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T Horai

Publications and source records attributed to T Horai.

At least 73 records · Page 4Linked to original sources
PubMed1983

[Chemotherapy of small cell carcinoma of the lung in relation to lymph node metastasis and extending pattern of tumor].

Chemotherapeutic effects on the lymph node metastasis were studied in relation to the predominancy of T or N factor, extending patterns of tumor, histologic subtype, and cytologic characteristics, using cyclophosphamide, vincristine and 5-FU. N2, N3, N4 indicate ipsi-lateral, contra-lateral mediastinal, and supra-clavicular node, respectively. Chemotherapy was equally effective to the lymph node metastasis regardless a degree of progression, but survivals depended on the progression. Predominancy of both primary tumor (T) and involved lymph node (N) was analysed on chest X-rays. The Deffer response was observed in Type N than in Type T. Extending patterns of primary tumor were classified on X-ray films according to Suzuki's criteria: a longitudinal submucosal spreading along the bronchus (I): infiltration beyond the bronchial wall, extending to the depth, and fusing into a mass (III): and intermediate (II). In type I, the tumor was seen like an assembly of clubs extending along the bronchial tree, and Type III tumor showed a mass-like shadow with relatively high density and clear margin. Overall response rates were remarkably higher in Type I and lower in Type III. Type I was more frequently accompanied by large lymph node involvement than Type III. The highest response rate was obtained in Type I with N-predominancy and the lowest in Type III with T-predominancy. Responses to chemotherapy of lymph node metastasis depended upon these extending patterns. A half of Type III cases were polygonal cell type, which showed the lowest response rate in our institute. Regarding to cytologic classification by Horai, 67% response of good was found in Type I and 65% of response poor in Type III. These biological characteristics are considered to be a useful indicator for the selection of treatment modalities.

Carcinoma, Small Cell↗
PubMed1983

[Cellular changes in malignant pleural effusion induced by intrapleural injection of BCG-CWS].

The intrapleural injection of BCG cell wall skeleton (BCG-CWS) is thought to be beneficial in the treatment of malignant pleural effusion. The study of cancer cells in pleural effusion after the intrapleural injectin of CWS showed that nuclear damage to cancer cells was slight and delayed compared to findings obtained after the intrapleural injection of Mitomycin C. After the intrapleural injection of CWS, the ratio of granulocytes in pleural effusion was rapidly elevated. This suggests that CWS induces an inflammatory response in the pleural cavity. After the inflammatory reaction, adhesive pleuritis was induced, the pleural space was reduced, leading to the disappearance of effusion. On the other hand, after the intrapleural injection of CWS, no elevation of the ratio of macrophages, and no increase of macrophage and cancer cell adherence were observed. This suggests that the immunopotentiating effect of CWS is not high.

Adenocarcinoma↗
PubMed1982

[Cytologic studies in relation to the effect of treatment of lung cancer].

Since the diagnosis of lung cancer is made cytologically in most instances, the study of cytologic materials of lung cancer may be useful to plan the treatment schedule, to judge the effect of treatment and to find the recurrence of the lesion in central type lung cancer. Shibata et al. observed the correlation of morphologic changes of irradiated cancer cells and radiation doses, and found the close relation between them. In order to detect disappearance of cancer cell in the cytologic specimens, more than over 1000 r. was necessary for small cell carcinoma, more than 2000 r. For large cell carcinoma, more than 3000 r. For squamous cell carcinoma and more than 5000 r for adenocarcinoma, respectively. It suggests that small cell carcinoma is more radiosensitive. To predict the degree of response to radiotherapy, it is most important to decide the cell typing of obtained cancer cells. We investigated whether certain cytologic characteristics of small cell carcinoma could be correlated with response to chemotherapy. The cancer cells in the good response group more frequently showed finely granular chromatin evenly distributed through the nuclei. The cancer cells in the no/response group predominantly showed deeply stained nuclei with coarsely granular chromatin distributed evenly or pale nuclei with unevenly distributed chromatin. These findings may be an indicator to predict the degree of response to chemotherapy. Cytologic grading of irradiatic changes reported by Shibata et al. may be useful for judging the effect of treatment of lung cancer. We introduce three cases of lung cancer in this paper and reported the correlation of morphologic changes of cancer cells and the effect of treatment of those cases.

Aged↗
PubMed1981

Glycosaminoglycans in human lung cancer.

The quantitative changes of glycosaminoglycans in tumor tissue of human lung cancers (2 squamous cell carcinomas, 4 adenocarcinomas and 5 small cell carcinomas) were studied. The total amount of glycosaminoglycans in human lung cancer tissues increased 1.4 to 4 times in comparison with that in normal lung tissues. The increase in tissue content of glycosaminoglycans was accompanied by an increase in the chondroitin sulfate level in every histologic type of lung cancer, as well as by a marked increase in hyaluronic acid level in squamous cell carcinomas, and a moderate increase in its level in small cell carcinomas. The concentrations of dermatan sulfate and heparan sulfate in lung cancer tissues did not show any significant changes compared with those in normal lung tissues. The increase in total amount and changes in the composition of glycosaminoglycans in human lung cancer tissue were closely related to the histologic type of the tumor.

Adenocarcinoma↗
PubMed1981

Cytologic characteristics of oat-cell carcinoma of the lung in relation to the effect of chemotherapy.

