[Optic nerve regeneration and functional recovery of vision following peripheral nerve transplant].
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Animals↗
Biomedical subjects
T Inoue
Publications and source records attributed to T Inoue.
QT interval prolongation in the patients receiving maintenance hemodialysis.
QT prolongation is associated with a poor prognosis in patients with various diseases. The pathogenesis of the long QT syndrome is not well understood and little is known about the QT interval in the patients receiving maintenance hemodialysis. We evaluated changes in the QTc interval and investigated factors that contribute to its prolongation in 42 patients receiving maintenance hemodialysis. We also examined the association between the QTc interval and ventricular arrhythmias on 24-h ambulatory electrocardiograms. Comparison of standard 12-lead electrocardiograms of 42 patients and of 30 healthy controls matched for age and sex showed that the QTc interval in the patients was significantly prolonged (432.6 +/- 24.9 vs 402.0 +/- 21.0 ms, p <0.001). Multivariate analysis using stepwise multiple regression identified diabetes mellitus and the ejection fraction measured by echocardiography as independent risk factors for QTc prolongation. The QTc interval was significantly prolonged in patients with complex VPCs (couplets or salvos) (n = 13, 447.9 +/- 14.4 ms) on 24 h ambulatory ECG compared with simple VPCs (none or occasional) (n = 29, 425.6 +/- 25.8 ms) (p = 0.03). In conclusion, the QTc interval was prolonged in patients receiving maintenance hemodialysis and QTc prolongation was associated with complex VPCs. Decreased myocardial contractility and diabetes mellitus contributed to QTc prolongation.
Arrhythmias, Cardiac↗
[p53 and Bax protein expression as predictor of chemotherapeutic effect in gastric carcinoma].
This study was performed to estimate p53 and Bax overexpression as a predictor of the response to chemotherapy of patients with gastric cancer. The subjects were 20 patients with stage IV gastric cancer and 3 with locally recurrent lesions treated with 5-fluorouracil (5-FU) and low-dose cisplatin (CDDP) for 4 weeks. Of the total 23 patients, there were 10 responders: 2 showing complete response (CR) and 8, partial response (PR). Carcinoma biopsy specimens of all were obtained endoscopically with anti-p53 and anti-Bax antibodies. Of the 10 responders, 7 were in the negative p53 staining group, while of the 13 non-responders, 11 were in the positive p53 staining group (p = 0.013). But no correlation was demonstrated between the chemotherapeutic effect and Bax staining alone. Moreover, among the p-53-positive cases, the patients with Bax-negative tumors were all chemoresistant. Therefore, immunohistochemical identification of p-53 and Bax prior to chemotherapy may be a useful predictor for choice of non-responders to chemotherapy.
Adenocarcinoma↗
Detection of platelets activated during acetylcholine-induced coronary vasospasm.
Although platelet activation may play a role in coronary artery spasm, platelets activated following coronary vasospasm have not been clinically detected. We performed flow cytometric analysis of activation-dependent granular proteins, CD62P (P-selectin), CD63, PAC-1 (activated glycoprotein [GP] IIb/IIIa) and thrombospondin on the platelet plasma membrane in patients who exhibited acetylcholine-induced coronary vasospasm and compared findings with those in control patients without vasospasm. We simultaneously investigated the plasma levels of thrombin anti-thrombin III complex (TAT), plasmin alpha2-plasmin inhibitor complex (PIC), and thrombomodulin. In patients with vasospasm, the expression of CD62P, CD63 and PAC-1 on the platelet membrane surface increased in coronary sinus blood samples following coronary vasospasm, although the expression in aortic samples did not change. The TAT level also increased in the coronary sinus after vasospasm. Platelets might be activated by coronary vasospasm within the coronary circulation. The platelet activation process may be modulated by thrombin generation.
Acetylcholine↗
[A case of pulmonary tuberculosis complicated with intracranial tuberculous abscess].
