The role of tyrosine phosphorylation in cell growth and disease.
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Biomedical subjects
Publications and source records attributed to T Hunter.
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HLA typing for the A and B loci and radiographic examination of the sacroiliac joints were performed in 54 randomly selected patients with paraplegia or quadriplegia of more than 3 years' duration. The sacroiliac joints were abnormal in 24 patients. No association was found between any of the HLA antigens of the A and B loci and the sacroiliac joint changes. There was, however, an increased incidnece of sacroiliac joint changes in quadriplegic as compared to paraplegic patients.
Clinical and radiographic follow-up examinations were obtained on 12 patients with ankylosing spondylitis (AS) who had undergone total hip replacement (THR). Four of these patients had bilateral THRs performed. The mean follow-up of these 16 THRs was 89 months (range 7-144 months). The THR had achieved excellent pain relief in 15 hips. Postoperative ankylosis did not occur. One arthroplasty has to be removed because of the development of protrusio acetabulum.. Radiographic follow-up was obtained in 14 hips. Six were found to have moderate periarticular ossification which did not significantly affect function. In our experience the risk of postoperative periarticular ossification developing in patients with AS is not a contraindication to hip replacement.
A patient with severe skeletal and systemic involvement due to ochronosis is reported. On radiographic examination there was a linear density attached to the left lesser trochanter. The possible role of ochronotic pigment deposition in tendon, leading to metaplastic bone formation, is discussed.