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Biomedical subjects

T Hudson

Publications and source records attributed to T Hudson.

At least 217 records · Page 12Linked to original sources
PubMed1991

Hospital-MD joint ventures move forward despite hurdles.

Although experts say joint ventures are not a financial cure-all for hospitals, hospital-physician partnerships continue to move forward on hospital agendas. Despite some of the regulatory and practical challenges facing would-be joint venturers, health care attorneys, hospital executives and consultants agree that well-planned joint ventures can reap significant rewards for all parties involved. From purchasing equipment together to arranging for joint ownership of an entire hospital, hospital administrators and physician groups are broadening the range of a business management tool with a successful track record. Says one hospital CEO involved in a joint venture with a competing institution, "What drives these things is what's in the best interest of the patients." Joint ventures, he concludes, are "going to be more and more a part of our future."

Financial Management, Hospital↗
PubMed1991

Attorneys fear patient transfer claims in malpractice cases.

Hospitals are facing a new legal hurdle: the possibility that plaintiffs' attorneys will allege the violation of a federal patient transfer statute as part of their medical malpractice cases. Since the patient transfer law was enacted in 1986, additional laws, including two amendments passed last year, have placed new requirements on hospitals.

Emergency Service, Hospital↗
PubMed1991

Informed consent problems become more complicated.

The advance of medical technology and heightened consumer awareness among patients are fueling a rise in some kinds of informed consent claims. Although these claims still make up a small percentage of the total, experts say plaintiffs' victories in two important California cases last year highlight problems in this area. The bottom line? "Judges are...a little bit more willing to hear the plaintiff's side," says one expert.

Communication↗
PubMed1991

Hospitals work to provide advance directives information.

With a deadline of Dec. 1 looming ahead of them, hospitals are beginning to prepare for compliance with a new federal law on advance directives. The Patient Self-Determination Act, passed as part of the federal budget last year, requires those institutions participating in Medicare and Medicaid to give information on advance directives for care. Beginning on that date, hospitals will have to ask whether every patient they admit has an advance directive--a living will or a durable power of attorney for health care.

Advance Directives↗
PubMed1991

Genetic resistance/susceptibility to mycobacteria: phenotypic expression in bone marrow derived macrophage lines.

Congenic strains of mice susceptible (B10A.Bcgs) or resistant (B10A.Bcgr) to BCG were established. Here we describe the model system which has been established to analyze the functional activities of macrophages in the two strains. We have immortalized bone marrow macrophages from B10A.Bcgs and B10A.Bcgr congenic strains of mice and derived cloned macrophage lines designated B10S and B10R, respectively. B10R and B10S cell lines exhibited surface markers and morphology typical of macrophages. B10S and B10R were similar in their phagocytic activity, in their level of c-fms, in their transforming growth factor beta (TGF beta) mRNAs expression, and in their expression of tumoricidal activity in response to interferon-gamma (IFN gamma) plus lipopolysaccharides (LPS). However, B10R macrophages expressed a higher level of la mRNA when activated with IFN gamma compared with B10S macrophages. Analysis of the bacteriostatic activity of the two cell lines revealed that B10R macrophages were much more active in inhibiting Mycobacterium smegmatis replication than B10S. To measure the intracellular destruction of bacilli, a bactericidal assay based on hybridization with an oligonucleotide probe specific for mycobacterial ribosomal RNA was designed. The results demonstrated that B10R macrophages were endowed with enhanced constitutive bactericidal activity as compared with B10S. In conclusion we have obtained macrophage lines from bone marrow of B10A.Bcgs and B10A.Bcgr mice that express to a similar extent functional and phenotypic characteristics of macrophages. However, we demonstrate that relative to B10S macrophages, the B10R macrophages have higher expression of la mRNA and that they are constitutively more active in expressing mycobactericidal activity.

Animals↗
PubMed1991

Optimization of automated hearing test algorithms: a comparison of data from simulations and young children.

A five-up, five-down automated staircase procedure was used to explore the effects of variable starting and stopping rules as they interact with infant behavior in influencing the accuracy and efficiency of infant auditory threshold testing. Results from 146 infants were compared to results from computer simulations (see accompanying article) in order to evaluate an infant response model used in the simulations. Results indicate that the automated procedure successfully discriminated between infants with normal versus abnormal tympanograms. In addition, the model accurately predicted infant results in terms of the effects of starting and stopping rules. The model was less useful in predicting the relationship between minimum response levels and false positive rates.

Algorithms↗