A 75-year-old male was admitted to our hospital with complaints of fever and cough. Chest X-ray showed infiltrative shadows with cavity, and sputum smears were positive for acid-fast bacilli. About 2 months after the initiation of anti-tuberculous chemotherapy, suddenly generalized convulsion occurred. CT of the brain showed the solitary mass with the ring enhancement in the left subcortical area. About 4 weeks later, brain aspiration drainage was performed and pus was aspirated. He was diagnosed as intracranial tuberculous abscess. After the drainage, neurological symptoms disappeared completely and there were no recurrence of abscess. Attention should be called to the complication of intracranial tuberculosis, especially in cases worsened during anti-tuberculous chemotherapy.
Aged↗
[Intravesical bacillus Calmette-Guerin instillation for patients over 80 years old].
To study the efficacy and the safety of intravesical bacillus Calmette-Guerin (BCG) therapy for very elderly patients with superficial bladder cancer, we retrospectively compared patients over 80 years old who had received BCG therapy at our department between 1991 and 1996 (Group A; 10 patients 11 courses), with those below 80 years old (Group B, 17 patients 18 courses). In these patients, skin test reactivity to purified protein derivative showed a significant negative correlation with age (p = 0.016). No irreversible complications were observed in any patient. Persistence of acid-fast bacilli for more than one month after the termination of the course was observed in two patients in group A, and one in group B. A comparison of the cases undergoing eradicational BCG therapy in the two groups, grade 2 transitional cell carcinoma (TCC) was significantly more predominant than grade 3 TCC in group A (p = 0.004). (None of the tumors in group A were of grade 3) The disease-free rate was significantly lower in group A (p < 0.05), but 5 of the 10 patients in this group were finally disease-free. From these results, we conclude that intravesical BCG instillation therapy can be performed in patients over 80 years old, although a relatively lower disease-free rate is expected and special attention should be taken with regard to persistent BCG infection. The lower disease-free rate could be attributable to either diminished cellular immunity or a difference in tumor grade, although a definite conclusion could not be obtained here.
Administration, Intravesical↗
Trigeminal neuralgia caused by the metastasis of malignant lymphoma to the trigeminal nerve: a case report.
The authors cared for a patient suffering from left trigeminal neuralgia who had systemic malignant lymphoma which had been treated with chemotherapy. The lesion of the left trigeminal nerve was not detected by brain CT scans or by the magnetic resonance images made at the onset of trigeminal neuralgia. However, metastasis to the left trigeminal nerve root was disclosed 6 months after the onset of the systemic lymphoma. Open biopsy confirmed lymphomatous involvement of the left trigeminal nerve root. In this case the site of the metastasis was mainly the trigeminal nerve root entry zone in the cerebellopontine cistern, and the lesion caused left trigeminal neuralgia and sensory impairment.
Aged↗
[Risk factors in aged patients undergoing gastrointestinal cancer operations].
With the rapid increase in the elderly population in Japan and the continued advances in perioperative management and operative techniques, more surgical procedures will be performed in the geriatric patients. The loss of reserve capacity and associated disease in the elderly patients may lead to an inappropriate response to surgical stress, resulting in high morbidity and mortality. Therefore, the identification of surgical risk is imperative in the surgical care of aged patients. The risk factors in the aged include malnutrition, anemia, cerebrovascular disease, hepatic disorders and immunosuppressive therapy. This review focuses on the risk factors and simple method to estimate the surgical risk in aged patients undergoing gastrointestinal cancer surgery.
Aged↗
[A case of hepatocellular carcinoma with reduction of primary tumor and disappearance of multiple lung metastasis].
A 56-year-old male had suffered from hepatocellular carcinoma treated by operation, PHoT and TAE since 1994. In December 1995, he had multiple metastases of lung in addition to recurrence of primary hepatic lesions. We discontinued treatment of TAE and decided to administer UFT (400 mg/day) orally as an outpatient. After seven months, the primary hepatic lesions were decreased in size, and metastatic lesions of lung were completely eliminated with reduction of AFP level. Generally, hepatocellular carcinoma with metastasis is refractory to treatment. However, this result suggests that UFT is one of the effective treatments for such advanced cases as having lung metastasis.
