Biomedical subjects

T Horváth

Publications and source records attributed to T Horváth.

At least 19 recordsLinked to original sources

PubMed2001

Bacteriological recovery after intramuscular or intracisternal spiramycin-based drying-off therapy.

Systemic (intramuscular, i.m.) vs. local (intracisternal, IC) routes of spiramycin-based drying-off therapy were compared for efficacy on 65 Staphylococcus aureus infected udder quarters of 38 dairy cows. Single-dose (30,000 IU/kg) i.m. treatment (single i.m. group) resulted in a similarly low bacteriological recovery rate (14%) as seen in the untreated controls (18%). I.m. treatment (30,000 IU/kg) on 4 consecutive days (4 i.m. group) resulted in significantly higher quarter-based recovery rates than that in the single i.m. group. The bacteriological recovery rates obtained in the intracisternal and 4 i.m. groups were quite similar but remained below 50%. Based on these findings as well as on the high cost of the repeated intramuscular treatment regime there is no reason to give extra preference to the systemic application of spiramycin at drying off in the practice.

Animals↗

PubMed1997

[Pancreatogenic panniculitis based on 2 cases].

The rarest and hardly known complication of pancreas diseases is the subcutaneous nodular fat necrosis, a special type of panniculitides. It is mostly associated with pancreatitis and adenocarcinoma of pancreas. Its diagnostic criteria are (1) red painless or occasionally painful nodules showing a tendency of coalescence, emolition and fistulation on the lower extremities and later anywhere on the body, (2) alcoholic case-history, (3) tense, painful joints, (4) elevated pancreatic enzyme levels in the blood and urine. Since the underlying pancreas diseases may be asymptomatic, the pancreatogen panniculitis should be considered as a noteworthy marker of them. The histologic findings are pathognomic. In pancreatogen panniculitis in all likelihood the remote foci of adiponecrosis are due to the local action of pancreatic lipolytic enzymes carried by the blood. The question has not been settled yet. In this article there are presented two cases of pancreatogen panniculitis, recognized by the consultant dermatologist. Referral diagnoses of both cases were misleading: "erythema nodosum" in the first case and "drug eruption" in the second one. The determinant underlying pancreas disease in both cases was pancreatitis with pseudocyst resulted from alcoholic toxicomany.

Adipose Tissue↗

PubMed1997

Epidemiology of congenital coronary artery anomalies: a coronary arteriography study on a central European population.

The anatomical patterns and frequency of occurrence of congenital coronary anomalies (CCA) in a Central European cohort has not yet been studied. The angiographic data of 7,694 consecutive patients undergoing coronary arteriography at the Albert Szent-Györgyi Medical University, Szeged, Hungary, from 1984 to 1994 were analyzed. CCA were found in 103 patients (1.34% incidence). Ninety-eight of them (95.2%) had anomalies of origin and distribution, and five (4.8%) had coronary artery fistulae. The incidence was the highest for the separate origin of left descending artery and left circumflex from the left sinus of Valsalva (52.42%). Anomalous origin of the left circumflex coronary artery from the right coronary was 8.7% while from the right sinus of Valsalva 18.4%. CCA, which may be associated with potentially serious events, such as ectopic coronary origin from the opposite aortic sinus (1.9%) and single coronary arteries (3.88%), were not frequent. The incidence of CCA in the Central European cohort under study was similar to that of the largest North American study. The anatomic classification presented can be useful from both clinical and surgical standpoints.

Adult↗

PubMed1996

[Correlations between clinical picture and coronary angiography in unstable angina].

