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Biomedical subjects

T Inoshita

Publications and source records attributed to T Inoshita.

18 recordsLinked to original sources
PubMed1998

Hepatosplenic gamma delta T-cell lymphoma associated with hepatitis B virus infection.

Hepatitis B virus (HBV) infection has been implicated in the development of hepatocellular and hematopoietic malignancies. We describe a patient with chronic hepatitis B who developed hepatosplenic gamma delta T-cell lymphoma. A 45-year-old woman presented with marked hepatosplenomegaly and hepatic failure during the course of chronic hepatitis B. Peripheral blood examination revealed 57% abnormal lymphoid cells which expressed the gamma delta T-cell receptor. The cytogenetic analysis of tumor cells showed an abnormal karyotype; 47, XX, -13, +2mar in all 20 metaphases examined. A clonal rearrangement of the T-cell receptor genes was demonstrated by Southern blot analysis, showing monoclonal expansion of tumor cells. A liver biopsy specimen showed fibrosis of the portal areas and sinusoidal infiltration of tumor cells. HBV infection was documented by the presence of IgG anti-HBc and anti-HBs antibodies in serum. Although HBV-DNA was not detected in tumor cells by polymerase chain reaction analysis, there is a possibility that proliferation of gamma delta T cells in response to HBV infection played a role in the pathogenesis of hepatosplenic gamma delta T-cell lymphoma.

Chronic Disease↗
PubMed1986

Rounded atelectasis shown by computerized tomography.

We have reported a rounded atelectasis in a 65-year-old man. On CT scan a pleural-based mass was associated with curved, ragged projections from the lower pole of the lesion. This phenomenon appears to be the counterpart of the so-called comet tail on regular tomography and, because of its clarity, may further facilitate the diagnosis of this entity.

Aged↗
PubMed1985

Acute lymphoblastic leukemia following myelodysplastic syndrome.

A 58-year-old man presented with anemia and neutropenia. The bone marrow examinations showed changes consistent with myelodysplastic syndrome. Twenty months later, acute lymphoblastic leukemia developed. This case appears to represent myelodysplastic (preleukemic) syndrome terminating in acute lymphoblastic leukemia.

Bone Marrow↗
PubMed1984

Malignant fibrous histiocytoma arising in previous surgical sites. Report of two cases.

Two patients who developed malignant fibrous histiocytoma in previous surgical sites are reported. One patient developed malignant fibrous histiocytoma in an amputation site, and the other patient developed it in a previous hernioplasty scar. Both patients presented with a mass, clinically interpreted as a subcutaneous abscess. The light microscopic and fine structural features of these tumors are described. A possible causal relationship between previous surgery and malignant fibrous histiocytoma is discussed in view of other reported cases arising in various conditions following chronic reparative reactions.

Adult↗
PubMed1984

Metastasis of bronchogenic carcinoma to the skin involved by melanoma.

In a 52-year-old man, a cutaneous malignant melanoma developed concurrently with an adenocarcinoma of the right lung. The latter disseminated widely, and autopsy disclosed that it had also metastasized to the dermal tissue involved with the melanoma. Because it was not a metastasis into the substance of the melanoma, it was classified as an unusual type of "collision tumor" rather than a "cancer-to-cancer" metastasis.

Carcinoma, Bronchogenic↗
PubMed1983

Esophageal metastasis from a peripheral lung carcinoma masquerading as a primary esophageal tumor.

A 65-year-old man presented with progressive dysphagia, which proved to be the first clinical manifestation of a peripheral lung carcinoma (secondary to a submucosal metastasis in the esophagus). The lung tumor, hidden by the diaphragm on chest x-ray, was not suspected until a thoracotomy was done. Although dysphagia is known to be the first manifestation of bronchogenic carcinomas, such presentation in a case of a peripheral lung carcinoma has not been well described. This case is reported with a review of the literature for cases with dysphagia secondary to a metastatic tumor in the esophagus.

Aged↗
PubMed1983

Blastomycosis presenting with prostatic involvement: report of 2 cases and review of the literature.

We report on 2 patients who presented with prostatic involvement as the first prominent clinical manifestation of systemic blastomycosis. The clinical symptoms of both patients began with dysuria and urinary retention. In 1 patient skin lesions developed 4 weeks later and the initial chest x-ray findings were positive. The other patient became aware of skin lesions concurrently with the urinary symptoms and had negative chest x-ray findings. Successful treatment consisted of amphotericin B in 1 case and ketoconazole in the other case. A review of the literature revealed 8 well documented cases of blastomycosis with the initial presenting symptom of prostatic involvement. A summary of the previously reported cases is presented and the importance of recognition of skin lesions in such patients is stressed.

