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Biomedical subjects

T Hara

Publications and source records attributed to T Hara.

At least 1,171 records · Page 65Linked to original sources
PubMed1977

[Safety evaluation of KW-1062. III. Investigation of maximum safety dose on subacute toxicity studies in dogs (author's transl)].

In previous subacute toxicity studies by intramuscular administration carried out in Beagle dogs for 30 days, its maximum safety dose was not confirmed because renal tubular disorder was observed slightly at the dose of 25 mg/kg. Therefore subacute intramuscular toxicity studies were carried out again to investigate maximum safety dose using lower doses (4, 10 mg/kg). As the result of studies, the maximum safety dose was considered to be 10 mg/kg because there were no abnormal changes at both doses.

Aminoglycosides↗
PubMed1976

Action of enpiprazole on emotional behavior induced by hypothalamic stimulation in rats and cats.

Action of enpiprazole on emotional behavior elicited by hypothalamic stimulation in rats and cats was investigated and comparisons were made with effects of diazepam. Two behavioral patterns were elicited by stimulation of the postero-medial part of the hypothalamus in rats: a food-carrying response beginning with exploratory movement and an analogue of fear. Enpiprazole frequently changed the food-carrying response into food-taking response and occasionally analogues of fear into food-carrying and /or food-taking responses. Thresholds for these behaviors were also elevated. Diazepam showed the same effects on the thresholds as enpiprazole, having but little effect on the behavioral patterns. In cats, enpiprazole evelvated the thresholds for affective-defensive responses induced by hypothalamic stimulation in 6 of 8 cases, but lowered them in 2 cases. This suggests that enpiprazple has a 'biphasic effect' in the central nervous system. By contrast,diazepam consistently elevated thresholds. Comparing the action of enpiprazole with that of diazepam it can be presumed that the former is a different type of anxiolytic drug than the latter.

Animals↗
PubMed1976

Transabdominal mucosal transection of the esophagus for the treatment of esophageal varices.

Transabdominal mucosal transection of the esophagus was applied to 20 patients with esophageal varices. The operative procedure involves a longitudinal incision of the muscular layers which follows transection and reanastomosis of the denuded mucosa. With the preservation the muscular structure, postoperative complications such as anastomotic leakage, stenosis or regurgitation, have been minimized. The effect of this procedure on the varices proved satisfactory.

Abdominal Muscles↗
PubMed1976

Distribution of rhodopsin and retinochrome in the squid retina.

The cephalopod retina contains two kinds of photopigments, rhodopsin and retinochrome. For many years retinochrome has been thought to be localized in the inner segments of the visual cells, whereas rhodopsin is in the outer segments. However, it is now clear that retinochrome can be extracted also from fragments of outer segments. In the dark-adapted retina of Loligo pealei retinochrome is distributed half-and-half in the inner and outer segments. Todarodes pacificus contains much more retinochrome than Loligo, and it is more abundant in the outer than in the inner segments. The outer segments of Loligo contain retinochrome and metarhodopsin in addition to rhodopsin, whether squids are kept in the dark or in the light. But there is extremely little metarhodopsin (about 3% of rhodopsin) even in light-adapted eyes. The inner segments contain only retinochrome, and much less in the light than in the dark. On the other hand, retinochrome in the outer segments increases markedly during light adaptation. These facts suggest the possibility that some retinochrome moves forward from the inner to the outer segments during light adaptation and there reacts with metarhodopsin to promote regeneration of rhodopsin.

Animals↗
PubMed1976

Effects of catecholamines on the lipolysis of two kinds of fat cells from adult rabbit.

The administration of various catecholamines and adrenocorticotropic hormone to adult rabbit elevated plasma glycerol concentration. These catecholamines also induced the in vitro lipolysis of isolated interscapular fat cells but could not bring about the lipolysis of epididymal ones, while adrenocorticotropic hormone induced the lipolyses of both kinds of fat cells. It may be speculated from these results that catecholamines liberated endogenously in adult rabbit cannot act on all systemic adipose tissues but have lipolytic effects on a part of them.

Adipose Tissue↗