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Biomedical subjects

T Inou

Publications and source records attributed to T Inou.

At least 73 records · Page 4Linked to original sources
PubMed1978

Screening of anti-B cell antibodies in the sera of renal transplant recipients by using Daudi cell line.

In order to examine the presence of antibodies against B cells, 83 sera obtained from 55 renal transplant recipients were screened by microcytotoxicity test using Daudi cell line. Out of 83 samples, 12 were pretransplant sera, 62 were post-transplant sera and 9 were from the patients whose grafts has been removed due to rejection. For the purpose of improving the reliability of the tests, 5 different rabbit complements were selected and cytotoxicity tests with them were carried out simultaneously. Pretransplant sera without blood transfusion did not show any cytotoxicity against Daudi cells. Although 42% of post-transplant sera showed cytotoxicity against Daudi cells, cytotoxic activity of the sera showed no relation with the occurrence of rejection episodes. Three serum samples out of 5 patients whose grafts had been removed due to rejection showed strong cytotoxicity against Daudi cells and the sera of 2 other patients did not. There was no relation between the cytotoxicity against Daudi cells and antibodies against Epstein-Barr virus capsid antigen in the post-transplant sera.

Animals↗
PubMed1978

Chorio-meningo-encephalitis due to Listeria monocytogenes after renal transplantation.

A 35-year-old man, who underwent renal transplantation, died of meningo-encephalitis with symptoms of meningitis for only 8 days. The autopsy revealed marked chorio-meningo-encephalitis caused by Listeria monocytogenes. This report on listeriosis in renal transplant patients is the second in our country, where adult cases of listeriosis are rare. Recent knowledge about listeriosis in renal transplants is reviewed and discussed.

Adult↗
PubMed1978

Heterophile antibodies in the sera from renal transplant recipients.

Microcytotoxicity tests with the sera from renal transplant recipients against cultured B-cell lines were performed by using guinea pig complement. Out of 106 sera, 18 sera showed strong cytotoxicity against cultured cell lines. The same results were obtained by using normal human serum as a complement source. These sera did not show any cytotoxicity against normal peripheral T- and B-lymphocytes. On the other hand, the sera containing the cytotoxicity against cultured B-cell lines were found to have high-titered heterophile antibodies against bovine red blood cells (BRBC) when hemolysis in agar gel with guinea pig complement was used. The sera without cytotoxicity did not have high-titered heterophile antibodies. The sera with cytotoxicity against cultured B-cell lines reacted in the same way against both human tonsilar lymphocytes cultured with the medium containing fetal calf serum and human serum. Therefore, the antigenicity of cultured cells was not affected by the fetal calf serum in the culture medium. After absorption with BRBC, the sera lost their cytotoxicity against cultured cells. Hemolysins in the sera were almost completely removed after absorption of the sera with cultured cells. From these results, it seemed apparent that the sera from renal transplant recipients contained heterophile antibodies which reacted with the cells of some cultured B-cell lines and tonsilar lymphocytes.

Animals↗
PubMed1977

Effects of the combination of tumor-specific and nonspecific immunization on tumor suppression.

The crushed whole Aoyama B cells attached to oil droplets were found to be most suitable for the adjuvant effect of Mycobacterium tuberculosis against tumor growth when judged by the criterion of effectiveness and a clinical application with minimal side effects. The immunogenicity of tumor cells was well stabilized and maintained with a suitable concentration of formalin; this was less than 1% and the optimum concentration was 0.05% or 0.1%. When the tumor cells treated with the optimum concentration of formalin were combined with suitable adjuvant, immunoprotection against the tumor progress was accelerated.

Adjuvants, Immunologic↗
PubMed1977

[Crush syndrome].

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Acute Kidney Injury↗
PubMed1976

Immunologic and chemical studies on mucopolysaccharide derived from murine lymphosarcoma.

Mucopolysaccharide was prepared from media in which the Gardner's lymphosarcoma cells were cultured. Multiple intraperitoneal injections of the preparation into syngeneic mice resulted in enhancement of the tumors which were inoculated prior to the injections. Sera of these hosts contained antibodies reacting with antigens of the outer layer of the tumor cells. Chemical analyses of the preparation showed that the mucopolysaccharide is composed of hexosamine, uronic, acid, hexose, and proteins. The mucopolysaccharide was shown to possess unique migration rate on electrophoresis and thin layer chromatography.

Animals↗
PubMed1976

Properties of hepatic tissue extracts: 2. An approach to the artificial liver.

In the previous paper [3], the lethal effect of normal rabbit liver extract intravenously infused into rabbits was described. By comparing to the course of destruction of the liver tissue in fulminant hepatitis, the toxicity of the liver extract was recently studied. Attempts were also made to adsorbing the liver extract by activated clay and detoxifying the liver extract with a formaldehyde solution, and the results suggested that the findings would be applicable as an approach to the artificial liver.

Adsorption↗
PubMed1976

HLA antigens in Japanese populations.

HLA antigens in 841 healthy, unrelated Japanese from nine widely separated geographic localities were studied. The five most common antigens observed in order of decreasing frequency were for the HLA-A locus: HLA-A9, A2, A10, AW32 and A11; and for the HLA-B locus: HLA-'B5' (= HLA-B5+B17), BW40, B12, B14 and B8. The allelic frequency of undetected antigens of the HLA-A locus was .14-.37, and that of the HLA-B locus, .32-.67, indicating that there were serological difficulties in typing for Japanese antigens using antisera from Caucasians. Marked gene frequency clines were observed for HLA-A9 and HLA-A2 from south (Okinawa) to north (Nagoya). Two haplotypes, HLA-A9, B5 and HLA-A10, BW40 were shown to be in linkage disequilibrium in four of the nine subpopulations.

Alleles↗
PubMed1975

Inhibitory effect of progesterone on the phytohaemagglutinin- induced transformation of human peripheral lymphocytes.

Effect of sex steroids, progesterone and estradiol-17beta, on transformation of human lymphocytes induced by PHA was investigated. Responses of peripheral lymphocytes from non-pregnant women to PHA was markedly reduced in the presence of progesterone at a concentration of 10(3) or 10(4) ng/ml. Estradiol-17beta, on the other hand, had no effects on the PHA-induced transformation under the present experimental conditions. The immunosuppressive property of progesterone may contribute to depression of maternal cell-mediated immunity against fetus during pregnancy.

Drug Interactions↗