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Biomedical subjects

T Ikenaga

Publications and source records attributed to T Ikenaga.

36 records · Page 2Linked to original sources
PubMed1980

Colonoscopic polypectomy in diagnosis and treatment of early carcinoma of the large intestine.

Histologic investigation and analysis of 370 polyps, removed via colonoscope, demonstrated a malignancy rate of adenomas of about 20 per cent. Even small adenomas under 1 cm in diameter were found to have a higher malignant potential than previously appreciated. The malignancy rate was higher with increasing size, and adenomas in females had a much higher malignant potential than in males. It is obvious that colonoscopic polypectomy is valuable in detecting and treating early carcinomas of the colon.

Adenoma↗
PubMed1979

Changes in serum isoamylase activities after fibergastroduodenoscopy and colonoscopy. Isoamylase after FGDS and FCS.

The effects of endoscopic examination on the changes in serum amylase activity were investigated in hospitalized patients without salivary and pancreatic disorders. Sixty-nine patients were selected for the peroral fibergastroduodenal endoscopy and twenty-three patients for the peranal fibercolonoscopy. Blood samples were drawn before, immediately after, 4 hrs and 24 hrs after the termination of the examinations. The serum activities of the salivary type isoamylase increased in 7 out of 69 cases 4 hrs after the examination with the fibergastroduodenoscope, but none in all 23 cases after the examination with the fibercolonoscope. On the other hand, the serum activity of the pancreatic type isoamylase did not change following both examinations. A significant rise in serum cortisol levels was induced by both examinations. There were no correlations between the rise in salivary type isoamylase and that in serum cortisol levels. These results did not suggest that the increase of salivary type isoamylase was mediated by the hypophysio-adrenocortical axis. Other possible mechanisms were discussed.

Colon↗
PubMed1978

Nasal absorption of insulin in dogs.

The intranasal application of an insulin solution in dogs resulted in the rise of plasma immunoreactive insulin and in dose-dependent hypoglycemia. The absorption of insulin from this site was found to be enhanced when insulin was dissolved in an acid medium. In addition, when an insulin preparation with some surfactant was used, the effectiveness of nasally administered insulin was 25 to 30 per cent of that achieved with intravenously administered insulin.

Absorption↗
PubMed1978

Effect of propranolol on regional myocardial function in anesthetized open-chest dogs with myocardial ischemia.

Effects of propranolol on ischemic segmental function were studied in anesthetized open-chest dogs. Two segment-length gauges were used for measuring the regional myocardial function: one was sutured on to the left ventricular surface perfused by the anterior descending coronary artery (ischemic zone) and the other was on to that perfused by the circumflex coronary artery (normal zone). A bolus of propranolol (0.5 mg/kg) was injected into the right femoral vein. Five min later, the left anterior descending coronary artery (LAD) was completely occluded for one mine and thereafter released. Then a second coronary occlusion for 20 min was performed; an interval of 20 min was allowed between two occlusions. Propranolol, in the ischemic segment, apparently decreased the extent of paradoxical lengthening in the late systole following one min LAD occlusion, and facilitated improvement of segmental function after release of the occlusion. Moreover, the extent of abnormal stretching induced by 20 min occlusion during early systole, was also reduced by propranolol pretreatment. In contrast, compensatory increase in shortening by the normal segment was disturbed by propranolol. These results suggest that propranolol might exert a favourable influence on the segmental myocardial function during either transient or maintained myocardial ischemia.

Animals↗
PubMed1978

A patient with repeated syncopal attacks after using isosorbide dinitrate.

The case of a patient with repeated attacks of collapse induced by sublingual isosorbide dinitrate is reported. The patient was an 81 year-old female who was admitted to Yura Hospital because of attacks of precordial pain. Several minutes after the sublingual administration of isosorbide dinitrate (10 mg) for an anginal attack, she developed a sensation of general weakness, and thereafter because unconscious. Arterial blood pressure fell and became unmeasurable. Electrocardiograms recorded during the syncopal attack showed sinus tachycardia and significant elevation of ST-segment in right precordial leads. In response to a drip infusion of noradrenaline, arterial blood pressure returned to normal with recovery of consciousness. Two similar syncopal attacks induced by sublingual isosorbide dinitrate occurred in the next three days. These attacks were not due to augmentation of the vagal reflex. Decrease of venous return probably was the primary etiological factor.

Aged↗
PubMedDate not supplied

Primary hypertrophic pyloric stenosis in the adult.

A case is reported of a 55 year old male patient with primary hypertrophic pyloric stenosis who was subjected to distal gastrectomy. Adult hypertrophic pyloric stenosis is an uncommon condition which is usually misdiagnosed as carcinoma of the antrum. It is a benign disease resulting from hypertrophy of the circular fibres of the pyloric canal and is recognizable radiologically by narrowing and elongation of the pyloric canal and endoscopically by appearances resembling those of the cervix. This condition is probably congenital although aetiology has not been established. In the absence of symptoms, no clinical treatment is required. However, surgical intervention is advocated, when stenosis gives rise to symptoms, there is a suspicion of malignancy, or the ulceration due to the disease. Distal gastrectomy with gastroduodenostomy is the treatment of choice.

Diagnostic Errors↗