In a one year period (from 01.07. 1993 to 30. 06. 1994) 103 patients were admitted to the Central Intensive Care Unit of the Albert Szent-Györgyi Medical University with the diagnosis of unstable angina. In this cohort of patients the authors assessed the correlation of clinical and angiographic data. Significant coronary artery disease was found in 84% (85 patients), single-vessel disease in 23% (24 patients), double-vessel disease in 38% (29 patients), triple-vessel disease in 20% (21 patients), left main stenosis in 8% (8 patients). The culprit lesion was determined in 73 cases. The distribution of the culprit lesion severity was the following: 50-70% in 17% (12 cases), 70-90% in 27% (20 cases), greater than 90% in 44% (32 cases), 100% in 12% (9 cases). Simplex lesions were seen in 43 cases, complex lesions in 9 cases, diffuse irregularities in 5 cases and total occlusions in 9 cases. Abnormalities indicating intracoronary thrombin-us were seen on 5 coronarograms. No correlation could be demonstrated between the clinical classes according to Braunwald and the angiographic morphology.

Adult↗

PubMed1994

[Non-traumatic intrahepatic bile-duct perforation in an adult].

Authors report a case of a patient suffered from intrahepatic bile duct perforation caused by stenosis of the papilla of Vater. With the help of data of medical literature there are analysed the etiological factors of bile duct perforations and the pathological process that leads to perforation. There is emphasized that the only way to avoid the sepsis and other postoperative complications on operation carried out in an early time and the supplemented intensive care. Authors call attention for the importance of carefully carried out intraoperative revision of bile system in cases of biliary peritonitis.

Ampulla of Vater↗

PubMed1993

[The place of percutaneous transluminal angioplasty in the management of obliterative vascular diseases of the lower extremities. Femoro-popliteal arterial angioplasty].

Authors treated 331 patients having symptoms of femoropopliteal stenoses or occlusions with transluminal angioplasty from 1983. They performed 186 dilatations and 189 recanalizations. Procedures were preceded by medicinal preparation. The primary technical success rate was 94.6% after dilatation, and 79.9% after recanalisation. In case of stenosis the success rate did not show significant connection with the length of the dilated segment but in case of occlusion longer than 6 cm the success rate decreased. After procedure 87.2% of the patients became asymptomatic, or improved. 21 (5.6%) complications (7 inguinal hematomas, 6 emboles, 6 thromboses, one perforation of arterial wall) occurred and twelve of them required surgical intervention. One patient died after angioplasty due to cardiac failure. Authors are of the opinion that femoropopliteal occlusions and stenoses shorter than 6 cm should be treated by angioplasty. They suggest making balloon catheter dilatation for multiple stenoses even they are longer than 6 cm.

Aged↗

PubMed1993

[Functional treatment of humeral diaphyseal fractures using a Hungarian-manufactured brace].

Authors suggest, in their paper, a new method in this country, the so called brace treatment for the functional treatment of the diaphyseal fractures of the humerus. A 2-4 fifth of the diaphyseal fractures of the humerus can be treated in the majority with this method. An other novelty of this treatment is the humerus brace developed and manufactured in Hungary. This fracture treatment has unequivocal advantages both for the health service and the patient for its shorter duration of healing and treatment.

Adult↗

PubMed1992

[The place of percutaneous transluminal angioplasty in the treatment of obliterative vascular diseases of the lower limbs. Angioplasty of of the iliac system].

Between 1983-91 386 patients with hemodinamically significant stenosis or short-segment occlusion of iliac arteries were treated by transluminal angioplasty. 487 dilatations and 13 recanalizations were performed. In 353 (70.2%) of these cases were carried out without medicinal preparation continuously after the diagnostic angiography. The technical success rate was 93.4%. The technical success rate did not depend on medicinal preparation. 93% of their patients became symptomless or improved. 28 complications were noted (7 thrombosis, 4 embolisms, 14 inguinal haematomas, 2 false aneurysms, 1 bleeding), 11 of them required surgical intervention. One patient died because of cardiac failure due to retroperitoneal haematoma. Authors' opinion isolated short uni- and bilateral iliacal stenosis can be treated by transluminal angioplasty. Longer or multifocal stenosis required individual consideration.

