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Biomedical subjects

T Harder

Publications and source records attributed to T Harder.

162 records · Page 9Linked to original sources
PubMed1983

[Clinical aspect and noninvasive diagnosis of cardiac myxomas].

The alteration of cardiac function in the presence of intracardiac tumors varies considerably according to their localization, size, and mode of insertion. Various cardiovascular diseases can be mimicked, e.g., primary valve dysfunction, cardiomyopathy, intracardiac shunts. Embolic events are frequent secondary symptoms. However, subtle noninvasive techniques such as M-mode and sector echocardiography, pulsed Doppler echocardiography, digital video subtraction angiography (DVSA), and computed tomography permit a thorough diagnosis of intracardiac tumorous masses without heart catheterization and catheter angiography. In this paper, myxomas within the left atrium (LA) and the right ventricle (RV) are described. Leading symptoms were systemic embolism and mitral stenosis (LA localization), low cardiac output and right to left shunt (RV localization). First suspicion of intracardiac tumor was raised by M-mode and sector echocardiography, whereas the diagnosis of LA myxoma was in one case missed by computed tomography and the RV myxoma was missed by right ventricular catheterization. In that case, only the four-chamber subxiphoidal sector echogram substantiated the diagnosis and explained the hemodynamic constellation of very low pulmonary pressures combined with right to left shunt. By the new technique of DVSA, all three tumors were plainly visualized. Nevertheless, echocardiography proved to be the most reliable technique of detecting intracardiac tumors.

Aged↗
PubMed1982

[CT findings in ileo-caval thrombosis (author's transl)].

Thrombosis of a large vein can be demonstrated by CT. The thrombosed vein has a hypodense lumen, with a somewhat increased diameter which does not opacify after intravenous contrast injection, but which shows a narrow hyperdense margin. Collateral vessels in the pelvic or paravertebral plexus and dilated veins in the abdominal skin are indirect evidence of ileo-caval thrombosis. CT can also demonstrate the cranial extent of a caval thrombosis. Venous thrombosis demonstrated by CT is an important additional finding in the pre-operative examination of the abdomen.

Adolescent↗
PubMed1982

[Coronary artery aneurysms (author's transl)].

Seven saccular coronary artery aneurysms have been demonstrated in the course of 1452 selective coronary artery angiograms. In six patients they were arterio-sclerotic; in one patient the aneurysm must have been congenital or of mycotic-embolic origin. The differential diagnosis between true aneurysms and other causes of vascular dilatation is discussed. Coronary artery aneurysms have a poor prognosis because of the possibility of rupture with resultant cardiac tamponade, or the development of thrombo-embolic myocardial infarction. These aneurysms can only be diagnosed by means of coronary angiography and require appropriate treatment.

Adult↗
PubMed1982

[Malpositions of the heart and the great vessels by CT (author's transl)].

The CT-findings of the most important kinds of malpositions of the heart are described. The differentiation between the venous and arterial heart cavities is possible noninvasively using a rapid bolus injection of contrast medium. If there is a malposition of the heart, uncertain findings of the heart configuration in the plain chest film can be explained by CT. Anomalies of the great vessels are detectable.

Dextrocardia↗
PubMed1981

[Aortic aneurysms and aortic dissection. Computed tomography - angiography - sonography (author's transl)].

Sixty-four aortic aneurysms and four aortic dissections were studied in two planes with respect to thrombosis, calcification, bleeding and intimal tears. The features demonstrated in 13 abdominal aneurysms by plain films, computed tomography and angiography are described, and the sonographic features in seven. Sonography should be used as a screening method when an abdominal aneurysm is suspected. CT is indicated for thoracic aneurysms, unsatisfactory sonography, suspected involvement of visceral arteries, aortic or iliac artery occlusion, or where bleeding, imminent rupture or dissection are suspected. CT and angiography are complementary methods.

Adult↗
PubMed1981

[Diagnostic position of cavography (author's transl)].

Since computerised tomography and sonography are both capable of direct identification of retroperitoneal structures even if their vascularisation is poor, indication for cavography has been reduced. The majority of cavographies performed during the past three years were executed for the purpose of optimal preparation of surgery of a tumour identified via computerised tomography, sonography or arteriography. In a few cases only was the indication for cavography necessary on account of thrombosis or in order to clarify pre-operatively any anomalous structures. Due to the rapid development of the non-invasive techniques it is expected that indication for cavography will be reduced even further in future.

Adenocarcinoma↗
PubMed1980

[Results of radiation therapy in carcinoma of the endometrium (author's transl)].