The cytologic study of the effect of chemotherapy was performed in oat-cell carcinoma of the lung. Cellular characteristics of tumor cells obtained by brushing via bronchoscopy were compared between responders (13 patients in complete and partial regressions) and nonresponders (13 patients with no response) treated with cyclophosphamide. The tumor cells in the responders more frequently showed finely granular chromatin evenly distributed throughout the nuclei. The tumor cells in nonresponders showed predominantly either deeply stained nuclei with coarsely granular chromatin distributed evenly or pale nuclei with unevenly distributed chromatin. These findings were also applied in the evaluation of the effect of combination chemotherapy. The nuclear chromatin pattern from oat-cell carcinoma of the lung may be an indicator to predict the degree of response to chemotherapy.

Aged↗
PubMed1981

Combined modality studies on small cell carcinoma of the lung - current status in Japan.

Sixty-two patients with small cell carcinoma in three institutes were carefully divided into limited and extensive disease categories. Median survival time of limited-disease patients was longer than those with extensive disease. In relation to the survival rate, the degree of response to initial chemotherapy was studied on 75 patients treated in our institute. The complete responders had a significantly better survival rate than the partial responders and nonresponders. Best survival was achieved by multidisciplinary treatment, including polychemotherapy, subsequent radiotherapy, and immunotherapy using BCG-CWS or Nocardia-CWS. Combination chemotherapy with concurrent small-dose radiation therapy for the purpose of intensifying the effect of chemotherapy was introduced. This method significantly improved the response rate without causing any of the side effects associated with radiotherapy. Cytomorphological studies on the correlation with better survival rates of small cell carcinoma patients were described.

Antineoplastic Agents↗
PubMed1979

Malignant melanoma producing serotonin.

A case of malignant melanoma, the tumor of which seems to produce serotonin, is presented. Neither hyperserotoninemia nor carcinoid syndrome was observed in the clinical course. An autopsied sample of the metastatic lung tumor contained a significantly higher concentration (1.35 microgram/g wet weight tissue) of serotonin than that of normal lung (below 0.5 microgram wet wt.). Tryptophan hydroxylase activity, the key enzyme of the biosynthesis of serotonin, was substantial in the same tumor sample when assayed by a sensitive radioisotopic method, supporting the productivity of the amine of the tumor. The ability of melanoma to produce serotonin could be attributed to its neural crest origin.

Adult↗
PubMed1978

Demonstration of argyrophil granules in small cell carcinoma of the lung.

The Grimelius silver nitrate stain has enabled us to demonstrate the presence of tumor cells with argyrophil granules (argyrophil cells) in small cell carcinoma of the lung. Of the 22 tumors, 11 showed varying numbers of argyrophil cells. The occurrence of the cells differed in frequency among the subtypes of small cell carcinoma. The fusiform cell type showed the cells more frequently than the other types. Both tumors with numerous argyrophil cells belonged to the fusiform cell type. The number of positive cells seen under the light microscope did not correlate with the number of cells containing neurosecretory granules under the electron microscope, nor with the amount of either ACTH or serotonin in the tumor extracts. The demonstration of these cells in a pulmonary carcinoma may be of help in making correct histological diagnosis.

Adrenocorticotropic Hormone↗
PubMed1978

Production of several substances by medullary carcinoma of the thyroid.

Two patients with the typical morphology of medullary carcinoma of the thyroid are reported. Biochemical analysis of the tumor tissue demonstrated the presence of calcitonin, ACTH and MSH, although symptoms referable to these hormones were hardly manifested. Serum CEA levels were elevated and CEA immunofluorescences in the tumor cells were positive. Moreover, in one patient, serotonin concentration was raised in the tumor tissue, and gastrin level was also elevated in the peripheral blood. These results suggest that the tumors may produce several substances.

Adult↗
PubMed1978

A cytologic study on small cell carcinoma of the esophagus.

The cytologic picture of small cell carcinoma primarily arising from the esophagus was studied with 7 cases which were confirmed by histologic examination. Cytomorphologic characteristics of small cell carcinoma of the esophagus are as follows: the arrangement of groups of tumor cells is irregular and overlapping with indistinct cell boundaries. The cytoplasm is small, or sometimes absent. The nuclei are round, oval or occasionally spindle shaped. Nuclear borders are thin. The chromatin of finely granular pattern has increased and is evenly distributed.

Aged↗
PubMed1976

Argyrophil cell carcinoma (apudoma) of the esophagus. A histopathologic entity.

In a series of 79 cases of primary esophageal carcinoma resected at The Center for Adult Diseases, Osaka, there were six tumors with specific histopathologic features valid for the diagnosis of argyrophil cell carcinoma. Of the 6 tumors, 3 were studied electron microscopically and assay for ACTH content was performed on 4 tumors. Clinically, the ages of the 6 patients ranged from 56 to 71 years; two were women and four men. Four of the 6 patients died with widespread tumor recurrences within 9 months of operation. Microscopically, the 6 tumors were composed largely or almost entirely of small, spindle-shaped cells resembling those of oat cell carcinoma of the lung, and were characterized by the arrangement of tumor cells in solid sheets or anastomosing cords, the presence of argyrophil tumor cells, and the deposits of amyloid. Electron microscopically, the three tumors contained neurosecretory-type granules. Using bioassay or radioimmunoassay ACTH activity in the tumor tissues was detected in 3 out of the 4 tumors determined. From the light and electron microscopic characteristics and the assay evidence, it seems reasonable to conclude that the 6 tumors are endocrine polypeptide producing tumors (apudomas) that arise from argyrophil cells normally found among the basal cells of the esophageal mucosa, and that they represent a distinct histopathologic entity clearly distinguishable from other types of esophageal carcinomas.

Adrenocorticotropic Hormone↗