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Biomedical subjects

T Hawkins

Publications and source records attributed to T Hawkins.

67 records · Page 4Linked to original sources
PubMed1984

Extrarenal arteriovenous fistula. An unusual complication of percutaneous renal transplant biopsy.

A percutaneous allograft biopsy in a renal transplant recipient with declining function was followed by haemorrhage from the external iliac artery requiring repair of the puncture site. A common iliac arteriogram performed subsequently showed an external iliac arteriovenous fistula. In retrospect, an isotope scan performed at 48 h post-transplant, showed the upper pole of the graft overlying the iliac vessels. To avoid such complications we recommend a careful assessment of the anatomical relationships of the transplant kidney to major blood vessels prior to biopsy.

Adult↗
PubMed1983

Is anaemia during continuous ambulatory peritoneal dialysis really better than during haemodialysis?

The level of anaemia in 22 patients on continuous ambulatory peritoneal dialysis (CAPD) was compared with that in 12 patients maintained on intermittent haemodialysis. Contrary to previous reports, the haematocrit did not differ between these groups, nor did it increase progressively with time in those on CAPD. Total red cell volume (RCV) and plasma volume were also similar in the two groups. Clearance of radioactive iron from plasma (plasma iron turnover) was higher in haemodialysis than in CAPD patients but erythrocyte radioiron utilisation (FeU) did not differ in the two groups. RCV in both CAPD and haemodialysis patients correlated positively with erythrocyte iron turnover and FeU but not with red cell survival, suggesting that the rate of production rather than destruction of red cells is the major determinant of total RCV in dialysis patients. Red cell survival was slightly but significantly higher in CAPD than in haemodialysis patients and increased with time on dialysis, but this difference was insufficient to increase total RCV in CAPD patients above that in haemodialysis patients.

Anemia↗
PubMed1983

Role of lung scanning in assessing the resectability of bronchial carcinoma.

Ventilation and perfusion lung scans were performed in 58 patients before operation for bronchial carcinoma to determine in which patients the lung scan was most useful for assessing mediastinal spread and resectability of the tumour. Perfusion of the affected lung was less with larger and more centrally situated tumours. Perfusion was also less for left-sided than for right-sided tumours but this is explained by the normal differential perfusion of the right and left lungs. The lung scan was unhelpful in predicting resectability of peripheral tumours, but with central tumours if perfusion of the affected lung was less than 25% of the total perfusion the lesion was likely to be non-resectable because of spread to the mediastinum. Airways obstruction was present in 67% of the patients but did not interfere with the interpretation of the scans. In most cases ventilation scans provided no additional information, and the use of krypton-81 m as a sensitive indicator of regional ventilation did not improve on the predictive value of the perfusion scan.

Carcinoma, Bronchogenic↗
PubMed1980

A study of the effects of atenolol and propranolol on renal function in patients with essential hypertension.

1 The effects of propranolol and atenolol given in random order in a cross-over study to fifteen patients with essential hypertension have been studied. 2 Both drugs were effective in lowering blood pressure and side effects were not markedly different. 3 There was no change in exchangeable sodium or potassium or in total body potassium during treatment with either drug. 4 Ambulant plasma renin activity was reduced by both drugs but the fall in blood pressure was not related to initial plasma renin. 5 Despite equal mean reduction in blood pressure with the two drugs, creatinine clearance fell significantly only during treatment with propranolol. 6 These observations suggest that intra-renal beta 2-adrenoceptors may be of importance in the regulation of renal function.

Adult↗
PubMed1977

The effect of frusemide used for post-prostatectomy irrigation on total body potassium.

The effects of 2 techniques of bladder irrigation on total body potassium have been compared. The results show that a net decrease was associated with both methods. This was marginally greater (0.1 greater than P greater than 0.05) in the group which underwent a forced diuresis using frusemide with a fluid load. This group received some potassium supplements without which it is possible that the decrease would have been greater. It is concluded that this regime cannot be overtly criticised for its potential loss of potassium.

Aged↗
PubMed1975

Immunochemical properties of the membrane-bound D-lactate dehydrogenase from Escherichia coli.

The preparation, characterization, and purification of antibody against the membrane-bound D-lactate dehydrogenase solubilized and purified from Escherichia coli ML 308-225 are described. The antibody is highly specific for the flavin-linked D-lactate dehydrogenase, and incubation of the enzyme with antiserum results in marked inhibition of enzymatic activity. By means of a radioimmune assay, it is demonstrated that membrane vesicles prepared from E. coli ML 308-225dld-3 contain catalytically inactive material which cross-reacts with native D-lactate dehydrogenase. In the following paper, the effects of this antiserum on D-lactate dehydrogenase activity and D-lactate-dependent active transport in native and reconstituted membrane vesicles are examined.

Animals↗