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Biomedical subjects

T Hamada

Publications and source records attributed to T Hamada.

At least 901 records · Page 50Linked to original sources
PubMed1979

Cytomegalovirus isolation from a chimpanzee with acute demyelinating disease after inoculation of multiple sclerosis brain cells.

A strain of cytomegalovirus (CMV) was isolated during the third subcultivation of explants from the left frontal lobe of a chimpanzee that developed paralysis more than 3 years after intracerebral inoculation at birth with brain cell cultures derived from a patient with multiple sclerosis. Another strain of CMV was also isolated from a lymph node culture taken from the same chimp. The isolates, designated MZM-13 and MZM-14, produced a cytopathic effect characteristic for CMV when inoculated into brain, ganglion, or fibroblast cultures of human or simian origin. Infected cells contained characteristic Cowdry A intranuclear as well as intracytoplasmic inclusion bodies, and 100-nm spherical herpes-like virus particles were detected by electron microscopy in the nucleus and cytoplasm of infected cells. Virus was further identified as CMV with convalescent human anti-CMV serum. Complement-fixing antibody to CMV was present at a titer of 1:32 when the acutely ill chimpanzee was sacrificed. No antibody was detected at birth or at 1 or 2 years of age. A newborn chimpanzee inoculated intracerebrally with MZM-13 developed clinically asymptomatic lesions in the central nervous system characterized by acute and chronic inflammation and degeneration of myelin in cranial and spinal nerve roots. Restriction endonuclease analysis of viral deoxyribonucleic acid isolated from these two viruses indicated that MZM-13 and MZM-14 are identical and are closely related to chimpanzee CMV. No similarity in restriction endonuclease fragment patterns was found between MZM virus and the Towne and Clegg strains of human CMV.

Animals↗
PubMed1979

Relation between integrated electromyographic activity and biting force during voluntary isometric contraction in human masticatory muscles.

The relation between integrated electromyographic activity and computed biting force during voluntary isometric contraction was evaluated in the masticatory muscles of healthy subjects. The slopes of the curves relating integrated electromyographic activity to computed biting force in masseter muscles were steeper on the non-preferred chewing side than on the preferred chewing side, and they progressively became steeper during the course of continuous isometric contraction of a given biting force.

Action Potentials↗
PubMed1978

In vitro studies on mechanism for concentrating function of gallbladder.

The mechanism for concentrating function of gallbladder was studied in vitro, turning and attention to changes in the gallbladder bile composition, especially a marked increase of Na+ and a marked decrease of Cl- in the concentrating process of hepatic bile to gallbladder one. The following results were obtained by the present investigations: 1) bile acids present in bile regulate the rate of Na+ and Cl- transport: 2) the epithelial membrane of the gallbladder can be regarded as being a simple semi-permeable membrane.

Animals↗
PubMed1978

The role of saliva in retention of maxillary complete dentures.

In this study maxillary denture retention was influenced by the salivary volume between the denture base and the mucous membrane. An optimum intervening salivary volume, at which the greatest retention was developed, was also observed. It was observed from determination of electric resistance of palatal mucous membrane that inward and outward flow of intervening saliva was greater in the denture with poor retention than in the one with good retention. Moreover, when the salivary volume between the denture base and mucous membrane was optimum the salivary flow under the denture was minimum.

Adult↗
PubMed1978

Eruptions. Possible involvement of carrier contained in cutaneous tissues.

In some types of drug eruptions, a positive blastoid transformation is frequently seen in peripheral lymphocytes when they are stimulated in vitro with the causative drug in the presence of autologous serum. In these cases, a soluble fraction prepared from guinea pig skin can replace the autologous serum in inducing the lymphocyte fransformation, whereas either the mitochondrial or microsomal fraction of guinea pig skin instead of the autologous serum is less effective. Moreover, in fixed drug eruption, the addition of soluble skin material fractionated by gel filtration with Sephadex G-100 (FrD1) is as effective as the autologous sera in inducing lymphocyte transformation. These results suggest that the soluble fraction of skin is related to the pathogenesis of fixed and exanthematic drug eruptions as a carrier substance of drugs.

Adult↗