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Biomedical subjects

T Hermanns-Lê

Publications and source records attributed to T Hermanns-Lê.

11 recordsLinked to original sources
PubMed1995

Surfactant-induced dermatitis: comparison of corneosurfametry with predictive testing on human and reconstructed skin.

BACKGROUND: Surfactants elicit alterations in the stratum corneum. Predictive tests that avoid animal experimentation are needed. OBJECTIVE: This study compares three methods of rating and predicting shampoo-induced irritation. METHODS: Corneosurfametry entails collection of stratum corneum followed by brief contact with diluted surfactants and measurement of variations in staining of samples. RESULTS: Corneosurfametry appears to correlate well with in vivo testing in volunteers with sensitive skin. However, corneosurfametry presents less interindividual variability than in vivo testing and allows better discrimination among mild products. Morphologic information about surfactant-induced loosening of corneocytes may be increased by testing surfactants on human skin equivalent. Results are similar to those provided by specimens used for corneosurfametry. CONCLUSION: The corneosurfametric prediction of surfactant irritancy correlates with in vivo testing and with in vitro evaluation on human skin equivalent.

Adult↗
PubMed1994

Vimentinoma, an unusual neoplasm of the skin.

We report an unusual benign neoplasm that developed in a child. Tumoral cells were filled with vimentin intermediate filaments. No other features of differentiation were found by immunohistochemistry and electron microscopy. 'Vimentinoma' appears to be the most appropriate name for this neoplasm.

Child↗
PubMed1994

[Hashimoto-Pritzker self-healing reticulohistiocytosis and congenital histiocytosis].

BACKGROUND: Congenital histiocytosis is divided into four entities differing in their clinical and histological features and prognosis. Early, accurate diagnosis is essential for treatment. CASE REPORT: Seven cutaneous nodules were seen in a male neonate. One of these nodules was biopsied on the 7th day of life; it showed the typical findings of Hashimoto-Pritzker reticulohistiocytosis by optical and electron microscopy using immunological markers. The nodules spontaneously disappeared after a few months. CONCLUSIONS: Congenital forms of histiocytosis must be accurately characterized. Hashimoto-Pritzker reticulohistiocytosis is a benign and self-healing disease restricted to the skin, while the Letterer-Siwe disease has a completely different course and treatment.

Humans↗
PubMed1993

[Ultrastructural study of azidothymidine-induced melanoderma in an AIDS patient].

We report an ultrastructural study of azidothymidine-induced melanoderma. The hyperpigmentation is linked to the presence of numerous single melanosomes and polymelanosomes in keratinocytes at all levels of the epidermis, and in dermal Factor XIIIa-positive dendrocytes. Such observation suggests an increased melanogenesis in melanocytes associated to a defect in the degradation of melanosomes normally occurring during epidermal maturation.

Acquired Immunodeficiency Syndrome↗
PubMed1992

Restrictive dermopathy, a lethal form of arthrogryposis multiplex with skin and bone dysplasias: three new cases and review of the literature.

Restrictive dermopathy is a rare, lethal autosomal recessive syndrome. We report on 3 unrelated affected stillborn infants of consanguineous parents. Clinical findings include a tight, thin, translucent, taut skin, which tears spontaneously in flexion creases, arthrogryposis multiplex congenita (including the temporomandibular joint), enlarged fontanelles, typical face and dysplasia of clavicles and long bones. Histologic abnormalities include hyperplastic, abnormally keratinized epidermis, reduced tonofilaments, thin, compact dermis with hypoplasia of the elastic fibres, and abnormal subcutaneous fat. Fifteen previous cases are reviewed.

Abnormalities, Multiple↗
PubMed1992

Dermatopathological aspects of restrictive dermopathy.

We present an immunopathological and electronmicroscopic study of the skin of two newborns affected by restrictive dermopathy. Evidence of abnormal maturation was found in the epidermis, cutaneous appendages, dermis, and hypodermis. Our observations confirm two previous descriptions. We emphasize some unreported data concerning the L1 antigen and Factor XIIIa in the skin. The L1 antigen is expressed in the interadnexal epidermis, but not in hair follicles. This is the reverse pattern compared with normal skin. Factor XIIIa is poorly expressed in dermal dendrocytes, which appear rare compared with controls. The multiple defects in maturation found in all cutaneous tissues suggest a qualitative or quantitative aberration in control mechanisms of tissue interactions.

Antigens, Surface↗
PubMed1992

Evidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis.

Ehlers-Danlos (ED) syndrome type VII is characterized by the accumulation of collagen precursors in connective tissues. ED VII A and B are caused by mutations in the genes of alpha 1 and alpha 2 collagen I which result in the disruption of the cleavage site of procollagen I N-proteinase. The existence of ED VII C in humans has been hypothesized on the basis of a disorder in cattle and sheep related to the absence of the enzyme. We now present evidence for the existence of this disease in humans, characterized by skin fragility, altered polymers seen as hieroglyphic pictures with electron microscopy, accumulation of p-N-alpha 1 and p-N-alpha 2 collagen type I in the dermis and absence of processing of the p-N-I polypeptides in fibroblast cultures.

Animals↗
PubMed1990

Chemical warfare casualties and yperite-induced xerodermoid.

Chemical warfare agents have been used in recent conflicts. We present a review of the clinical manifestations of mustard gas casualties and we studied the histological presentation of cutaneous lesions. Four groups of alterations were recognized, namely (a) alterations of keratinocytes, (b) epidermal hyperplasia with or without atypia, (c) alterations of the melanocytic system, and (d) structural changes of the dermis.

Adult↗