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Biomedical subjects

T I Davidson

Publications and source records attributed to T I Davidson.

11 recordsLinked to original sources
PubMed1996

Laser therapy for breast cancer: MR imaging and histopathologic correlation.

PURPOSE: To investigate magnetic resonance (MR) imaging guidance of interstitial laser photocoagulation to treat primary breast cancer. MATERIALS AND METHODS: Twenty female patients with symptomatic breast cancers diagnosed at cytologic examination underwent interstitial laser photocoagulation by means of a single fiber prior to surgical excision. Gadolinium-enhanced T1-weighted three-dimensional fast low-angle shot (FLASH) MR imaging was performed before and after laser therapy (median, 48 hours; range, 24-96 hours). Following resection, tumors were mapped in detail histopathologically. The extent of disease, size of laser burn, and extent of residual tumor were correlated with MR findings. RESULTS: Twenty-seven tumors were detected at histopathologic examination in the 20 patients. Five patients had more than one invasive mass. Twenty-five of the 27 tumors were identified as discrete enhancing masses at MR. The two missed invasive foci were obscured on MR images by diffuse patchy enhancement that correlated with the presence of an associated extensive intraductal component. Early (4-hour) follow-up images failed to depict the laser effect. Later (24-96 hours) follow-up images depicted the laser-induced necrosis as a zone of nonenhancement within the residual enhancing tumor. The correlation coefficients (MR vs histopathologic analysis) for the laser-burn diameter and residual tumor were 0.80 and 0.86, respectively. CONCLUSION: Delayed gadolinium-enhanced MR images can help define the extent of laser-induced necrosis and residual tumor after interstitial laser photocoagulation therapy in breast cancer.

Adult↗
PubMed1994

Post irradiation sarcoma of soft tissue and bone.

Thirty-eight patients with sarcomas of soft tissue and bone which followed previous radiotherapy have been treated at the Royal Marsden Hospital between 1951 and 1992. The commonest reasons for initial radiotherapy were carcinoma of the breast and lymphoma, and the median time to development of sarcoma was 11 years. The only long term survivors were those who had complete surgical excision. Seven patients required forequarter amputation (30% of the extremity sarcomas) which reflects their frequent situation in the shoulder girdle and upper arm and the close proximity to the brachial plexus and vascular bundle. The overall prognosis was poor (5-year survival 30%) and probably reflects the poor prognostic factors (size, grade and tumour site) present at the time of diagnosis.

Adolescent↗
PubMed1993

Naevoid basal cell carcinoma (Gorlin's) syndrome.

The multiple naevoid basal cell carcinoma syndrome (Gorlin's syndrome) is an inherited multisystem disorder which affects not only the skin, but also the skeletal system and a variety of other tissues and organs. This is a report of the case of a 29 year old woman who presented with multiple advanced basal cell carcinomas. On the basis of a literature review, guidelines for management are suggested and the importance of early diagnosis and regular follow-up is emphasized.

Adult↗
PubMed1989

Long term venous access using a totally implantable drug delivery system in patients with cystic fibrosis and bronchiectasis.

A completely implantable, subcutaneous, venous access system (Port-a-Cath) has been used for antibiotic therapy in 26 patients with cystic fibrosis or bronchiectasis over a period of 45 months. During this period there were ten complications in eight patients and in four patients all or part of the system had to be replaced. Nevertheless, the actuarial median functional survival of the implanted system exceeded 30 months. The Port-a-Cath system provides longer periods of venous access and has a lower complication rate than conventional, percutaneous central venous lines.

Adolescent↗
PubMed1986

Factors influencing survival following fractures of the upper end of the femur.

Patients undergoing treatment for fractures of the upper end of the femur in a district general hospital over a 2-year period were analysed to identify preoperative illness, operative factors or postoperative complications associated with increased mortality. Both the mean age and mortality rate were higher than in many other reported series. The elderly diabetic was identified as a particularly high-risk patient. Dislocation following hemiarthroplasty was associated with advanced age and carried a formidable mortality.

Age Factors↗
PubMed1985

Self-inflicted burns: a 5-year retrospective study.

Forty-two patients who had attempted suicide by burning were admitted to the North West Thames Regional Burns Unit over a 5-year period. Over three-quarters of these patients had previous psychiatric illness and a quarter had previously attempted suicide. In no case was political or religious protest a motive. The number of non-Caucasians was higher than expected from population statistics and fatal burns were more common in this group. The mean age was 36 years and the overall mortality rate was 48 per cent. The mortality was not significantly higher than for accidental burns of comparable severity.

Adult↗
PubMed1985

Long-term venous access using a subcutaneous implantable drug delivery system.

To facilitate long-term venous access in patients receiving chemotherapy, a subcutaneous totally implantable system (Port-a-Cath, Phamacia) has been used in 14 patients. The method of implantation and the advantages over conventional central venous catheters are discussed. The expense of the system necessitates careful patient selection.

Antineoplastic Agents↗
PubMed1985

Angiosarcoma arising in a patient with Maffucci syndrome.

Maffucci syndrome comprises multiple enchondromas together with cutaneous haemangiomas. Review of the literature shows a 15-20% incidence of sarcomatous change in one or more of the enchondromas. Malignancy arising from the vascular component, however, has only been reported in one case. We present a further case where a patient with Maffucci syndrome presented with multifocal angiosarcoma.

Combined Modality Therapy↗