Biomedical subjects

T Hirota

Publications and source records attributed to T Hirota.

330 records · Page 19Linked to original sources

PubMedDate not supplied

Cytologic diagnosis of breast carcinoma with nipple discharge: special significance of the spherical cell cluster.

In order to investigate the cytologic characteristics of breast carcinoma in nipple discharge, 190 histologically proven cases of various breast lesions from 2,723 samples of nipple discharge were studied. The general criteria of malignancy as described for other organs applied also to the breast carcinoma cells. However, the breast carcinoma cells were generally smaller and less pleomorphic than those arising from other organs. In addition to the malignant features of individual tumor cells, the presence of a spherical cell cluster with a smooth rim was also an important finding suggestive of malignancy. The diagnostic rate of breast carcinoma increased significantly when the 190 cases were reexamined on the basis of the findings of this study.

Breast↗

PubMedDate not supplied

Comparative studies on the histogenesis of squamous carcinoma of esophagus in mice and in human subjects.

Histological changes occurring in the esophageal mucosa of 110 C57b1 mice, after protracted topical treatment with diethylnitrosamine, were compared to those present in human esophagus in three patients operated for early esophageal cancer. Both in mice and in human material, the histological changes were classified into slight, moderate or severe dysplasia, carcinoma in situ, questionable invasive carcinoma and invasive carcinoma. Starting from moderate dysplasia, the epithelial-stroma border became irregular with bud formation bulging into the stroma. The findings strongly suggest an association between the degree of cellular atypia, the formation of epithelial buds, and progression towards invasive carcinoma.

Animals↗

PubMedDate not supplied

Flat serrated adenomas of the colorectal mucosa in Japanese patients.

While reviewing the histological sections of 319 flat colorectal polyps at three different Hospitals in Tokyo, 7 cases of flat serrated adenomas were found. Flat serrated adenomas differ histologically from flat tubular adenomas. In the former the dysplastic cells are found initially at the lower part of the crypts of Lieberkuhn, and the epithelium of the sides of those crypts have serrated infoldings without dysplastic cells. In flat tubular adenomas, however, the dysplastic cells are initially found in the upper part of straight crypts (i.e. without epithelial infoldings). Six of the 7 serrated adenomas had low grade dysplasia (LGD) and the remaining one high grade dysplasia (HGD). Atypical mitosis were present in the dysplastic epithelium of serrated adenomas. Depending upon the topographic distribution of the dysplastic epithelium within the crypts flat serrated adenomas were divided into Type I, where the dysplastic epithelium was limited to the lower half of the serrated crypts, and Type II where the dysplastic epithelium was present even in the superficial half of the serrated crypts. Of the 7 serrated adenomas, 3 were Type I and the remaining 4 Type II lesions. The dysplastic epithelium seemed to have originated at the base of the crypts and progressed upwards, replacing the scalloped, serrated epithelium. Flat serrated adenomas appeared as benign lesions upon endoscopy (their pit pattern being identical to flat hyperplastic polyps), but in a previous survey of Swedish patients 3 of 47 flat serrated adenomas had invasive adenocarcinoma (i.e. with submucosal extension). Whether serrated adenomas evolved into invasive carcinoma in the Japanese should be assessed in a larger series of cases.

Adenoma↗

PubMedDate not supplied

Monitoring and regulating latissimus dorsi muscle performance for circulatory assist.

The purposes of this study were monitoring and regulating latissimus dorsi muscle (LDM) performance with muscle internal pressure and thickness, and with burst stimulation parameters, respectively. The unconditioned LDM flap of a pig was connected to a measurement system to examine force and contraction length. Internal pressure was measured using a catheter pressure transducer with a fluid-filled balloon inserted into the muscle, and correlated linearly with force during both contraction and relaxation. During contraction, thickness change correlated linearly with contraction length and the area enclosed within an internal pressure-thickness curve, and the X-axis was correlated linearly with muscle work. Stroke work increased incrementally according to the pulse width up to 6.72 msec or burst rate up to 120 Hz, and then plateaued at 240 Hz. The authors conclude that muscle work during contraction could be monitored with internal pressure and thickness, and that stroke work could be regulated with pulse width or burst rate.

Animals↗

PubMedDate not supplied

Intraepithelial lymphocytes in flat colorectal adenomas.

The occurrence of intraepithelial lymphocytes (IELs) was investigated in 118 flat colorectal adenomas. IEL infiltration was recorded in 61.9% or in 73 of the 118 flat adenomas. Of the 58 flat adenomas with LGD, 30 (or 51.7%) had IELs, and of the 60 flat adenomas with HGD, 43 (71.7%) had IELs. The significance of IELs in flat colorectal adenomas remains obscure. The finding that the epithelium of flat adenomas with HGD had more IELs than the epithelium of flat adenomas with LGD suggests that the degree of IEL infiltration may increase with increasing degree of epithelial severity in adenomas. One possible implication from this work may be that immunologic mechanisms orchestrated by the host and directed towards the neoplastic cells, may be acting at the early stages of colorectal carcinogenesis.

Adenoma↗

PubMedDate not supplied

Ethnic or environmental differences in disparate geographic regions may influence the histology of flat colorectal neoplasias.

Histologic sections of endoscopically flat colorectal polyps removed in Tokyo and Stockholm were reviewed. A total of 178 flat colorectal neoplasias (88 from the Tokyo Medical College Hospital, Tokyo and 90 from the Karolinska Hospital, Stockholm) were classified following strict histologic criteria by two different pathologists (one Swedish and the other Japanese). The number of polyps with high grade dysplasia, with intramucosal carcinoma and with invasive carcinoma were significantly higher (p < 0.001) in Tokyo (61.4% or 54/88) than in Stockholm (15.0% or 14/90). The present results suggest that flat colorectal neoplasic polyps may be histologically more "severe" and more "aggressive" in Japanese than in Swedish patients. The possibility that more "advanced" lesions had been inadvertently removed in Tokyo was discounted as Japanese endoscopists were also instrumental in excising many of the flat colorectal polyps in Stockholm. Ethnic and/or environmental differences seem to play a crucial role in the evolution of flat colorectal neoplasic polyps from LGD and HGD, to intramucosal and to invasive carcinoma.

Adult↗