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Biomedical subjects

T Hudson

Publications and source records attributed to T Hudson.

At least 109 records · Page 6Linked to original sources
PubMed1995

Medicaid. Will the public program neglect the poor to pay for the elderly?

If the policy-makers trying to fix Medicaid think they've thought of every angle, they should think about the situation of Peggy, a middle-class Illinois widow stricken with Alzheimer's disease, who's being forced to spend down her savings to get Medicaid coverage for her nursing home care. In fact, there are several million Peggys out there, and balancing their needs against those of the hard-core Medicaid poor may break a system that was never resource-blessed to begin with.

Adult↗
PubMed1995

Rural priorities. Hospital links and managed care contracts top the list.

CEOs of rural hospitals know that integrating their services is essential to survival. What's not clear is whether the steps many are now taking--hiring primary care doctors and partnering with other hospitals--will secure their future. Results from an H&HN survey on rural integration.

Attitude of Health Personnel↗
PubMed1995

Detection of expanded CAG repeats in bipolar affective disorder using the repeat expansion detection (RED) method.

Genetic factors are of major aetiological importance in Bipolar Affective Disorder (BPAD type I and II). The exact mode of inheritance of BPAD is unknown, but the recent demonstration of anticipation suggests that dynamic mutations could be involved in the clinical expression of the disease. We have used the repeat expansion detection (RED) method to test whether the anticipation in BPAD could be explained by the presence of expanded trinucleotide repeat sequences. Using a (CTG)10 oligonucleotide a significantly higher number of expanded CAG repeats were found in the genomic DNA of two independent samples of unrelated BPAD patients of Swedish and Belgian ancestry as compared with normal controls. The difference in repeat number was more consistent if data of the two samples of patients was pooled. In this study a CAG trinucleotide repeat expansion was associated for the first time with a major psychiatric disorder. It is possible that the CAG trinucleotide repeat expansion is involved in the clinical expression of BPAD and that it is the molecular basis explaining the phenomenon of anticipation observed in this disorder.

Aged↗
PubMed1995

Sequence analysis of the human hTg737 gene and its polymorphic sites in patients with autosomal recessive polycystic kidney disease.

DNA sequence analysis of the human Tg737 gene was performed in 36 patients with the autosomal recessive form of polycystic kidney disease (ARPKD). Coding exons and their adjacent splice sites were screened for mutations. Pathogenic exon or splice region mutations were not identified although one exonic and two intronic polymorphic sites were discovered. These results are in agreement with another study that has recently reported linkage to Chromosome (Chr) 6p21-cen in a set of 16 ARPKD families. STS mapping has localized the gene to a YAC contig that includes D13S175 on chromosome 13q12.1. The polymorphisms found in the htG737 gene will permit its future evaluation as a candidate gene for other recessive cystic renal diseases and as a modifier gene in human PKD.

Base Sequence↗