141 patients with endometrial cancer underwent radiation therapy at the department of radiology, University of Münster, between 1967 and 1979. The concept of the combined surgical and radiation therapy (intracavitary radium and percutaneous high voltage therapy) was adjusted to the stage (FIGO) and to the depth of penetration of invasive growth into the myometrium, this being ascertained by means of the excised tissues. Five-year survival for Stage-I patients amounted to 93.5%, for Stage II to 84.3% (ca. 80% were staged I or II). Radiation therapy of the aortic lymph nodes using monoaxial pendulum irradiation with 18-MV X-rays is discussed in detail, considering also the secondary radiation effects.

Adult↗
PubMed1979

[Craniofacial tomography in tumours of the nasal fossa and the paranasal sinuses (author's transl)].

Craniofacial tomography of 55 patients with tumours of the nasal fossa and the paranasal sinuses were examined retrospectively. Only those tomograms were considered which had been taken before surgical or radiological treatment. The clinical classification of the tumours resulting from the tomographic findings shows, that these are, in most cases, advances tumours, which have already invaded neighbouring regions. Depending on their original site, the tumours will preferably spread in certain directions. In some cases, the opacity is not caused by the tumour itself, but by accompanying inflammations. The tomogram will always show up intra-operatively established tumourous bone destructions. However, the appearance of bony cortex on x-ray film without any clearly defined outline, may represent pseuodefects, especially when the adjacent tumour shadow is very dense or if the bony cortex is not situated approximately perpendicular to the tomographic level.

Humans↗
PubMed1979

[Angiographic findings in cerebral aneurysms (author's transl)].

The angiograms of 140 patients with congenital intracerebral aneurysms were examined, and specific angiographic findings correlated to course and prognosis of the patient. Vascular spasm at or near the aneurysm seen shortly after its rupture seems to be a protective measure against further hemorrhage. Persistance of spasm for over a week, however, is a bad prognostic sign. Decreased blood flow in the aneurysmal cavity itself on initial angiography was frequently accompanied by an increase in recurrent hermorrhage. This was also true for aneurymsm with multiple lobulations. A mass effect with midline shift was seen in 20% of the patients.

Adult↗
PubMed1978

[Tomographic findings in C.S.F. fistulae (author's transl)].

The majority of C.S.F. fistulae are of traumatic origin and in order to avoid the threat of meningitis, they require operative closure. For the demonstration of the fronto-basal defects, multi-dimensional tomograms in various planes have proved very valuable. In 28 patients examined in the Radiological University Clinic (Münster), defects were most common in the cribriform plate. In addition to a break in its contour, one can find displacement of fragments, step formation, opacification of the adjacent nose or sinuses or intracranial air. 88% of defects could be localised in this way. The tomograms were not helpful in two very small fronto-basal fractures.

Adolescent↗
PubMedDate not supplied

Clinical relevance of CagA-specific antibodies related to CagA status of Helicobacter pylori isolates using immunofluorescence test and PCR.

BACKGROUND: The cagA (cytotoxin-associated gene A) protein is found in about 50% of Helicobacter pylori strains; its clinical relevance in gastroduodenal disease is uncertain. PATIENTS AND METHODS: The frequency of IgG antibodies to cagA was studied by using a commercial Western blot assay in sera of 189 patients with endoscopically and histologically confirmed gastroduodenal disease. In addition, 38 H. pylori strains isolated from biopsies were analyzed by immunofluorescence test (IFT) and PCR for detection of cagA protein and cagA gene sequences, respectively. RESULTS: 54.3-60.0% of all patients with gastrointestinal diseases (chronic gastritis, gastric or duodenal ulcer and chronic duodenitis) and 28.6% with a normal mucosa were found to be positive for anti-cagA IgG antibodies. There was no significant difference in anti-cagA IgG seroprevalence between the different clinical entities. CagA-positive (cagA+) H. pylori strains were detected in 44.7% and 50% of the 38 isolates by PCR and IFT, respectively. 22 of 23 patients infected with cagA+ strains had anti-cagA antibodies. Using PCR as a gold standard, the sensitivity and specificity of the cagA IgG Western blot were 100.0% and 35.0%, respectively; the sensitivity and specificity of the cagA IFT were 76.5% and 71.4%, respectively. The incidence of the cagA+ H. pylori strains detected either by PCR or IFT was significantly higher (p < 0.05 and p < 0.01, respectiveLy) in patients with chronic duodenitis, gastric or duodenal ulcer compared to patients with chronic gastritis (66.7%, 80% and 30.4%, respectiveLy). CONCLUSION: In this study the cagA-specific serological status in H. pylori infections as diagnosed by IgG Western blot was of no predictive value for severity of disease. In contrast, the cagA status of H. pylori isolates, diagnosed by IFT or PCR, was a predictive marker for severe disease and, therefore, also of clinical relevance in the assessment of the virulence of the infecting strain.

Adolescent↗