Aneurysm↗

PubMed1992

[Treatment of pancreatic pseudocysts with ultrasound-guided percutaneous puncture and drainage].

The authors have treated 37 pancreatic pseudocysts in 36 patients by ultrasonically guided percutaneous puncture and drainage. The indication for intervention was rapid enlargement or threatening rupture of the acute (younger than 6-8 weeks) pseudocysts with recurring fever in 5 cases and chronic pseudocysts causing abdominal symptoms in 32 cases. After puncture six of seven patients were recuperated, but later in three of them the pseudocysts recurred. In one case as a complication of the puncture the pancreatitis exacerbated and led to death of the patient. The outcome of percutaneous drainage was successful in 26 of 32 pseudocysts. During the follow-up (6-54 months) recurrence were observed without symptoms in three cases. In four patients the treatment was ineffective, therefore cystogastrostomy was performed. During the time of the percutaneous drainage two pseudocysts had been infected and abscesses developed, which were treated by oncotomy. On the basis of their favourable experiences the authors recommend the US-guided percutaneous durable drainage as primer intervention for treatment of the pancreatic pseudocysts causing symptoms.

Aged↗

PubMed1992

Endogenous scavenger levels (vitamin E and A) of patients with chronic alcoholic liver disease under different environmental conditions.

Serum level of endogenous scavengers (E and A vitamin) was studied in groups of patients with various chronic alcoholic liver diseases and in a healthy control group on polluted and non-polluted areas. Vitamin levels in patients with chronic liver disease are diminished in comparison to the healthy in general, but mainly in the cirrhotic group. Diminution of vitamin E levels was observed in earlier phase of liver disease than that of vitamin A levels. Patients and healthy control on polluted area showed more expressed diminution of vitamin levels than the same groups on non-polluted area. Free radical parameter (RBC diene conjugate content) and characteristic alcoholic parameters (serum GOT, gamma-GT, cholesterol level and liver GOT, gamma-GT content in biopsy specimen) were used to explain the differences between the same investigated groups on polluted and non-polluted areas. As conclusion can be supposed that industrial pollution of environment has a worsening effect in diseases with free radical mechanism.

Cholesterol↗

PubMed1992

DNASK--a new image analysis module for TV image cytometry.

The DNASK is a PC-based image analysis module for quantitative cytological and histological examinations on Feulgen-Schiff preparations. The module consists of a frame grabber, a CCD black and white video camera and the DNASK software package which can be incorporated in an IBM compatible PC-AT joining to a standard pathological research photo microscope. The use of 386 IBM AT systems leads to significant decrease of the measurement's time. Mono- or color VGA graphics card should be used. The resolution of the images is 512 x 512 pixels and 256 gray values. The image caption is made in less than 0.5 second, the measurement of a cell nuclei (18 parameters) takes less, than 5 seconds (IBM AT 286). The camera is a standard CCD one. The microscope should be a good quality, modern microscope with built-in light source, however, the application of voltage stabiliser is strongly recommended. The software is able to measure the parameters mostly used and suggested in the international literature: 15 morpho- and densitometric parameters of the cell nuclei 6 DNA histogram parameters of the measured case, like DNA Index, 2c deviation Index, 5c exceeding rate, G1-S-G2 phase fraction ratio. The system supports the grouping of the measured cases and at the end of a study results of the single measurements can be collected and summarized in an ASCII file, which is readable by major statistical programpackages. The DNASK has a special graphical user interface for the control of the program.

Algorithms↗

PubMed1991

[Successful intraoperative angioplasty in bilateral fibromuscular dysplasia of the internal carotid arteries].

The authors report the clinical history of a 55-years old woman suffering from the multiplex stenosis of both internal carotid arteries caused by fibromuscular dysplasia. Successful intraoperative angioplasty was performed. In connection with their case the authors review briefly the clinical feature, diagnosis and therapy of fibromuscular dysplasia of the internal carotid artery.

