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Biomedical subjects

T Hardy

Publications and source records attributed to T Hardy.

14 recordsLinked to original sources
PubMed2002

Application of locally available materials for the treatment of organic polluted water.

Several types of water treatment technologies including adsorption are now being used to treat polluted water. In this paper the removal of phenol by adsorption will be discussed. Activated carbons are successfully applied for purification of potable water and the removal of organic pollutants in wastwater. This paper is concerned with a low cost approach to treating waste water that is significant especially for those countries where oil palm is an available agricultural product like Malaysia, Ivory Coast, Nigeria, Thailand, Papua New Guinea. In the coastal region coconut is an available agricultural product and activated carbon prepared using coconut shell is also an economical method of water treatment. The materials used in this study were Commercial Activated Carbon (CAC), prepared from coconut shell and Modified Oil Palm Shell (MOPAS) of 1 to 2 mm diameters. The surface area of CAC and MOPAS was 38.5 m2/g and 38.2 m2/g respectively and the iodine number was determined as 674 and 454 for CAC and MOPAS, respectively. From the study the result shows above 70% removal efficiency for 5 mg/L and 40% removal efficiency for 20 mg/L of phenol solution. The performance efficiency will be discussed based on batch test, following Freundlich adsorption isotherm. The results indicate that CAC exhibits a higher adsorptive capacity (Kf of 0.079) as compared to MOPAS (Kf of 0.048). Hence a better removal efficiency for CAC at lower concentration of phenol. Results from column tests show a better adsorptive capacity for CAC (2.73) as compared to MOPAS (2.48).

Adsorption↗
PubMed2000

The rise and fall of a hospital-sponsored group practice.

Each physician group, network, or management services organization developed as part of an "integration" strategy over the past decade is unique. The current status of each of these entities is based on a variety of factors, including the local health care economy and environment, the sponsoring organization, and the entity's leadership. Much of the current news concerning integration initiatives is negative, and significant operating losses and the disillusionment of the participants have been reported. It is important to study the failures, however, for despite the unique factors impacting each one there are universal lessons to be learned in every case. This article chronicles the causes of one integrated group practice's breakup after five years of operation and the process undertaken to return the physicians to small independent practices.

California↗
PubMed2000

The evolution of hospitalist programs.

In just a few years, hospitalist programs have evolved to a third generation, affording key participants an opportunity to reduce inpatient healthcare costs. Because the method of inpatient payment determines the economic winners and losers in the program, the key participants will benefit from the implementation of a program that includes shared incentives. Even though reduced payments for inpatient services might be offset by reduced variable costs for hospitals and increased office revenues for primary care physicians, a hospitalist program is more likely to achieve sustained success if it is structured so that financial rewards are distributed fairly among the participants.

Contract Services↗
PubMed1996

The open Gamma Knife Center concept.

A freestanding Gamma Knife radiosurgery center has been open for just over 1 year in La Jolla, Calif., USA, located in the grounds of a medium-sized community hospital. The center employs a full-time medical physicist and neurosurgical nurse together with clerical personnel. The neurosurgeons and radiation oncologists are drawn from the entire community and bill their fees separately. Written protocols for each indication to be treated govern patient eligibility and suggested treatment algorithms. Additionally, each patient to be treated is presented in conference, and a treatment strategy (i.e., radiosurgery, craniotomy, conventional radiation therapy) is decided. Twenty new physicians and physicists have begun training to use the Gamma Knife in the first year. Certification must be achieved before a clinician can be physician of record.

California↗
PubMed1993

Abscisic acid is involved in the iron-induced synthesis of maize ferritin.

