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T Hilden

Publications and source records attributed to T Hilden.

At least 19 recordsLinked to original sources
PubMed1999

Leukocyte adhesion--a fundamental process in leukocyte physiology.

Leukocyte adhesion is of pivotal functional importance. The adhesion involves several different adhesion molecules, the most important of which are the leukocyte beta 2-integrins (CD11/CD18), the intercellular adhesion molecules, and the selectins. We and others have extensively studied the specificity and binding sites in the integrins and the intercellular adhesion molecules for their receptors and ligands. The integrins have to become activated to exert their functions but the possible mechanisms of activation remain poorly understood. Importantly, a few novel intercellular adhesion molecules have been recently described, which seem to function only in specific tissues. Furthermore, it is becoming increasingly apparent that changes in integrins and intercellular adhesion molecules are associated with a number of acute and chronic diseases.

Cell Adhesion↗
PubMed1992

[On ketamine].

Explore the source record for details and available documents.

Humans↗
PubMed1991

The influence of arterial compliance on diastolic blood pressure and its relation to cardiovascular events.

Reduction of arterial compliance leads to a higher systolic (SBP) and a lower diastolic blood pressure (DBP). The increasing occurrence of reduced arterial compliance is responsible for the steep increase in SBP after the age of 50 years and also for the constancy and later decline in DBP. Reduced arterial compliance will blur the relationship between mean arterial pressure and DBP. This may change the relationships between cardiovascular events and DBP. The possibility of non-causal co-existence of reduced compliance and atherosclerosis is discussed. Such a co-existence would markedly influence the relationship between cardiovascular events and DBP. Finally, the influence that reduced compliance might have on the shape of the relation between cardiovascular episodes and diastolic and systolic blood pressure is discussed.

Arteries↗
PubMed1988

Increased total mortality and decreased functional capacity are associated with low systolic blood pressure among elderly women.

As part of an epidemiological survey of 75-, 80- and 85-year-old citizens of Copenhagen, the blood pressure of 566 participants was measured at home visits. Based on WHO criteria, systolic hypertension was present in 66% of the men and 71% of the women, and diastolic hypertension was demonstrated in 18% of the men and 22% of the women. The systolic blood pressure was significantly higher among women than among men. Surprisingly, the mortality rate was highest among women with low systolic blood pressure. There was no correlation between blood pressure and morbidity, except among men with low systolic blood pressure, the majority of whom suffered from neoplasms. The women with the lowest systolic blood pressure displayed poor functional capacity in four--and the men in one--out of ten partial functions. No correlation could be demonstrated between blood pressure and intake of medicine. In fact, participants receiving antihypertensives had higher systolic and diastolic blood pressures compared with the other participants.

Activities of Daily Living↗
PubMed1986

Severe hypertension with cerebral symptoms treated with furosemide, fractionated diazoxide or dihydralazine. Danish Multicenter Study.

Emergency treatment of acute, severe hypertension defined as diastolic blood pressure (DBP) greater than or equal to 135 mmHg combined with cerebral symptoms was prospectively monitored in a randomized multicenter study including 64 patients. Treatment was divided into two periods. In the first hour the patients were observed in the supine position after being given 40 mg furosemide intravenously. If DBP remained greater than 125 mmHg (n = 52), the patients were put on fractionated diazoxide administered intravenously (n = 28) or dihydralazine administered intramuscularly (n = 24). Blood pressure (BP) decreased with diazoxide from an average of 241/149 mmHg to 180/111 mmHg after 5 hours and with dihydralazine from 237/149 to 161/101 mmHg. The inter-individual BP response varied considerably. A clear and identical regression in neurological symptoms was observed on both drug regimens. No new neurological symptoms were seen to develop. It is concluded that a gradual fall in BP can be obtained after fractionated dosage of diazoxide (i.v.) as well as after dihydralazine (i.m.). The indication of acute parenteral therapy compared to less aggressive oral treatment is discussed.

Adult↗
PubMed1986

Reversibility of cerebral symptoms in severe hypertension in relation to acute antihypertensive therapy. Danish Multicenter Study.

Cerebral symptoms were registered in a multicenter study including 64 patients with severe hypertension, diastolic blood pressure (DBP) greater than or equal to 135 mmHg, and more or less pronounced hypertensive encephalopathy. The symptoms were: headache (70%), dizziness (35%), consciousness disturbances (28%), nausea (27%), paresis (23%), blurred vision (22%), paraesthesia (21%) and vomiting (14%). None had convulsions or coma. Initial treatment was furosemide i.v., and if DBP was greater than or equal to 125 mmHg after one hour, patients were randomized to treatment with either i.v. diazoxide (bolus injections of 75-150 mg) or i.m. dihydralazine (bolus injections of 6-12.5 mg). A gradual fall in blood pressure (BP) was obtained in all three groups. Along with BP reduction a substantial regression of neurological symptoms was registered. After 5 hours only minor cerebral symptoms were present without significant difference between diazoxide and dihydralazine. None developed cerebral complications. The study failed to show a significant correlation between BP reduction and regression of neurological symptoms graded semiquantitatively. Reduction of BP by titration using small repeated bolus injections is recommended, but oral treatment should be considered in the patients who are able to ingest peroral medication in spite of neurological symptoms.

Aged↗