Experimenting on humans: tough questions for physicians.
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Biomedical subjects
Publications and source records attributed to T Hager.
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From 1978 to 1980 a total of 119 patients with carcinoma of the rectum were treated by abdominoperineal excision at Erlangen University Surgical Clinic. 66 of these patients were examined by CAT scan in a follow-up study. Local recurrence was found in nine patients. A radical second operation was useful in one case only. Our findings show, that only postoperative check-ups by CAT scan can detect new tumor growth at an early state. The prognostic groups used in Erlangen are helpful in defining the intervals for postoperative examinations by CAT scan.
Operative mortality after intestinal resection in 155 patients with Crohn's disease was 8.4%. In 12 of 13 the cause of death was septic complications, most of them related to prolonged pre-operative cortisone medication. Follow-up examination was possible in 90% of all discharges. Five-year recurrence rate was 37.6%. Recurrence was not prevented by long-term drug treatment. Purely macroscopic assessment of the resection margins would have led to excision within diseased gut: for this reason frozen sections are recommended before the anastomosis is made. Primary death-rate in 30 cases of colectomy with primary ileorectostomy was 3%. In three patients the rectum had to be excised, while in one the anastomosis had to be taken down because of recurrence. The failure rate was thus only 11%. If rectoscopy, stepwise biopsy and intra-operative frozen section indicate a normal rectum it is recommended that ileorectostomy be done rather than diversion ileostomy with occlusion of the rectum or even proctocolectomy.
Anal fissures, internal hemorrhoids and perianal thromboses are very common and frequent diseases. Diagnosis is simple even with limited experience in endoscopy. Treatment of the anal fissure consists in slow dilatation with a bougie in cases of acute fissues if the sphincter internus muscle is not highly spastic, in cases of chronic or very painful acute fissures a posterior or lateral sphincterotomy should be performed. Hemorrhoids can be treated with different methods, the optimal conservative treatment is by injection of phenol. In cases of prolapsing hemorrhoids an operation should be performed. Perianal thromboses should be opened by incision. The different methods of treatment are described.
On the basis of satisfactory results with a new magnetic stoma seal in colostomy patients this seal, consisting of a magnetic ring and cap, was used in an experimental study to convert the colonic conduit into a continent reservoir. Complete continence was obtained in all of the 12 animals which survived the operation. All rings were well accepted by the tissue when the procedure was staged by implanting the ring transperitoneally several weeks prior to fashioning of the conduit. Residual urine was low, owing to an ideal energy-balance pattern. Coloureteric reflux was successfully prevented in all cases where a long-tunnel-modification of the Leadbetter-Clarke technique was used. Hyperchloraemic acidosis and deterioration in renal function were not observed. All conduits were infected.
On the basis of satisfactory results with a new magnetic stoma seal in colostomy patients, this seal, consisting of a magnetic ring and cap, was used in an experimental study to convert the colonic conduit into a continent reservoir. The aim of the study, involving 16 dogs, was to find a method of ring implantation that would avoid infection of the ring and yield complete continence in a higher percentage than had been achieved so far in patients. Complete continence was obtained in all animals but there was a 75% incidence of immediate and delayed infection of the magnetic ring when the ring was inserted transcutaneously. In contrast, all rings were well accepted by the tissue when the procedure was staged with the ring being implanted transperitoneally several weeks prior to fashioning of the conduit. The general problems arising from the colonic conduit when used as continent reservoir are known from the results of colocystoplasty, coloprostatoplasty and colourethroplasty, which are reviewed and compared with our observations. Residual urine was low due to an ideal energy-balance pattern. Coloureteric reflux was successfully prevented in all cases operated on by a long-tunnel modification of the Leadbetter-Clarke technique. Hyperchloremic acidosis and renal function deterioration were not observed. All conduits were infected.
At the surgical hospital of the University of Erlangen/Nürnberg a magnetic closure system was developed for colostomies and ileostomies, which can give continence. Since November 1974 113 magnetic systems have been implanted. We have good results in 31% of the patients, less good results in 16%, and bad results in 53%. The authors demonstrate faults in the indication for the operation and faults in the surgical technique which lead to bad results. Avoiding these faults continence in 70% of patients can be achieved. In no case was the magnetic closure system the reason for bad results.
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The Erlangen magnetic ring for colostomy closure was used in 240 patients. Forty-five rings were explanted because of infection, pressure necrosis, parastomal hernia, invagination, prolapse and stenosis. Although continence was obtained in 68% of patients, only 43% of surviving patients are still using the system. Reasons given for not using the cap were pain and weight. Increased use of deep anterior resections and the introduction of irrigation and improved stoma bags have limited the indications for the use of the magnetic ring.
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