Administration, Oral↗
[Application of new technology to toxicology: dynamic analysis of hematopoietic stem cells-BUUV method].
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Animals↗
[Ultrasound bone densitometry of os calsis].
In the last couple of years, Ultrasound bone densitometry (QUS: Quantitative ultrasound) have been developed which allow the assessment of fracture risk caused by osteoporosis. QUS are particularly promising since they are simple, inexpensive, portable, non-invasive and they do not subject the patient to any ionising radiation. Additional investigations that assess innovative QUS techniques in well defined research settings are important to determine and utilize the full potential of this technology for the benefit of early detection and monitoring of osteoporosis.
Adult↗
[Histopathological findings and clinical effects for acute rejections].
We reviewed 115 cases of acute rejection following renal transplantation. All cases were diagnosed after graft biopsy, and showed histopathological evidence of acute rejection. They were treated with administration of OKT3, 15-deoxyspergualin (DSG), anti-lymphocyte globulin (ALG) or methylprednisolone (MP). All rejections were histopathologically classified according to the Banff working classification. The clinical effects of each drug were evaluated both at 1 month and 1 year following the therapy for rejection, by measurement of serum creatinine level. The effective rate both at 1 month and 1 year was related with the Banff working classification ( p < 0.0001). At 1 month after treatment, there were no significant differences between the OKT3, DSG or ALG group and MP group in cases of borderline change and AR grade I. In cases of grade II and grade III, a significant difference was observed between the OKT3 or ALG group and MP group (p < 0.05). The DSG group showed a slightly better outcome than the MP group, although the difference was not significant. In conclusion, the Banff schema is shown to be valid for classification of acute renal allograft rejection, and it is necessary to determine the treatment for acute rejection according to histopathological classification.
Acute Disease↗
[Diffusion-weighted MRI detectability of acute cerebral ischemia: comparison with eventual infarction].
To clarify the clinical significance of diffusion-weighted magnetic resonance imaging (DWI) hyperintensity in acute cerebral ischemia, 34 patients were investigated with cerebral ischemia that had lasted no more than 8 hours. Either a spin echo sequence with navigator echo (n = 21) or an echo planar sequence (n = 13) was used for DWI using 1.5 tesla magnet. The eventual infarction was judged from T2-weighted image (T2 WI) or CT performed 2-12 days after the onset and was classified into cortical (n = 24) or perforating artery (n = 10) area. The eventual infarction was compared in size with the acute DWI finding and expressed as larger, same or smaller. Thirty patients showed ischemic hyperintensity lesions on acute DWI (6 patients on T2 WI). In cortical artery areas, the eventual infarction was same as hyperintensity area of acute DWI in 15 cases, larger in 8 cases, smaller in 2 cases. In perforating artery areas, the eventual infarction was same as hyperintensity area of acute DWI in 8 cases, and larger in 2 cases. These results suggest that in the perforating artery areas, the acute DWI hyperintensity is a good predictor of the eventual infarction and that in cortical artery areas, dynamic ischemic process may continue for hours before resulting in the eventual infarction.
Acute Disease↗
Acute effects of fracture on bone markers and vitamin K.
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Aged↗
[Aortic and mitral valve aneurysms complicated with infective endocarditis: a case report].
A rare case of aortic and mitral valve aneurysms complicated with infective endocarditis was accurately diagnosed by transesophageal echocardiography. A 57-year-old man with severe aortic regurgitation due to infective endocarditis was admitted to our hospital. Transthoracic echocardiography showed an aortic valve aneurysm on the right coronary cusp and perforations on the other cusps. Transesophageal echocardiography demonstrated a small aneurysm on the anterior leaflet of the mitral valve which was not clearly visualized by transthoracic echocardiography. Color Doppler echocardiography revealed severe aortic regurgitation and mild mitral regurgitation without perforation of the mitral valve aneurysm. Aortic valve replacement and mitral valvuloplasty of the anterior mitral leaflet were performed. The right coronary cusp of the aortic valve showed marked thinning with infiltration of inflammatory cells. The postoperative clinical course was uneventful.
