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Biomedical subjects

T Hirata

Publications and source records attributed to T Hirata.

At least 487 records · Page 27Linked to original sources
PubMed1981

Biotransformation of aloenin, a bitter glucoside constituent of Aloe arborescens, by rats.

Aloenin has been established to be 4-methoxy-6-(2-beta-D-glucopyranosyloxy-4-hydroxy-6-methylphenyl)-2-pyrone; it shows an inhibitory activity for gastric juice secretion. Rats metabolized it to 4-methoxy-6-(2,4-dihydroxy-6-methylphenyl)-2-pyrone, 2,5-dimethyl-7-hydroxychromone and glucose, which were excreted in the feces and the urine. The distribution of the radioactivity originating from 14C-labeled aloenin was studied. The tracer found in the kidney and the liver reached 60% of the amount administered 24 h after feeding and decreased rapidly in the next 24 h.

Animals↗
PubMed1981

Determination of phenylpyruvic acid in urine and serum by high-performance liquid chromatography with fluorescence detection.

A highly sensitive and simple method for the determination of phenylpyruvic acid in urine and serum is described which employs high-performance liquid chromatography with fluorescence detection. Phenylpyruvic acid, after extraction with ethyl acetate, is reacted with 4'-hydrazino-2-stilbazole in aqueous methanol to give the corresponding fluorescent hydrazone which is separated by reversed-phase chromatography on muBondapak Phenyl. The lower limits of detection are 25 and 32 pmol for phenylpyruvic acid in 0.2 ml of urine and serum, respectively. This sensitivity permits the determination of the acid in urine or normal adults and newborn infants.

Adult↗
PubMed1981

Outcome in low-birth-weight infants (750 to 1,500 grams): a report on 164 cases managed at Children's Hospital, San Francisco, California.

A series of 164 infants, weighing 750 to 1,500 grams, managed at Children's Hospital from January 1, 1972, to December 31, 1975, was studied. Of the 164 infants, 62% (102) survived. Obstetric factors associated with decreased survival were lower gestational age, fetal distress in labor, and breech presentation. Neonatal factors associated with decreased survival were lower birth weight, low Apgar scores, severe respiratory distress syndrome, intracranial hemorrhage, seizures, and sepsis. Of the infants who died, 62% did so within the first 48 hours of life, and 90% within the first 12 days of life. Eighty-two infants were followed for 1 year or longer, and 56 were followed for more than 4 years. Among the 82 infants, cerebral palsy occurred in seven, and less serious neurological handicaps developed in seven additional infants. Of the infants followed for 4 years or longer, 82% were neurologically and developmentally normal. Obstetric factors did not correlate with neurological handicaps; neonatal factors that did correlate with severe respiratory distress syndrome and seizures. Bronchopulmonary dysplasia occurred in 6.5% of inborn infants and in 14.2% of infant transfers.

Apgar Score↗
PubMed1981

A case of focal nodular hyperplasia of the liver.

Focal nodular hyperplasia of the liver is a rare benign tumor of unknown etiology. Presented here is a case of focal nodular hyperplasia of the liver in a 19-year-old man with asymptomatic hepatomegaly. Liver scan and selective hepatic angiography revealed a tumor mass, which was indistinguishable from a malignant tumor. At laparotomy a large mass measured 16 X 10 X 4 cm and weighed 480 gm arising from a part of the left hepatic lobe and extending down to the abdominal cavity was found. The gross and microscopic findings established the diagnosis of focal nodular hyperplasia of the liver. The clinical, radiological and pathological findings in the patient are described in detail.

Adult↗
PubMed1981

Indomethacin produces gastric antral ulcers in the refed rat.

Indomethacin produces gastric corpus erosions in the fasted rat and small intestinal ulcers in the conventionally fed rat. We found that in rats fed chow pellets for 1 h after a 24-h fast, indomethacin given within 2 h after refeeding produced lesions in the gastric antrum, primarily along the lesser curvature, and also in the small intestine. The antral lesions reached a maximum size in 6-10 h, penetrated the muscularis mucosae within 3 days, and did not diminish for at least 7 days. The formation of the antral ulcer was prevented by prostaglandins or adrenalectomy, but was not affected by cimetidine, atropine, and/or vagotomy. In contrast, the gastric corpus erosions produced by indomethacin in the fasted rat were prevented by antisecretory drugs or vagotomy, and were aggravated by adrenalectomy. It is concluded that: (a) the chronic antral ulcers produced by indomethacin in a refed rat mimic human gastric ulcer with regard to location and histology; and (b) the mechanism of antral ulcer formation is different from corpus erosion formation, in that it was resistant to antisecretory drugs and vagotomy and was prevented by adrenalectomy. This experimental ulcer model could prove useful for studies of the etiology and therapy of gastric ulcer disease.

Adrenalectomy↗