Angioplasty, Balloon↗

PubMed1991

[Typhlitis as a complication of acute leukemia].

The authors describe the clinical history of two adult patients with acute myeloid leukemia, who had severe neutropenia and thrombocytopenia. After chemotherapy in both patients had developed typhlitis with fatal outcome caused by sepsis. They discuss the etiopathogenesis and clinical features of necrotizing typhlitis as a complication of treated acute leukemia and point out the difficulty of the differential diagnosis and management.

Adult↗

PubMed1990

[The role of intraoperative angioplasty performed simultaneously with reconstructive vascular surgery].

21 arterial lesions were dilated intraoperatively in conjunction with primary vascular reconstructive procedures. Of these, five involved the iliac vessels, fourteen the femoropopliteal segment, one the subclavian artery and one the common carotid artery. 19 intraoperative balloon dilatations were successful and two were unsuccessful. Only one catheter-related complication were noted, it was a perforation of the wall of the artery caused by guidewire. No deaths occurred as a result of the combined procedure. Attention is drawn to the advantage of the intraoperative balloon dilatation and the authors recommend it on adequate conditions and correct indication.

Adult↗

PubMed1990

[Reconstruction possibilities in obliterative arterial diseases in diabetics].

Authors treated 144 diabetic patients with arterial angiopathy localised to the lower extremities. 114 cases belonged to III. and IV. stages. There was a possibility in 55 (38.2 per cent) for reconstructive surgery, 80 per cent of the reconstructive procedures localised to the femoro-popliteal region. In 20 cases a so-called "high", in 61 a "low" (minor) amputation was performed, 14 patients died. In 113 cases (78.47 per cent) an improvement or a cure could have been achieved, of whom 52 with the complete preservation of the extremity, and in the others after necrectomy or minor amputation. Authors emphasize that, in more than a half of the cases the obstruction localised to the femoropopliteal and iliacal region, so the possibilities of the vascular surgery are given in a considerable number of diabetic patients.

Amputation, Surgical↗

PubMed1990

[Experience with the surgical treatment of superficial thrombophlebitis (varicophlebitis)].

107 patients with acute varicophlebitis of the lower limbs have been treated. In 101 cases operation were performed. These patients were treated by surgical excision of the thrombosed segments, with excision or stripping of the remaining varicosities and high saphena ligature. There were no postoperative deaths. One male patient experienced nonfatal minor pulmonary embolism. Wound-healing disturbances were observed in only 11 patients. Attention is drawn to the advantage of the surgical management. Regarding the good experiences, the authors recommend the performance of the "acute" varicectomy.

Humans↗

PubMed1989

[Management of malignant pleural effusion by tetracycline pleurodesis].

Eleven patients were treated with chest tube drainage and intrapleural instillation of tetracycline for malignant pleural effusion. In ten cases this procedure for 6-10 days achieved complete resolution of pleural fluid and produced pleurodesis. Only one patient needed longer treatment, but it was also successful. Fluid recurrence was not recognised during the follow-up period. This method is very effective and simple, so the authors recommend the tetracycline pleurodesis for the palliative management of malignant pleural effusions.

Breast Neoplasms↗

PubMed1989

Drug metabolism in drug-induced liver diseases: pathogenetic role of active metabolites.

Three cases with drug-induced liver diseases (hepatitis caused by hydralasine, steatosis caused by methimazole, choletasis caused by birth control pill) were investigated with respect to their drug metabolising ability. Clinical diagnoses were based on the exclusion of other pathogenetic factors, on histological findings of liver biopsy specimens and on the clinical chemical tests. Investigation of biotransforming ability was carried out using test materials (menthol loading, antipyrine, sulfadimidine, caffeine, indocyanine green kinetics) and measurement of D-glucaric acid excretion. In all cases the results show a defective capacity in some respect of drug metabolism. Possible pathogenetic role of reactive metabolites is discussed in the pathomechanism of genesis of drug-induced liver diseases.

Adult↗