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Biomedical subjects

T Hata

Publications and source records attributed to T Hata.

At least 469 records · Page 26Linked to original sources
PubMed1988

Ultrasonographic measurements of the fetal neck correlated with gestational age.

Ultrasonographic examinations were performed on 121 normal fetuses between 15 to 40 weeks of gestation to measure the fetal neck. The area (FN-A), circumference (FN-C), anteroposterior diameter (FN-APD) and transverse diameter (FN-TD) of the fetal neck correlated well with the gestational age, respectively. Ultrasonographic measurements of the fetal neck in utero are thus new parameters to evaluate the fetal growth and identify the abnormality of the fetal neck in utero.

Anthropometry↗
PubMed1988

[Potentiation of chemotherapeutic activity by a Chinese herb medicine juzen-taiho-toh].

Antitumor activity of Juzen-Taiho-Toh (JTX) and combination effect of JTX with antitumor agents were studied using murine tumors. In order to determine the antitumor activity of JTX, mice inoculated ip with IMC carcinoma (1 X 10(6) cells/CDF1 mouse), sarcoma-180(1 X 10(6) cells/ICR mouse) or Meth-A fibrosarcoma (1 X 10(6) cells/BALB/c mouse) were treated with JTX (12.5-50 mg/kg/day) ip on day 1 through day 10, and the survival days of mice were examined. Treatment with 25 mg/kg/day produced 38.7% increase of life span against IMC carcinoma. However, no antitumor effect was observed on solid form of these tumors by the daily treatment with JTX. Combination effect of JTX and antitumor agents was also examined. ICR mice inoculated sc with 1 X 10(6) cells of sarcoma-180 on day 0 were treated with JTX (2,000 mg/kg/day) po on day-7 through day 30. In addition, some of these groups received mitomycin C (5 mg/kg), cytoxan (67 mg/kg) or adriamycin (2.5 mg/kg) iv on days 3, 8 and 11, and the size of tumor grown in sc site was measured by a caliper. In combination with JTX, mitomycin C resulted in a significantly greater tumor growth inhibition than could be obtained with mitomycin C alone. Secondly, BALB/c or C57BL/6 mice inoculated sc with 1 X 10(4) cells of Meth-A fibrosarcoma or 1 X 10(5) cells of B16 melanoma on day 0 were treated with JTX (2,000 mg/kg/day) po on day 1 through day 30. Some of these group received ip with mitomycin C (3 mg/kg), adriamycin (2 mg/kg), 5-FU (33 mg/kg) or cytoxan (67 mg/kg) on days 3, 6, 9, 12, 15 and 18. From this result, the group treated with JTX and mitomycin C also showed a higher tumor-growth inhibition. Thus, a combination of a high dose of mitomycin C with JTX was more effective than mitomycin C alone.

Animals↗
PubMed1988

Tris(2,4,6-tribromophenoxy)dichlorophosphorane as a condensing agent: a new type of activation of phosphodiester components in the phosphotriester method.

The title compound (BDCP) was found to be effective for the rapid internucleotidic bond formation in the presence of 3-nitro-1,2,4-triazole (NT). Mechanism of the condensation reaction was elucidated by means of 31P-NMR. It was proved that there was no active species but the desired nucleotide derivatives, phosphorochloridate and phosphorylnitrotriazole, in the reaction mixture. Thus, the side-reaction of excess condensing agent in the conventional phosphotriester method was overcome.

Indicators and Reagents↗
PubMed1988

[Infarct size related to the distribution and site of coronary artery lesions studied by the unfolded map technique using single photon emission computed tomography].