Adult↗
PubMed1983

Artifactual hydropic degeneration in skin biopsy specimens immersed in saline: a light and electron microscopic study.

An artifact, consisting of hydropic degeneration of the basal cells and subepidermal bulla formation, is described in skin-punch biopsy specimens immersed in normal saline. The histologic appearance and ultrastructural features of this artifact are discussed. Proper handling of skin specimens intended for immunofluorescent studies is stressed. Similarities are noted between the histologic and ultrastructural findings of this artifact and of epidermolysis bullosa simplex and pathologic hydropic degeneration, as is seen in lupus erythematosus.

Arteriosclerosis↗
PubMed1983

Cytologically malignant squamous-cell carcinoma arising in a verrucous carcinoma of the penis.

A case of verrucous carcinoma with a focus of cytologically malignant squamous-cell carcinoma is presented. This usually occurs following radiation therapy of the verrucous carcinoma, but may rarely occur de novo, as in this case. The potential usefulness of fine-needle aspiration in detecting focal anaplasia in verrucous carcinoma is discussed. This technique may be especially useful if the lesion is to be destroyed cryosurgically.

Biopsy, Needle↗
PubMed1982

Fluorescence of melanoma cells. A useful diagnostic tool.

Fluorescence seen in unstained sections from formalin-fixed, paraffin-embedded tissue from cases of malignant melanoma was studied. Fourteen of 16 primary cutaneous melanomas and six of eight metastatic melanomas were positive for yellow-green fluorescence. Four of 15 nevocellular nevi were also positive. Various other cutaneous tumors examined were completely negative. This fluorescence, which can be easily demonstrated, may be used as a valuable ancillary diagnostic test for differentiating melanoma cells from other cutaneous tumor cells.

Diagnosis, Differential↗
PubMed1981

Imbalance of T-cell subpopulations does not result in defective helper function in chronic lymphocytic leukemia.

The T-lymphocyte subpopulations identified by the Fc receptors for IgG (TG cells) and IgM (TM cells) in 12 patients with B-cell chronic lymphocytic leukemia (CLL) were quantitated and studied for functional capabilities in an in vitro assay. The TG cells in patients were elevated in relation to age- and sex-matched normal controls (P less than 0.05) resulting in an altered TM/TG ratio of 1.8 +/- 0.76 in CLL versus 5.9 +/- 3.7 in controls (mean +/- SD, P less than 0.001). Despite this altered of B cells was found to be normal as reflected by the mean helper-suppressor score of 0.77 +/- 0.13 (+/- SEM) obtained for both patients and controls. This unimpaired capacity of the T cells from CLL patients to help normal B cells mature into immunoglobulin-secreting cells indicated that hypogammaglobulinemia and monoclonal serum immunoglobulins in these patients may be a result of either an intrinsic defect in the B lymphocytes or their replacement by a neoplastic clone rather than a defect in the immunoregulatory T cells.

Aged↗
PubMed1981

Abnormalities of T lymphocyte subsets in patients with progressive systemic sclerosis (PSS, scleroderma).

Thirty-one patients with PSS (scleroderma) were examined for evidence of abnormalities in T lymphocyte subsets. TG and TM subpopulations of peripheral blood T lymphocytes were enumerated by rosetting techniques. The helper-suppressor functions of these lymphocytes were studied in the PWM-activated in vitro assay. The absolute numbers of TG cells in patients with DS as well as those with the CREST syndrome variant of PSS were decreased in comparison with those in age-matched healthy controls (p < 0.05). The numbers of TM and T "null" cells were not significantly altered (p > 0.05). The reduction in the number of TG cells was not caused by lymphocytotoxic antibodies. The mean helper-suppressor scores for patients with PSS and DS (1.25) and those with CREST syndrome (1.36) were higher (p < 0.05) than the mean score for healthy individuals (0.80). No relationship between the immunoregulatory abnormality and the presence or titer of CICs, ANAs, hypergammaglobulinemia, or various clinical manifestations of PSS could be demonstrated in individual patients. The finding of abnormalities in T lymphocyte subpopulations and the demonstration of their altered functional expression in patients with PSS indicate that immunoregulatory mechanisms may play an important role in this connective tissue disease.

Adolescent↗