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Biomedical subjects

T Higashi

Publications and source records attributed to T Higashi.

At least 307 records · Page 17Linked to original sources
PubMed1988

Type IV collagen-degrading enzyme activity in human serum.

Type IV collagen-degrading enzyme activity was detected in human serum. Serum was preincubated with 4-aminophenylmercuric acetate and trypsin to activate the enzyme prior to assay. Type IV collagen, purified from human placentas and radiolabeled with [1-14C] acetic anhydride, was used as the substrate. The enzyme activity was measured at pH 7.5 and inhibited by treatment with ethylenediaminetetraacetic acid or heat. The assay of type IV collagen-degrading enzyme in human serum might be useful for estimating the degradation of type IV collagen.

Blood Proteins↗
PubMed1988

[A comparative morphological study of gastric and colorectal cancer--differences in early type IIc and advanced type 4 cancer].

Five hundred and nineteen gastric and 883 colorectal cancers have been compared macroscopically according to their Japanese classification. Most early cancers were found to be of a protruded (I and IIa) type in the intestine and a depressed (IIc) type in the stomach, and it is felt that their histogenesis in the mucosa may play an important role in causing this difference. Type 4 advanced cancer is common in the stomach, but rare in the intestine. Histologically, most type 4 gastric cancers present scirrhous findings. Type 4 colorectal cancers can be classified into 4 groups based on their pathological characteristics, such as lymphangiosis, muconodular, mixed, and scirrhous types.

Aged↗
PubMed1987

Identification of Warthin's tumor with technetium-99m pertechnetate.

Salivary gland imaging with Tc-99m pertechnetate is a useful procedure for evaluating the functional status of salivary glands. The only neoplasms of salivary glands known to consistently concentrate Tc-99m pertechnetate are Warthin's tumor and oncocytoma. In the five cases presented, increased concentration of Tc-99m pertechnetate was seen in these tumors of the parotid glands. This finding was useful for preoperative identification of Warthin's tumor. During this investigation, the concentration of Tc-99m pertechnetate in Warthin's tumor varied by histologic type. Thus, a dynamic study may be helpful in evaluating the accumulation rate of Tc-99m pertechnetate into this tumor type. Because the retention of Tc-99m pertechnetate in tumor following stimulation is useful for the diagnosis of Warthin's tumor, a washout image is of importance in establishing this diagnosis.

Adenolymphoma↗
PubMed1987

[The difference between the mechanism of 67Ga accumulation and 59Fe accumulation in cultured tumor cells].

It is well known that the mechanism of 67Ga accumulation into tumor cells is mediated with transferrin receptor as well as iron. The present study was designed to explore the difference between the mechanism of gallium accumulation and that of iron by using mouse leukemic cell line L5178Y. When monensin which inhibits the recycle of transferrin receptor was added to the incubated system, accumulation of 59Fe and 67Ga was clearly diminished compared with that of control. However, inhibition of 59Fe accumulation was more remarkable than that of 67Ga. Furthermore, monensin has a action of Na+ ionophore which decreases Na+ gradient between the inside and the outside of the plasma membrane. Following administration of monensin, 67Ga accumulation was diminished according to the loss of the Na+ gradient. On the other hand, following administration of valinomycin, 67Ga accumulation was not affected by the loss of the K+ gradient. From these results, it was suggested that the mechanism of 67Ga accumulation into tumor cells differed from that of 59Fe and transferrin receptor and Na+ gradient of tumor cells played an important role on 67Ga accumulation into tumor cells.

Animals↗
PubMed1987

[Collision tumor of the stomach].

In a gastric neoplasm, malignant lymphoma is a relatively rare disease and a malignant lymphoma complicated by a carcinoma is very rarely found in the same stomach. As far as we could determine in a search of the literature, the coexistence of a gastric cancer and a malignant lymphoma was found in only 30 cases including our case and collision was seen in 10 of these. Our report concerns a recent case of malignant gastric lymphoma colliding with II c early gastric cancer, and is followed by a discussion. The patient, a man of 68, had complained of epigastralgia. The case was diagnosed as a gastric malignant lymphoma after an upper gastrointestinal roentgenogram and endoscopy. A biopsy revealed a torous malignant lymphoma (diffuse medium-sized cell type) and an II c early gastric cancer (tub 2) and suggested the collision between them.

Aged↗
PubMed1987

[Peripheral neuroepithelioma in the retroperitoneum; a case report and a review of the literature].

A 30-year-old man with peripheral neuroepithelioma which was present in the retroperitoneum underwent surgical treatment under the diagnosis of germ cell tumor. Subsequently he died of local recurrence and multiple metastases to the liver seven months after surgery. To our knowledge, this is the second case of peripheral neuroepithelioma which was observed in the retroperitoneal space in the literature of the world. We also reviewed 20 cases of peripheral neuroepithelioma reported in Japan.

Adult↗