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Biomedical subjects

T Imaeda

Publications and source records attributed to T Imaeda.

At least 37 records · Page 2Linked to original sources
PubMed1995

Utility of Tc-99m GSA SPECT imaging in estimation of functional volume of liver segments in health and liver diseases.

The authors examined whether there was a difference in liver function among hepatic segments in liver cirrhosis cases, and in cases of hepatocellular carcinoma (HCC) associated with liver cirrhosis. If the average counts in the lateral segment of the left lobe were set at 1, the average counts in the right upper and lower segment of the liver were 0.75 approximately 1.02 (0.89 +/- 0.09, mean +/- SD) in normal cases, 0.38 approximately 2.24 (1.01 +/- 0.39) in liver cirrhosis cases, and 0.61 approximately 2.85 (1.15 +/- 0.58) in HCC cases. There is a significant difference between normal cases and liver cirrhosis cases or HCC cases (P < 0.001). Also, in HCC cases, if the average counts in the cancer-bearing segment of the liver were set at 1, the average counts in the noncancerous segment of the liver were 0.55 approximately 2.85 (1.23 +/- 0.58), and many average counts in the cancer-bearing segment were equal to, or lower than those in the noncancerous segment. It has been found that there were significant differences in function among hepatic segments in liver cirrhosis cases, and in HCC cases. Furthermore, the liver function in the cancer-bearing segment tended to be worse due to the existence of carcinoma compared with that in the noncancerous segment.

Adult↗
PubMed1995

Prediction of pulmonary function after resection of primary lung cancer. Utility of inhalation-perfusion SPECT imaging.

To help determine whether preoperative perfusion and inhalation SPECT imagings are useful in predicting postoperative lung function, Tc-99m MAA perfusion SPECT imaging, CT scans, and pulmonary function tests were prospectively performed in 33 patients with primary lung cancer before and after lobectomy or pneumonectomy. Tc-99m Technegas inhalation SPECT imaging was performed in 6 of 33 patients as well. The authors also studied changes in radioactivity on the operated and nonoperated sides before and after surgery, examined the lowest limit value for adaptability to the operation, and made a comparison of both perfusion and inhalation SPECT imaging. The predicted postoperative values obtained from the preoperative Tc-99m MAA SPECT images correlated more closely with the measured 6-month postoperative values than with the measured 3-month postoperative values. The highest correlation coefficient (r = 0.86) was observed between the predicted forced vital capacity (FVC) value and the measured 6-month postoperative FVC value. In many cases, there was not a great difference between the 6-month and 3-month radioactivity on the operated side obtained from Tc-99m MAA SPECT images. This appears to indicate that pulmonary blood flow on the operated side has completely recovered by 3 months after surgery. However, radioactivity in both the upper and lower lobes of the nonoperated side increased soon after surgery compared with that before the operation, and had not returned to preoperative levels 6 months after surgery. The radioactivity in the right middle lobe did not change before and after surgery.(ABSTRACT TRUNCATED AT 250 WORDS)

Female↗
PubMed1994

[Analysis of three-dimensional imaging of the right hepatic vein and right portal vein branch using 2D-TOF MR angiography: evaluation of utility of MR angiography in determining puncture course on TIPS].

2D-TOF MR angiographies were performed in seven patients of liver cirrhosis with hepatocellular carcinoma to investigate three-dimensional anatomical relationships of the right hepatic vein and first order of right portal vein branch. The puncture course was set up in three-dimensional rectangular coordinates, and the bend angle and turning angle of the modified Ross needle, and puncture distance were calculated of the data measured on the A-P and L-R projection images of MR angiograms. The utility and limitation of 2 D-TOF MR angiography to determine the puncture course on TIPS were discussed in this study.

Adult↗
PubMed1994

Kinematics of the normal trapeziometacarpal joint.

Motion of the trapeziometacarpal joint was studied in 12 hands from fresh human cadavera. By use of a magnetic tracking system, a full range of motion of the first metacarpal was analyzed with respect to a defined trapezial coordinate system. The traces of the reference points on the head and base of the first metacarpal were monitored, and the instantaneous centers of rotation were calculated. During circumduction, the reference points on the head and base followed elliptical paths but in opposite directions. The average instantaneous center of circumduction was at approximately the center of the trapezial joint surface. In flexion-extension, the axis of rotation was located within the trapezium, and the path of the head was identical to the path of the base. In abduction-adduction, the axis of rotation was located distal to the trapezium within the base of the first metacarpal, and the base and head moved in opposite directions. There was no single center of rotation; rather, instantaneous motion occurred reciprocally between these centers of rotation within the trapezium and metacarpal base in the normal thumb. This changing instantaneous center of rotation results in a unique pattern of motion which is related to congruent, tightly constrained joint surfaces of two reciprocal saddle joints and to precisely positioned extraarticular ligaments.

