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Biomedical subjects

T Harrison

Publications and source records attributed to T Harrison.

At least 73 records · Page 4Linked to original sources
PubMed1990

Persistence of hepatitis A virus in fulminant hepatitis and after liver transplantation.

A peroxidase-labelled, specific mouse monoclonal antibody to hepatitis A virus (HAV) and an in situ hybridization technique (streptavidin-biotin-horseradish peroxidase reaction) with an HAV-specific cDNA probe (recombinant plasmid pAWHA comprising 1.8 kb of the HAV-specific cDNA, located toward the 3' end of the genome) were used to detect HAV in liver tissues in two patients with fulminant viral hepatitis type A treated by liver transplantation after a protracted (day 40: case 1) and relapsing (day 60: case 2) clinical course. HAV antigens and HAV-specific genomic sequences were detected in the hepatectomy tissues and in serial biopsies of the liver grafts through to final follow-up at 2 months (case 2) or death at 7 months after re-grafting for chronic rejection (case 1). In the fulminant liver parenchyma, numerous degenerating and some surviving hepatocytes were positive and randomly scattered. The immunoperoxidase staining was predominantly cytoplasmic and often granular. The localization of the cDNA probe was predominantly nuclear/perinuclear but was occasionally cytoplasmic. High-titre IgM-anti-HAV antibodies persisted until death (case 1) or resolution (5 months) of an acute hepatitis (case 2), which occurred at 2 months, accompanied by HAV antigen (ELISA), in stool. Intact replicating virus particles must have been present in one or more sites in each case, including extrahepatic locations, with a viraemia as the most likely explanation for subsequent reinfection of the grafts.

Adult↗
PubMed1989

Contralateral acoustic-reflex growth function in a patient with a cerebellar tumor: a case study.

The contralateral acoustic-reflex growth functions (ARGFs) for 500-Hz and 1000-Hz tonal activators were obtained pre- and postsurgery in a patient with a right cerebellar tumor. The acoustic-reflex magnitude was quantified as the change in equivalent air volume at the tympanic membrane during acoustic-reflex contraction. The presurgical ARGFs were shallow in the right ear and steep in the left ear at both activator frequencies. The postsurgical ARGFs were steep, bilaterally, reflecting a return to normal in the right ear. The implications with respect to the use of the ARGF measure in differential diagnosis are discussed.

Carcinoma, Squamous Cell↗
PubMed1989

Osteoma of the tongue.

Osteomas are benign bony neoplasms commonly found in long bones and in the skull and facial bones. Osseous growths within soft tissue structures of the head and neck are rare. Review of the English literature reveals only 31 cases of osteomas within the soft tissues of the tongue and 2 in the buccal mucosa. We report on a patient with a bony hard asymptomatic mass at the base of the tongue, which was found to be an osteoma by biopsy. Complete removal was declined by the patient. There was no progression during a six-month period of follow-up.

Adult↗
PubMed1989

Submucosal hypopharyngeal lipoma.

We present the case of a 58-year-old man with a history of dysphagia, who was found to have a submucosal lipoma of the hypopharynx. The lesion was removed endoscopically, with resolution of the patient's symptoms. Lipomas are benign fatty neoplasms commonly found in the soft tissues of the neck. Although they are rarely seen in the tissues of the upper aerodigestive tract, they must be considered in the differential diagnosis of hypopharyngeal masses that may cause dysphagia.

Deglutition Disorders↗
PubMed1988

A taxonomic revision of the small catarrhine primates from the early Miocene of East Africa.

This paper presents a detailed systematic revision of the small catarrhine primates from the early Miocene of East Africa, recovered from sites in Western Kenya and in Uganda dated at between 22 and 17 m.y. Revised diagnoses and amended hypodigms for each of the species are presented. In addition to the currently identified taxa, Limnopithecus legetet Hopwood, 1933, Dendropithecus macinnesi (Le Gros Clark and Leakey, 1950) and Micropithecus clarki Fleagle and Simons, 1978, two further species are recognized. Limnopithecus evansi (MacInnes, 1943) is resurrected as a valid species, based primarily on previously described material from Songhor, and a new genus, Kalepithecus, is described here for the first time, in order to accommodate distinctive material from Songhor and Koru. The distribution of each species in time and space, and the phylogenetic relationships, are discussed in the light of this taxonomic revision.

Africa, Eastern↗
PubMed1988

Psychogenic vomiting among female Asian migrants to the United Kingdom.

Three female Asian migrants to the United Kingdom presented with vomiting which was not of organic origin. Cultural, dynamic and other factors influenced the adoption of vomiting as a manifestation of distress. Non-organic vomiting should be evaluated in terms of its symbolism, gains, and communicatory function for the individual.

Acculturation↗
PubMed1986

New fossil anthropoids from the middle Miocene of East Africa and their bearing on the origin of the oreopithecidae.

Recent paleontological collections at the middle Miocene locality of Maboko Island in Kenya, dated at 15-16 million years, have yielded numerous new specimens belonging to at least five species of fossil anthropoids. The most common species of ape at the site, a medium-sized primate with a very distinctive dental morphology, clearly represents a previously undescribed taxon. When compared with other Miocene anthropoids from East Africa, it has its closest affinities with the poorly known species Rangwapithecus vancouveringi from the early Miocene locality of Rusinga Island. The species from Maboko Island is described here as belonging to a new genus of fossil anthropoid, to which "Rangwapithecus" vancouveringi is also referred. The new genus has a highly distinctive suite of derived characters of its molars and premolars, which it shares with Oreopithecus bambolii from the late Miocene of Europe. These synapomorphies indicate a close phyletic relationship between the East African species and Oreopithecus and form the basis for the inclusion of these taxa in a single family, the Oreopithecidae Schwalbe, 1915. In many respects, however, the East African forms are more conservative than Oreopithecus, and in a general sense they can be regarded as an intermediate grade between Oreopithecus and the more generalized early Miocene catarrhines, the proconsuloids. There is, therefore, good fossil evidence to indicate that the origins of the Oreopithecidae can be traced back to the early Miocene of Africa.

Animals↗