The ubiquitous iron storage protein ferritin has a highly conserved structure in plants and animals, but a distinct cytological location and a different level of control in response to iron excess. Plant ferritins are plastid-localized and transcriptionally regulated in response to iron, while animal ferritins are found in the cytoplasm and have their expression mainly controlled at the translational level. In order to understand the basis of these differences, we developed hydroponic cultures of maize plantlets which allowed an increase in the intracellular iron concentration, leading to a transient accumulation of ferritin mRNA and protein (Lobréaux,S., Massenet,O. and Briat,J.F., 1992, Plant Mol. Biol., 19, 563-575). Here, it is shown that iron induces ferritin and RAB (Responsive to Abscisic Acid) mRNA accumulation relatively with abscisic acid (ABA) accumulation. Ferritin mRNA also accumulates in response to exogenous ABA. Synergistic experiments demonstrate that the ABA and iron responses are linked, although full expression of the ferritin genes cannot be entirely explained by an increase in ABA concentration. Inducibility of ferritin mRNA accumulation by iron is dramatically decreased in the maize ABA-deficient mutant vp2 and can be rescued by addition of exogenous ABA, confirming the involvement of ABA in the iron response in plants. Therefore, it is concluded that a major part of the iron-induced biosynthesis of ferritin is achieved through a pathway involving an increase in the level of the plant hormone ABA. The general conclusion of this work is that the synthesis of the same protein in response to the same environmental signal can be controlled by separate and distinct mechanisms in plants and animals.

Abscisic Acid↗
PubMed1980

The ultrastructural histochemistry and stereoscanning electron microscopy of the rodent and amphibian surfactant systems.

Ultrastructural histochemical precedures were employed to determine the carbohydrate components and their contributions to the rodent and amphibian surfactant systems. Zirconium stained the rodent (rat) cytoplasm surrounding the multilamellar bodies, the Golgi, and was associated with the membrane structures of the compact lamellae of alveolar multilamellar bodies. In the rodent and amphibian (Rana pipiens), ruthenium red stain was observed within all tubular myelin surfactant matricies. The "gutters," tubular myelin surfactant matrix, and intratubular myelin surfactant matrix materials all demonstrated a positive reaction product. The periodic acid-chromic acid-silver procedure revealed irregular channels extending from the multilamellar bodies to the surface of the rodent great alveolar pneumocyte. The extra-pulmonary and respiratory surfaces in both species were additionally studied by stereoscanning electron microscopy. The respiratory anatomy of the rodent was corroborated. The amphibian lung demonstrated three orders of septa, and in the expired state, tertiary septal pits. The amphibian primary septa were hollow, blind tubules containing respiratory surfaces.

Animals↗
PubMed1977

Chemotherapy of malignant mesothelioma.

Twenty-three patients with malignant mesothelioma are described as to mode of presentation, symptoms, method of diagnosis and histology, Beginning in 1972, 10 patients were treated with drug combination including Adriamycin, Dacarbazine (DTIC), Cytoxan, and vincristine. Median survival of these patients was 9.5 months. Twelve patients who were treated with other modes of therapy had a median survival of about 4.75 months. One patient died after 22 days in the hospital, for whom a diagnosis was made at autopsy. While historical retrospective controls involving 13 patients are of limited value in assessing the usefulness of a new treatment, the authors feel that combination chemotherapy in 10 patients has shown enough activity to warrant further study. In addition, wide local resection, where possible, probably increases survival.

Adult↗
PubMed1976

Carcinoembryonic antigen in colorectal practice: report of three cases.

CEA, in combination with the time-honored barium enema, sigmoidoscopy, rectal examination with guaiac determinations, and thorough clinical history, is a useful tool for the colorectal surgeon in following the progression of disease in both colorectal carcinoma patients and patients who have certain premalignant conditions. In this high-risk group of patients, CEA determinations as well as colonoscopy are becoming increasingly useful. That tumors on the left side are associated with higher CEA levels than those on the right side, due to vascular invasion or the grades of the tumors, and that often CEA antigenicity and severity of symptoms in ulcerative colitis correlate well, are emphasized. Finally, following total colectomy in five cases of ulcerative colitis, all CEA titers decreased to the normal range and have remained there.

Adult↗
PubMedDate not supplied

Recruit.

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Group Practice↗