Humans↗
PubMed1994

Kinematics of the trapeziometacarpal joint after sectioning of ligaments.

This study was designed to examine the roles of ligaments in the maintenance of the articular kinematics of the trapeziometacarpal joint. Circumduction of the trapeziometacarpal joint was studied in 12 hands from fresh human cadavera. With use of a magnetic tracking system, changes in the motion of the base of the first metacarpal after ligament sectioning were analyzed and compared with those of the normal joint. Two sets of ligaments were sectioned: (a) the anterior oblique and ulnar collateral ligaments and (b) the first intermetacarpal ligament and the ulnar joint capsule. Sectioning of the anterior oblique and ulnar collateral ligaments resulted in a significant dorsal-ulnar shift in the path of the base of the first metacarpal. However, sectioning of the first intermetacarpal ligament did not affect the movement pattern of the center of the base. The anterior oblique and ulnar collateral ligaments provided constraint of the trapeziometacarpal joint during circumduction of the thumb.

Humans↗
PubMed1994

Lateral stability of proximal interphalangeal joint replacement.

The lateral stability of the cadaver proximal interphalangeal joint was studied with an electromagnetic tracking system before and after implant replacement. Ten middle fingers were retrieved and randomly divided into two groups for joint replacement with either a silicone rubber flexible finger joint implant or a custom surface replacement prosthesis. Each finger was mounted on a fixture that allowed loading of the proximal interphalangeal joint with tension through the flexor, extensor, and intrinsic tendons. For the intact proximal interphalangeal joint under lateral stress, lateral angulation averaged 4 degrees in extension and 8 degrees with the joint in 60 degrees of flexion. Although lateral angulation increased after surface replacement prosthesis implantation when the joint was flexed more than 20 degrees, comparison with the intact joint showed no statistical difference. With the silicone implant, lateral angulation became more pronounced even in the extended position and showed a significant difference when the proximal interphalangeal joint was flexed more than 20 degrees.

Cadaver↗
PubMed1994

Molecular cloning of a fungal cDNA encoding protein disulfide isomerase.

Based on the partial amino acid sequences of a protein disulfide isomerase (PDI) from Humicola insolens, two primers were synthesized for reverse transcriptase mediated polymerase chain reaction (RT-PCR) of a fungal RNA. A 0.2-kbp fragment around the consensus sequence of PDIs was obtained and used as a probe for screening a fungal cDNA library. A cDNA clone of PDI from H. insolens was isolated and encoded a polypeptide consisting of 505 amino acids, which was characterized by a N-terminal signal sequence composed of 20 amino acids, a consensus sequence (WCGHCK) at two positions, and a C-terminal endoplasmic reticulum retention signal (HDEL). Bacillus brevis harboring an expression plasmid bearing the fungal PDI cDNA was prepared and its culture supernatant showed a significant PDI activity. This indicates that glycosylation of a fungal PDI is not essential for the enzymatic activity related to an interchange of disulfide bonds.

Amino Acid Sequence↗
PubMed1993

[Superselective bronchial arterial infusion therapy with cisplatin and epirubicin hydrochloride, mitomycin C-iohexol-Lipiodol emulsion (EMILE) for hilar lung adenocarcinoma: preliminary clinical experience].

A case of hilar lung adenocarcinoma was treated by superselective bronchial arterial infusion therapy with cisplatin and epirubicin hydrochloride, mitomycin C-iohexol-Lipiodol emulsion (EMILE) using Tracker -18 infusion catheter. The tumor size was reduced on follow-up CT scans. However, EMILE was also distributed to nontumorous lung tissues around the tumor, and a shrinkage of the right upper lobe and elevations of the right hilus and diaphragm followed. No major complaints and clinical complications during and after the treatment occurred. This therapy was safe and effective for local tumor reduction in a case of hilar lung adenocarcinoma.

Adenocarcinoma↗
PubMed1993

Lung perfusion SPECT in predicting postoperative pulmonary function in lung cancer.

The aim of this prospective study is to evaluate the availability of preoperative perfusion SPECT in predicting postoperative pulmonary function following resection. Twenty-three patients with lung cancer who were candidates for lobectomy were investigated preoperatively with spirometry, x-ray computed tomography and 99mTc macroaggregated albumin SPECT. Their postoperative pulmonary functions were predicted with these examinations. The forced vital capacity and the forced expiratory volume in one second were selected as parameters for overall pulmonary function. The postoperative pulmonary function was predicted by the following formula: Predicted postoperative value = observed preoperative value x percent perfusion of the lung not to be resected. The patients were reinvestigated with spirometry at 3 months and 6 months after lobectomy, and the values obtained were statistically compared with the predicted values. Close relationships were found between predicted and observed forced vital capacity (r = 0.87, p < 0.001), and predicted and observed forced expiratory volume in one second (r = 0.90, p < 0.001). The accurate prediction pulmonary function after lobectomy could be achieved by means of lung perfusion SPECT.