To assess the relative importance of the anatomical characteristics of the coronary artery distribution and the sites of the arterial stenoses in relation to infarct size, 21 patients with old myocardial infarction and angiographically-proven 90% or greater stenoses (AHA classification) of one of the major coronary arteries were studied. The infarct size was evaluated by a new quantitative method, the unfolded map, derived from single photon emission computed tomography (SPECT). Eleven patients had right coronary artery disease (Group RCA: segment 1; five patients and segment 2; six patients). Seven patients who had the large left anterior descending artery (LAD) which was distributed to the inferior portion of the apical area were defined as Small R, and four patients with large RCA as Large R. Ten patients each had a significant stenosis in the LAD (Group LAD: segment 6; six patients and segment 7; four patients). Four patients with significant stenosis proximal to segment 9 were defined as Pre-9, and seven patients with stenosis distal to the segment, as Post-9. Stress T1-201 scintigraphy with SPECT was performed and the unfolded map was obtained with data of the maximal count circumferential profiles in the redistribution image. Infarction was defined as a defect below 55% of the standard value. The necrotic area ratio expressed as percentage of the defect area to the entire map area was calculated and used as the indicator of infarct size. Although there was no significant difference in the necrotic area ratio between segment 1 and 2 lesions. Large R had the significantly larger necrotic area ratios (24.9 +- 4.6%) than did Small R (9.7 +- 4.4%; p less than 0.01). In the Group LAD, there was no significant difference in the necrotic area ratio between segment 6 and 7 lesions, but Pre-9 had the larger ratio (30.4 +- 3.3%) than did Post-9 (15.4 +- 7.7%; p less than 0.01). These data suggest that the factors related to infarct size are either the distribution of the coronary arteries in the apical area in the Group RCA or the sites of the stenotic lesions relative to the branching portion of the first diagonal branch in the Group LAD.

Adult↗
PubMed1988

[Evaluation of female intrapelvic blood vessels and their hemodynamics with real-time two-dimensional Doppler ultrasound].

Real-time two-dimensional and pulsed Doppler ultrasound examinations were performed on 5 healthy Japanese with a history of normal menses and 27 pregnant subjects with regular menstrual cycles and no complications. The objective of the study was to visualize blood flow and record blood flow velocity waveforms from the pelvic vessels. This approach led to an accurate estimation of blood flow in a non-invasive manner. No particular technical skill or training is required. The resistance index of the arcuate artery was high in non-pregnant subjects and in those in early pregnancy. By 15 weeks the index became low and there was little change thereafter. We propose that real-time two-dimensional and pulsed Doppler ultrasound will prove to be good diagnostic tools for the detection of various pathologies encountered in the field of obstetrics and gynecology.

Female↗
PubMed1987

Intracardiac blood flow velocity waveforms in normal fetuses in utero.

Sixty-five continuous-wave Doppler ultrasonographic examinations were performed on 57 normal fetuses at 16 to 40 weeks of gestation. Maximal velocities of transmitral, transtricuspid, transaortic and transpulmonary blood flow velocity waveforms were assessed. Transmitral maximal velocity, transtricuspid maximal velocity, transaortic maximal velocity and transpulmonary maximal velocity correlated well with gestational age. The ratio of transtricuspid maximal velocity/transmitral maximal velocity was at least 1 in 44 of 45 fetuses (97.8%). In the ratio of transpulmonary maximal velocity/transaortic maximal velocity, the characteristic change was not evident. Therefore, continuous-wave Doppler ultrasonographic measurement of fetal intracardiac blood flow velocity waveforms in utero can aid in analyzing the physiologic circulatory hemodynamics.

Blood Flow Velocity↗
PubMed1987

Plasma free fatty acids and protein binding of disopyramide during haemodialysis.

The binding of disopyramide (DSP) to plasma (or serum) proteins was determined using an ultrafiltration technique in three patients undergoing haemodialysis. An increase in the free fraction (FF) of DSP during dialysis occurred together with elevation of the free fatty acid (FFA) level in plasma. The effect of FFA on protein binding in vitro was examined using DSP- and FFA-spiked solutions containing human alpha 1-acid glycoprotein and serum albumin. The FF of DSP rose in proportion to increasing FFA levels, supporting the in vivo observations. The findings suggest that the free concentration of DSP should be routinely monitored, especially in haemodialysis patients.