Aortic Valve↗
Suppressive effects of the new antirheumatic drug KE-298 on TNF alpha-induced production of matrix metalloproteinases but not of tissue inhibitor-1 of metalloproteinases in human rheumatoid synoviocytes.
KE-298 is a novel antirheumatic drug which suppresses various animal models of arthritis by inhibiting the production of inflammatory cytokines. In a phase II study of rheumatoid arthritis patients, ingestion of KE-298 led to significant improvements in the Lansbury index. The objective of the present study was to clarify the effects of KE-298 against synovium functions, using rheumatoid arthritis synoviocytes. We investigated the effects of KE-298 on the production of matrix metalloproteinases and tissue inhibitor-1 of metalloproteinases and bone absorptive mediators including interleukin (IL)-6 and prostaglandin (PG) E2 in tumor necrosis factor (TNF)-alpha-stimulated rheumatoid arthritis synoviocytes. Rheumatoid arthritis synoviocytes were obtained from knee joints of rheumatoid arthritis patients and type B fibroblast-like synoviocytes were stimulated with TNF-alpha, with or without KE-298. The contents of metalloproteinases and tissue inhibitor-1 of metalloproteinases and IL-6 and PGE2 in culture media were measured by enzyme-linked immunosorbent assay. KE-298 significantly suppressed TNF-alpha-induced production of promatrix metalloproteinase-1 and IL-6, in a dose-dependent manner, but not that of tissue inhibitor-1 of metalloproteinases. The potential of KE-298 to suppress the production of matrix metalloproteinase-1 and IL-6 may explain its efficacy on rheumatoid arthritis.
Antirheumatic Agents↗
Tyrosinemia type I-like disease: a possible manifestation of 3-oxo-delta 4-steroid 5 beta-reductase deficiency.
BACKGROUND: It has been suggested that quantitative analysis of urinary bile acids may help to distinguish primary 3-oxo-delta 4-steroid 5 beta-reductase deficiency from the excretion of 3-oxo-delta 4 bile acids that occurs as a result of liver damage. METHODS: Urinary bile acids were quantitatively analyzed by gas chromatography-mass spectrometry in four Japanese patients with severe neonatal cholestasis associated with hypertyrosinemia without urinary succinylacetone (i.e. tyrosinemia type I-like disease). These four patients represented sporadic cases. RESULTS: Large amounts of 3-oxo-delta 4 bile acids were detected, which comprised greater than 80% of the total urinary bile acids. Small amounts of allo-bile acids and primary bile acids were also detected, comprising less than 1% and 15% of the total urinary bile acids, respectively. CONCLUSIONS: It was suspected that these four patients had a primary 3-oxo-delta 4-steroid 5 beta-reductase deficiency. However, it is possible that some patients in this study may have had a secondary 3-oxo-delta 4-steroid 5 beta-reductase deficiency, caused by idiopathic neonatal cholestatic liver failure.
Amino Acid Metabolism, Inborn Errors↗
[Investigation on feasibility of using a gamma camera for the measurement of blood radioactivity].
The present study was undertaken to determine whether gamma cameras can be used to measure radioactivity in samples, e.g. in blood. Aqueous 123I solution with a concentration of 10.3 MBq/ml was infused at a volume of one ml into a blood-sampling vial having an internal diameter of 22.5 mm. Various concentrations of radioactivity were generated by leaving the vial and taking radioactive decay into account. Static images were acquired for five minutes with a gamma camera using a 64 x 64 matrix to measure radioactivity counts, and the regions of interest with 7 x 7 pixels (21 mm x 21 mm) were defined on the image. The results showed that there was a good linear correlation between the radioactivity counts measured with the gamma camera without collimator and those measured with the well-type scintillation counter in the range between 0.032 kBq/ml and 279 kBq/ml. It therefore appears that gamma cameras can be substituted for well-type scintillation counters in the measurement of radioactivities in samples.
Blood↗