Adenocarcinoma↗
PubMed1993

Anatomy of trapeziometacarpal ligaments.

The stabilizing ligaments of the thumb trapeziometacarpal joint were identified and studied during anatomic dissections of 30 hand specimens. Five main ligamentous structures were identified: (1) the anterior oblique ligament, (2) the ulnar collateral ligament, (3) the first intermetacarpal ligament, (4) the posterior oblique ligament, and (5) the dorsoradial ligament. It was observed that the anterior oblique ligament is the primary stabilizer of the trapeziometacarpal joint and is taut in abduction, extension, and pronation. The first intermetacarpal, ulnar collateral, and posterior oblique ligaments appear to be secondary stabilizers. In every specimen, the first intermetacarpal, ulnar collateral, and posterior oblique ligaments merged to form a force nucleus at the base of the first metacarpal. The dorsoradial ligament did not play a primary or secondary role in thumb stability. The clinical correlation of this anatomic study suggests that, at the minimum, the reconstruction of a primary thumb trapeziometacarpal ligament (anterior oblique ligament) is essential in the treatment of degenerative arthritis to maintain thumb stability.

Aged↗
PubMed1993

[The utility of three-phase bone scintigraphy in the assessment of fractured carpal scaphoid].

Thirty-seven joints in 36 patients with a fractured carpal scaphoid were evaluated by three-phase bone scintigraphy. They were classified into two groups according to their progress. Some were in good clinical condition and some in a non-union condition. Increased blood flow in the radial arteries and ample perfusion on and around the scaphoid bones on blood flow images suggested a good clinical course. The activity and the effectiveness of remodeling correlated well with the degree of scaphoid uptake on blood pool images taken more than seven days after the injury. Scaphoid uptake was more localized or there was almost none on blood pool images in cases with nearly complete recovery while it was amply visualized on static images. Blood pool images were indispensable for analyzing lesions and evaluating the clinical course. Two typical findings of scaphoid fractures were found on both blood pool and static images. One was diffusely increased scaphoid uptake seen in cases with a good clinical course, and the other was decreased uptake at proximal fragments seen in cases with non-union. It is concluded that three-phase bone scintigraphy provides useful information for evaluating the process of scaphoid fractures which cannot be obtained by means of conventional bone scintigraphy.

Adolescent↗
PubMed1992

Accessory bile duct draining into the stomach: case report and review.

Accessory bile duct with ectopic drainage into the gastrointestinal tract is an extremely rare congenital anomaly, and only 55 cases have been reported in the literature. We present another case of accessory bile duct draining into the stomach. Barium meal study of the stomach first revealed the accessory bile duct, and the diagnosis was confirmed by gastrofiberscopy, ultrasonography, hepatobiliary scintigraphy, computed tomography (CT), and endoscopic retrograde cholangiopancreatography (ERCP).

Adult↗
PubMed1992

Hepatocellular carcinoma with extrahepatic primary neoplasms.

We experienced seven cases of hepatocellular carcinoma (HCC) with extrahepatic primary malignant neoplasms (PMNs), which accounted for 7.5% of 93 HCC cases in our department during a 5.5-year investigation period. No common characteristics of the seven patients with extrahepatic PMNs in terms of age, sex, computed tomographic (CT) features of hepatocellular carcinoma, or presence of liver cirrhosis were evident. One of the seven cases had triple PMNs. Extrahepatic PMNs were found in various organs: stomach, colon, kidney, lung, larynx, and esophagus. Attention to extrahepatic organs should be undertaken in the management of HCC. Two patients in hepatic coma died 4 and 6 months after the diagnosis of HCC due to the advanced HCC, and accompanying extrahepatic malignancies were not the primary cause of death.

Adult↗
PubMed1992

Magnetic resonance imaging in Kienböck's disease.

With a 1.5 tesla superconducting M.R. imager and surface coil, M.R. imaging achieved high resolution analysis of the wrist on five normal wrists and 26 wrists with Kienböck's disease. The purpose of this study was to establish new criteria for diagnosis, staging and prognosis of Kienböck's disease, based on signal characteristics on T1- and T2-weighted images. Focal loss of signal intensity of the lunate on T1-weighted image was an indication of Kienböck's disease. A decreased signal containing a high spot and increased signal intensity of the lunate on T2-weighted images indicated a better prognosis. After osteotomy of the radius, the signal intensity of the lunate returned to normal and Lichtman's stage II cases had better results than those in stage III. M.R. imaging is ideal for evaluating the lunate in Kienböck's disease.

Adult↗