) intraperitoneum insufflation produces an increase in EPP that lasts until the procedure is discontinued, and 3) increased intrathoracic and intraperitoneal pressures play a predominant role in producing the elevation of EPP.

Adult↗
PubMed1997

[The usefulness of 18F-FDG SPECT imaging in evaluating myocardial viability].

UNLABELLED: We compared myocardial viability evaluated by 18F-deoxyglucose (FDG) SPECT in 14 old myocardial infarction patients with that evaluated by 201TI SPECT and 123I-beta-methyl-iodophenyl pentadecanoic acid SPECT as imaging of fatty acid metabolism. FDG-SPECT was performed after oral administration of glucose. From each SPECT image which was divided into 7 segments, the degree of accumulation of each radioisotope (RI) was visually classified into four grades of defect score (ranging from 0 as normal to 3 as severe defect). The % uptake in the same area was also quantitatively calculated. RESULTS: The degree of accumulation of myocardial Rl relative to regional wall motion. FDG is the most wide for a range of accumulation of Rl of infarct area. Also, at FDG, in the area of wall motion had done a disorder, the degree of accumulation was higher than other two methods. In the infarcted area, the degree of accumulation on FDG-SPECT in the area of decreased wall motion was greater than that on the other two procedures. These results suggest that FDG-SPECT is useful for evaluating myocardial viability.

Aged↗
PubMed1997

[Treatment of age-related subfoveal choroidal neovascularization by low-dose external radiation: a preliminary study].

We applied low dose external beam radiation (6 MV) to 17 eyes of 17 patients (Mean age 70.9 years, range 58 approximately 85) who had subfoveal choroidal neovascularization associated with age-related macular degeneration. None of the cases were suitable for photocoagulation according to the Macular Photocoagulation Study protocol, and no feeding vessels underlying choroidal neovascular membrane could be detected. Corrected visual acuity ranged from 0.02 to 0.6 before treatment. The patients were divided into two groups. One group of 11 eyes was treated with 10 Gy and the other group of 6 eyes with 21 Gy. Mean follow up period was 347 +/- 89 (mean +/- standard deviation) days in the 10 Gy group and 312 +/- 100 days in the 21 Gy group. We evaluated the outcome as "effective' if no progression in neovascular membrane was found by ophthalmoscopic and angiographic examination. Only 3 eyes (21%) of patients in the 10 Gy group and 2 eyes (33%) in 21 Gy group showed any effect. Although the rate of progression in choroidal neovascular membrane was significantly smaller in the 10 and 21 Gy group than in the controls, the corrected visual acuity in the treated group was not improved over that of the controls. No serious complications were seen. Only one case showed a stabilized neovascular membrane in the control group of 7 patients. Although the present results seem to be worse than those in previous reports, the efficacy of this treatment still needs to be evaluated because no beneficial strategies in the treatment of subfoveal neovascularization have been established.

Aged↗
PubMed1997

[Compton-scatter correction using the triple energy window (TEW) method in conventional single photon emission computed tomography without TEW acquisition hardware].

We devised a method which allowed the triple energy window (TEW) method to be applied for Compton-scatter correction in conventional single photon emission computed tomography (SPECT) systems without any hardware for TEW acquisition. In this method, the data within two subwindows located at both sides of the main window were acquired together. The effectiveness of this method was investigated by phantom experiments. The integral and differential uniformities measured using a flood phantom filled with 123I were minimized when the energy width of subwindows was 5 keV (5.8% and 4.2%, respectively). When this method was applied to a brain phantom filled with 123I in which the relative activities in white and gray matter were assigned as 1: 4.3, the ratio of SPECT values between them was more accurate (1:4.26) than that obtained without this method (1:208). This method appears to be useful for Compton-scatter correction in SPECT, because it can be applied to conventional SPECT systems without any hardware for TEW acquisition and is available for routine clinical use for its simplicity.

Brain↗
PubMed1997

Lifetime treatment of mice with azidothymidine (AZT) produces myelodysplasia.

AZT has induced a macrocytic anemia in AIDS patients on long term AZT therapy. It is generally assumed that DNA elongation is stopped by the insertion of AZT into the chain in place of thymidine thus preventing the phosphate hydroxyl linkages and therefore suppresses hemopoietic progenitor cell proliferation in an early stage of differentiation. CBA/Ca male mice started on AZT 0.75 mg/ml H2O at 84 days of age and kept on it for 687 days when dosage reduced to 0.5 mg/ml H2O for a group, another group removed from AZT to see recovery, and third group remained on 0.75 mg. At 687 days mice that had been on 0.75 mg had average platelet counts of 2.5 x 10(6). Histological examination on 9 of 10 mice with such thrombocytopenia showed changes compatible with myelodysplastic syndrome (MDS). A variety of histological patterns was observed. There were two cases of hypocellular myelodysplasia, two cases of hypersegmented myelodysplastic granulocytosis, two cases of hypercellular marrow with abnormal megakaryocytes with bizarre nuclei, one case of megakaryocytic myelosis associated with a hyperplastic marrow, dysmyelopoiesis and a hypocellular marrow and two cases of myelodysplasia with dyserythropoiesis, hemosiderosis and a hypocellular marrow. Above mentioned AZT incorporation may have induced an ineffective hemopoiesis in the primitive hemopoietic progenitor cells, which is known to be seen commonly in the myelodysplastic syndrome.

