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Biomedical subjects

T Ida

Publications and source records attributed to T Ida.

At least 163 records · Page 9Linked to original sources
PubMed1977

Inhibitory effects of jaundice on regenerating liver.

The effects of partial hepatectomy on the energy charge (ATP + 1/2ADP/ATP + ADP + AMP) and mitochondrial oxidative phosphorylation were studied in normal and jaundiced rats. In normal rats and energy charge levels of the remnant liver decreased only slightly with a rise in the phosphorylative activity of the mitochondria at an early stage after hepatectomy, and then rapidly returned to normal. In jaundiced rats subjected to the common bile duct ligation the energy the energy charge levels of the liver decreased to approximately 0.800 from 0.849 of normal value, though their mitochondrial oxidative phosphorylation was within normal limits. In jaundiced rats the energy charge levels of the remnant liver after partial hepatectomy decreased markedly without a return toward normal. The mitochondrial phosphorylative activity increased to only about 50% of hepatectomized normal rats after partial hepatectomy. More than 70% of jaundice rats died within 24 hours after partial hepatectomy. It was suggested that the jaundice inhibits an enhancement of ATP generation to provide sufficient energy for high energy demand rather than the enery-requiring biosynthetic process in an early process of liver regeneration.

Adenine Nucleotides↗
PubMed1976

Different response of hepatic energy change and adenine nucleotide concentrations to hemorrhagic shock.

The adenine nucleotide and mitochondrial metabolisms of the liver were studied in hemorrhagic shock of rats. In reversible shock, the energy charge (ATP+1/2ADP/ATP+ADP+AMP) levels fell more rapidly than the total adenine nucleotide concentrations and decreased to 64% of controls 2 hours after shock. However, the oxidative phosphorylation of isolated mitochondira was only slightly inhibited. The energy charge levels were restored to normal values immediately when the shed blood was reinfused, while the concentrations of adenine nucleotides increased gradually and reached normal at 2 hours later. In irreversible shock which took up 70% or more of the withdrawn blood to maintain pressure of 40mm. Hg, the energy charge, adenine nucleotide concentrations and mitochondrial oxidative phosphorylation decreased considerably and were not restored by the reinfusion of the remainder of shed blood. It is suggested that the energy charge can respond rapidly to changes in an available oxygen and the adenine nucleotide concentrations and that an impairment of mitochondrial oxidative phosphorylation plays an important role in leading to irreversible hemorrhagic shock.

Adenine Nucleotides↗
PubMed1976

Significance of glucose tolerance as prognostic sign in hepatectomized patients.

Glucose tolerance was determined in fourteen patients with cancer of the liver. The patients with parabolic GTT patterns fared relatively better than did those with linear GTT patterns. In the patients with successful extended right hepatectomy, gradually increasing and long-standing hyperglycemia (linear GTT pattern) in response to an oral glucose load was not observed after hepatectomy and the insulin response was significantly greater than that in controls. However, in the patient with unsuccessful extended right hepatectomy, the linear GTT pattern continued for a more prolonged period after hepatectomy.

Adult↗
PubMed1976

Effect of insulin on mitochondrial oxidative phosphorylation and energy charge of the perfused guinea pig liver.

The effect of insulin was investigated in the isolated guinea pig liver perfused with Krebs-Ringer bicarbonate buffer containing red blood cells and albumin. In the mitochondria isolated from livers perfused with 10 units of insulin per hour, the phosphorylative activity with glutamate as a substrate increased to about 160 per cent of control 60 minutes after the beginning of perfusion (p less than 0.01). Such an enhanced phosphorylative activity was accompanied by increases in the respiratory control ratio, state 3 respiration, and P/O ratio. On the other hand, in the liver perfused with insulin, the levels of the energy charge and adenine nucleotide quotient increased to a significant degree as compared to the liver without insulin (p less than 0.01 and p less than 0.05, respectively). It is suggested that insulin plays an important role as a portal factor in regulating mitochondrial oxidative phosphorylation and the levels of the phosphorylated adenine nucleotides.

Adenosine Diphosphate↗
PubMed1975

Glucose intolerance after massive liver resection in man and other mammals.

The relationship between changes in glucose tolerance and in mitochondrial phosphorylative activity was studied after massive liver resection. In rabbits twenty-four hours after hepatectomy, when the phosphorylative activity in the mitochondria of the remnant liver was enhanced maximally, the blood glucose level did not increase significantly after glucose administration. Forty-eight hours after hepatectomy, when the phosphorylative activity decreased to a submaximal level, the blood glucose level increased gradually but without a return toward normal. About six weeks after partial hepatectomy, mitochondrial function returned gradually to normal levels and the glucose tolerance test results returned to within normal limits. Considering the previous report that an enhancement of mitochondrial phosphorylative activity is required for a later increase in nuclear DNA synthesis, it was suggested that the plateau pattern, with hypoglycemia, and the gradual increase, with a prolonged return toward normal, in the glucose tolerance test are indicative or marked enhancement of mitochondrial phosphorylative activity preceding an increase in nuclear DNA synthesis. The changes in the glucose tolerance test results in hepatectomized rabbits also were observed in rats and in man; however, they were more rapid in rats and slower in man. From these results it was suggested that the glucose tolerance test is very useful in the evaluation of the stage of regeneration in the liver remnant after massive liver resection.

Adenosine Triphosphate↗
PubMed1975

Oral glucose tolerance in patients with jaundice.

A glucose tolerance test was performed on 21 patients with jaundice. The glucose tolerance patterns were principally classified into a parabolic pattern characterized by the return toward normal within 120 minutes and a linear pattern with long-standing increase for more than 120 minutes. Of these, 13 patients showed the parabolic pattern and tolerated the operation well. The other eight patients showed the linear pattern. Of the latter, four patients died within three weeks postoperatively, and the others died without leaving the hospital following operation. From the results, it was suggested that the parabolic glucose tolerance pattern is indicative of compensated damage to the liver, while the linear glucose tolerance pattern shows critically decreased hepatic functional reserve. Experimentally, the close relationship between the severity of the derangement of metabolism in the mitochondria of the liver and the degree of glucose intolerance was studied in rats and rabbits with jaundice subjected to the ligation of the common bile duct. In rats with jaundice in which the phosphorylative activity is significantly higher than that in the mitochondria from the tissues of the liver deprived of endogenous insulin through portal blood, the parabolic patterns develop. In rabbits with jaundice in which the phosphorylative activity is considerably lower than that in the mitochondria from tissues of the liver deprived of endogenous insulin, the linear pattern occurs. It was suggested that the two distinct patterns in patients with jaundice are closely related to the severity of the derangement of the phosphorylative activity of the mitochondria.

Adult↗