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Biomedical subjects

T Hirata

Publications and source records attributed to T Hirata.

At least 523 records · Page 29Linked to original sources
PubMed1979

PPD-induced immunoglobulin production in human peripheral blood lymphocytes. II. Separation of PPD-reactive helper T cells from PWM-reactive helper T cells in polyclonal immunoglobulin production of human peripheral blood lymphocytes.

We investigated the relationship bewteen PPD-reactive helper T cells and PWM-reactive helper T cells in polyclonal Ig production of human PBL. Elimination of PPD-reactive T cells by BUdR + light treatment resulted in a loss of helper function in PPD-induced Ig production, but had no effect on helper function in PWM-induced Ig production. On the other hand, elimination of PWM-reactive T cells resulted in a loss of helper function in both PPD-induced Ig production and PWM-induced Ig production. A blast cell-enriched fraction that was generated by PPD and separated by the velocity sedimentation method contained helper function in both responses. On the other hand, blast cell-depleted fractions did not contain PPD-reactive helper function, although the PWM-reactive helper function was evident. These results strongly suggest that PPD-reactive helper T cells are included in PWM-reactive helper T cells.

Bromodeoxyuridine↗
PubMed1978

Potential CNS antitumor agents-phenothiazines II: fluphenazine analogs.

Fluphenazine was found to possess moderate reproducible activity against the intraperitoneal L-1210 and P-388 leukemia murine tumor models. Seven ether derivatives of fluphenazine and eight compounds in which the terminal side-chain hydroxyl group was replaced by an amine function were prepared and evaluated in the intraperitoneal L-1210, P-388, and B16 melanoma systems as well as the intracerebral L-1210 and ependymoblastoma brain tumor models. While no substantial intracerebral activity was observed, seven derivatives possessed reproducible activity in the intraperitoneal L-1210 or P-388 system. Several gave T/C values of 150%. No B16 melanoma activity was observed. These compounds were also tested for their cytotoxic properties in culture against L-1210, P-388, and KB cells. The amine isosteres, while possessing little in vivo activity, were the most cytotoxic of the compounds prepared, with several having ED50 values less than 1 microgram/ml.

Animals↗
PubMed1978

Inhibition of gastric secretion by intraduodenal hypertonic glucose in patients with duodenal ulcer.

Intraduodenal instillation of hypertonic glucose significantly inhibited tetragastrin-induced gastric acid and pepsin outputs in man. The secretory volume of gastric juice was markedly decreased, whereas, acid concentration remained unchanged. Pepsin concentration, on the contrary, was reduced significantly. The degree of inhibition of pepsin output, therefore, was greater than that of acid output. No significant difference in the extent of inhibition of acid or pepsin output was observed between control subjects and patients with duodenal ulcer.

Adult↗
PubMed1978

[Hemangioblastoma of the cauda equina--a case report (author's transl)].

We reported the case of a 40-year-old man who was hospitalized to our department on November 16, 1975 with a year history of neuralgia in the saddle region and vesicorectal dysfunction. Examination of CSF on lumbar puncture at L4-5 revealed xanthochromia with a protein content of 2,560 mg/dl. Myelography revealed a tortuous filling defect at the level of L2 coupled with complete blockade at L3 level. Selective spinal angiography of the left 12th intercostal artery demonstrated the enlarged Adamkiewicz's artery. This blood vessel was found to enter a diffuse uniform density, where no distinct blood vessels were visible. Within one second after the injection of contrast agent an efferent vein appeared from the right side of the density, ascended to the level of Th12 and then, upon turning, descended to the pelvic canal. These findings suggested a hemangioblastoma of the spinal cord. Laminectomy was performed at levels of L2 through L4 and a hemangioblastoma of the cauda equina was totally excised at L3 level. Although the postoperative course was complicated by a transient dysuria and hypesthesia at S1-S5 levels, complete cure was achieved in a month. In the present paper clinical features and neuroradiological examination of a hemangioblastoma of the spinal cord were described.

Adult↗
PubMed1978

[Spontaneous regression of sinus pericranii--report of a case (author's transl)].

Spontaneous regression of sinus pericranii has not been reported in the literatures. The aurthors presented a very rare case of sinus pericranii, which was diagnosed as early as nine days after birth and completely disappeared in seven years. The patient was a nine-day-old boy from normal delivery in full term, who had a soft tumor simulating cephalhematoma in the right parietal region. The overlying scalp looked like a hemangioma bitemporally connecting with strikingly dilated scalp veins. Soft X-ray examination of the skull revealed a homogenous mass and a small bone defect beneath the mass. Venous blood was punctured from the tumor. By means of direct injection of contrast media into the tumor, the superior sagittal sinus as well as many extracranial varicositous veins were shown. No intracranial vascular anomaly. In a year the tumor spontaneously declined and in the following seven years it disappeared completely. Pathogenesis of this lesion was discussed with special reference to cephalhematoma and a possibility of spontaneous regression of sinus pericranii was stressed.

Cranial Sinuses↗
PubMed1976

Potential CNS antitumor agents--phenothiazines I: Nitrogen mustard derivatives.

Four phenothiazine derivatives containing the bis(beta-chloroethyl)aminopropyl side chain were prepared and evaluated in the murine L-1210, P-388, and B-16 melanoma intraperitoneal tumor systems. Moderate P-388 activity was observed. An aminoethyl phenothiazine mustard was compared with the aminopropyl analogs and was superior in all test systems. None of the compounds tested against the murine ependymoblastoma brain tumor system was active.

Animals↗
PubMed1976

Echocardiographic recognition of the cardiac mural tumor.

An abnormal echocardiographic signal was detected in the myocardium on the echocardiographic examination of the septum and posterior left ventricular wall in a patient found to have lymphosarcoma which was diffusely infiltrated in the myocardium. This echocardiographic abnormality was well correlated with the autopsy findings. Echocardiography appears to be one of useful methods in diagnosing cardiac mural tumor antemortemly.

Autopsy↗