Acquired Immunodeficiency Syndrome↗
PubMed1997

Radiation-induced myeloid leukemia in mice under calorie restriction.

The host-defense mechanisms against cancers are known to be modulated by changing the environmental factor(s). The spontaneous incidence of myeloid leukemia is about 1% in C3H/He mice, and the incidence increases up to 23.3% when a single dose of radiation, 3 Gy X-ray, is exposed to a whole-body. Since calorie restriction was known to reduce the incidence of spontaneous tumors, a question as to whether such radiation induced-increase of myeloid leukemia would be also decreased by calorie restriction, was aimed to answer to elucidate possible mechanism of radiation-induced myeloid leukemia. By the calorie restriction, the incidence of myeloid leukemia was significantly decreased. In addition, the latent period of the myeloid leukemia in the groups for calorie restriction was significantly extended at a greater extent as compared with the control diet groups. Number of hemopoietic stem cells, the possible target cells for radiation-induced leukemias, in the groups for the calorie restriction demonstrated a significant decrease, especially in the spleen, as compared with that in the control, when the evaluation was made at the time of radiation exposure.

Animals↗
PubMed1997

The p53-deficient hemopoietic stem cells: their resistance to radiation-apoptosis, but lasted transiently.

Hemopoietic stem cells lacking with p53 are known to be resistant to radiation apoptosis: p53-product induces, on one hand, the cells that have been injured by radiation to stop cell-cycle at G, phase, and on the other hand the cells that have not been repaired to go into apoptosis. Thus, in the p53-deficient mice, the hemopoietic stem cells after graded dose of radiation show a flatter survival curve for radiation, i.e., like a curve for radio-resistant phenotype. However, we found the radio-resistance in the stem cell was only transient, and an apoptosis in p53-deficient hemopoietic stem cells, we made concentrated analysis including the end-labeling technique to detect double strand breaks of DNA. Results clearly showed that, according to the end-labeling for spleen colonies, the p53-deficiency showed rather higher incidence of apoptosis (30-50%) as compared with the wild-control (17%). Irradiation with 200cGy for the recipient mice two months after transplantation, showed an induction of higher incidence of hemopoietic malignancies, when the heterozygous marrow was repopulated, however, none of increase was observed in the recipient mice repopulated with the homozygous bone marrow. Clear difference between the hetero- and the homozygous in inducing hemopoietic malignancies with the 200cGy-radiation may be reflected by the different degree of delayed appearance of apoptosis during the development of the spleen colonies.

Animals↗
PubMed1997

[Severe aortic regurgitation with marked thickening of the aortic annulus: a case report].

A 74-year-old woman with severe aortic regurgitation and marked thickening of the aortic annulus received aortic valve replacement. Transesophageal echocardiography demonstrated marked thickening of the aortic annulus. The maximum thickness of the aortic annulus was about 11 mm at the side of the right coronary cusp. Histological examination revealed non-specific inflammation of the aortic annulus and aortic valve chiefly composed of lymphocytes and plasma cells. Thickening of the aortic annulus associated with inflammatory aortitis was the cause of aortic regurgitation in this patient.

Aged↗
PubMed1997

[Successful surgical treatment of aortic regurgitation due to annuloaortic ectasia and mitral regurgitation caused by tendon rupture in a case of osteogenesis imperfecta].

A 54-year-old man presented with osteogenesis imperfecta complicated with both aortic regurgitation due to annuloaortic ectasia and mitral regurgitation secondary to tendon rupture. He had spinal and carpal deformities in his childhood, and heart murmurs were identified at the age of 25. He was admitted complaining of dyspnea on effort. His height was 142 cm and his weight was 46 kg. He had kyphosis, scoliosis and carpal deformity. Blue sclera was not observed. Chest radiography showed cardiomegaly and lung congestion. Echocardiography showed annuloaortic ectasia, mild aortic regurgitation, and serious mitral regurgitation due to postero-apical tendon rupture. Bone deformity and his statues were indicative of osteogenesis imperfecta. He received modified Bentall and mitral valve replacements.

Aortic Valve Insufficiency↗