Adult↗
PubMed1987

Fetal liver measurements by ultrasonography.

A total of 378 measurements of fetal liver size were made from 18 weeks gestation through term. Statistical analysis of the results showed a highly significant correlation between fetal liver measurements and gestational age, biparietal diameter, and fetal femur length (R = 0.93, R = 0.89, R = 0.89, respectively). Ultrasonic measurement of the fetal liver is a reliable indicator of fetal growth in the third trimester, as growth rates of the biparietal diameter and head circumference are blunt. Furthermore, consecutive measurements of fetal liver size enhance the detection of symmetrical, fetal growth, by acquisition of various ultrasonic parameters such as biparietal diameter, fetal femur length, fetal abdominal circumference and so forth.

Embryonic and Fetal Development↗
PubMed1987

Cerebral blood flow in normal and abnormal sleep and dreaming.

Measurements of regional or local cerebral blood flow (CBF) by the xenon-133 inhalation method and stable xenon computerized tomography CBF (CTCBF) method were made during relaxed wakefulness and different stages of REM and non-REM sleep in normal age-matched volunteers, narcoleptics, and sleep apneics. In the awake state, CBF values were reduced in both narcoleptics and sleep apneics in the brainstem and cerebellar regions. During sleep onset, whether REM or stage I-II, CBF values were paradoxically increased in narcoleptics but decreased severely in sleep apneics, while in normal volunteers they became diffusely but more moderately decreased. In REM sleep and dreaming CBF values greatly increased, particularly in right temporo-parietal regions in subjects experiencing both visual and auditory dreaming.

Adult↗
PubMed1987

Renal arterial blood flow velocity waveforms in pregnant women.

Seventy-two continuous-wave Doppler ultrasonographic examinations were performed on nine nonpregnant and 56 normal pregnant women. The range of gestation was 6 to 40 weeks, and the objective was to record the renal arterial blood flow velocity waveform. Acceleration time and systolic per diastolic ratio of renal arterial blood flow velocity waveforms were assessed. Of 72 examinations, 68 recordings were made of the left renal artery (94.4%) and 28 of the right renal artery (38.9%), respectively. There was no correlation between acceleration time and systolic per diastolic ratio and gestational age, respectively, and no correlation between acceleration time and systolic per diastolic ratio, and caliceal diameter of the renal pelvis, respectively. Acceleration times of the left and right renal arteries were 47 +/- 11 and 40 +/- 8 msec in nonpregnant women and 62 +/- 23 and 62 +/- 23 msec in pregnant women, respectively. The left and right systolic per diastolic ratios were 3.1 +/- 0.7 and 2.9 +/- 0.5 in nonpregnant women and 2.8 +/- 0.6 and 2.6 +/- 0.5 in pregnant women, respectively. Therefore these data provide a foundation for the study of hydronephrosis, which may occur in pregnant women.

Blood Flow Velocity↗
PubMed1987

Angiotensin-converting enzyme inhibitors: perhydro-1,4-thiazepin-5-one derivatives.

alpha-[6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxoperhydro -1,4-thiazepin-4-yl]acetic acids (monoester monoacids) and their dicarboxylic acids having the hydrophobic substituents at the 2- or 3-position of the thiazepinone ring were prepared and assayed for angiotensin-converting enzyme (ACE) inhibitory activity. The dicarboxylic acids having the pseudoequatorial amino groups at the 6-position and the pseudoequatorial hydrophobic substituents at the 2- or 3-position of the chair conformation of the thiazepinone ring had potent in vitro inhibitory activity. The monoester monoacids having the hydrophobic substituents at the 2-position suppressed pressor response to angiotensin I for a longer duration than those having the substituents at the 3-position when administered orally. The structure-activity relationship was studied by conformational energy calculations of the thiazepinone ring.

Angiotensin-Converting Enzyme Inhibitors↗