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T Hagen

Publications and source records attributed to T Hagen.

70 records · Page 4Linked to original sources
PubMed1995

[Lumbar facet syndrome. Recommendation for staging before and after intra-articular injection treatment].

INTRODUCTION: Lumbar facet joint syndrome is normally based on spondylarthrosis. One of the most common methods of treating it is intra-articular injection of local anaesthetics and cortisone. In this prospective study our goal was to have an objective grading scale to assess the severity of lumbar facet syndrome before and after injection. METHODS: Thirty-two patients were treated by CT-guided intra-articular injections of 0.3 ml bupivacaine and 0.8 ml methylprednisolone. Five different parameters were scored in each patient: (1) finger-ground distance; (2) Schober index (10 cm distance along lumbar spine, difference in cm after flexion of lumbar spine); (3) rotation of lumbar spine; (4) lumbago; (5) pseudoradicular pain. The last two parameters were evaluated by a visual analog score (VAS) with zero for no pain and 10 for worst possible pain. Each parameter was evaluated with one, two or three points. After adding the points, we graded the severity of lumbar facet joint syndrome. RESULTS: Finger-ground distances improved statistically (P<0.05). Schober index and rotation of lumbar spine were not significant. VAS concerning lumbago and pseudoraducular pain were also statistically significant (P<0.001). Thirteen patients remained in the same grade, 18 patients improved by one grade and 1 patient by two grades. DISCUSSION: The grading system presented for assessing lumbar facet joint syndrome is a good parameter to evaluate the severity of the disease and follow-up after injection of local anaesthetics and cortisone. Although they showed no statistical significance, Schober index and rotation of lumbar spine are necessary to evaluate facet syndrome.

Bupivacaine↗
PubMed1994

[Cigar-like oxalate crystals in ethylene glycol poisoning].

Coma with grave metabolic acidosis, increased anion and osmolal gap, oxalate crystals in urine sediment and increased ultrasound density of the renal parenchyma are essential clues to the diagnosis of ethylene glycol poisoning. Envelope-like dihydrate calcium oxalate crystals are usually found in the sediment of these patients. We describe a patient with needle and cigar-shaped monohydrate calcium oxalate crystals in urinary sediment, but no detectable ethylene glycol in blood tests taken upon arrival at hospital 12 hours after ingestion. The patient was treated with alkali and haemodialysis, and recovered without any sequelae. Monohydrate calcium oxalate crystals were an essential clue for diagnosis of ethylene glycol poisoning in this patient.

Adult↗
PubMed1994

Septal myectomy for left ventricular outflow tract obstruction after mitral valve repair.

We describe a patient with a left ventricular outflow tract obstruction after mitral valve repair. Intraoperative transesophageal echocardiography permitted us to recognize the role of a bulging septum in the development of a systolic motion of the mitral valve. A left ventricular septal myectomy and myotomy was able to relieve the left ventricular outflow tract obstruction and the systolic anterior motion of the mitral valve.

Heart Septum↗
PubMed1994

[Information improving secondary evaluation procedures in neuroradiology].

The development of special computer and software systems has exerted great influence on computer-assisted image processing in neuroradiology. In this article we try to give an overview of the present and future applications. The applications can be subdivided into segmentation, image analysis, three-dimensional imaging and image fusion. Segmentation plays an important role, because it is frequently the basis for the other methods. Image analysis, like planimetry, volumetry or the calculation of angles, is already used in clinical applications. In this way the course of diseases can be checked objectively. Three-dimensional imaging is especially useful in the planning of surgical and stereotactic approaches. The results and value of three-dimensional imaging depend on the segmentation technique. Therefore, they are evaluated differently. Image fusion allows the simultaneous presentation of image data of different modalities. In particular, the image fusion of morphological findings and functional parameters is applied in clinical neuroradiology. Our experience with these methods suggests that computer-assisted image processing will be of considerable help in neuroradiology.

Brain↗
PubMed1994

[Neuroradiologic diagnosis of intracranial epidermoid tumors].

Intracranial epidermoids are primarily extracerebral congenital cysts. Intra- and extradural types are differentiated: intradural lesions originate in the intracranial CSF spaces, and extradural lesions in the bony skull. Epidermoids increase in size passively as the result of an increase in the cyst volume and not because of active growth. Clinically epidermoids behave like benign, slow-growing cerebral tumours. Differential diagnosis includes other cysts and cystic tumours. Neuroradiologically epidermoids present as polycystic lesions showing extensive growth in the extracerebral CSF spaces and secondary invagination of the brain. On CT and MR, despite the high cholesterol content, epidermoids show the characteristics of liquor and not those of fat. It can be shown that the typical CT and MR appearance of an epidermoid is due to the different proportions of CSF in the cyst content, which results from diffusion or dehiscence of the cyst capsule. The present study was based on analysis of 6 cases selected from a total of 29 patients with CNS epidermoids.

Adult↗
PubMed1993

Net adenine nucleotide transport in rat kidney mitochondria.

This study investigated the hypothesis that changes in the adenine nucleotide (ATP + ADP + AMP) content of kidney mitochondria can occur by a transport mechanism that catalyzes net transfer of adenine nucleotides across the inner mitochondrial membrane. The adenine nucleotide content of isolated kidney mitochondria was 8.23 +/- 0.85 nmol/mg mitochondrial protein. This amount increased or decreased as a function of the external [ATP-Mg] when mitochondria were incubated in phosphate-containing medium. The increases and decreases were inhibited to different extents by 100 microM EGTA (ethylene glycol bis (beta-aminoethyl ether) N,N'-tetraacetic acid) or 5 microM carboxyatractyloside (CAT), suggesting two transport mechanisms. The unidirectional components (influx and efflux) of net flux were examined separately for the CAT-insensitive (EGTA-sensitive) and CAT-sensitive (EGTA-insensitive) mechanisms. CAT-insensitive adenine nucleotide influx and efflux were stimulated by [Ca2+]free up to 2 microM; for ATP influx, Km was 1.7 mM, Vmax was 3.5 nmol/min/mg protein, and Mg2+ was required. Efflux varied as a function of both the external and matrix [ATP] and was completely inhibited by mersalyl. ATP was a better substrate than ADP, and ADP transport did not require Mg2+. The CAT-sensitive mechanism was characterized by studying phosphate-induced adenine nucleotide efflux. Efflux varied with external [Pi] and with matrix [ATP] and was not inhibited by cyclosporin. The amount of CAT required for maximal inhibition was 800 pmol/mg protein. In contrast to CAT-insensitive efflux, this pathway was only partially inhibited by mersalyl and showed no preference for ATP vs ADP. In conclusion, two distinct mechanisms for net adenine nucleotide transport were demonstrated. Both exchange adenine nucleotides (ATP-Mg or ADP) for Pi. One mechanism is identical to the CAT-insensitive ATP-Mg/Pi carrier known in liver mitochondria; the other is a CAT-sensitive mechanism that is not present in liver and may represent a novel function of the ADP/ATP translocase or another CAT-sensitive carrier.

Adenine Nucleotides↗
PubMed1990

[Charcot-Marie-Tooth disease. Peroneal muscular atrophy].

The classification of Charcot-Marie-Tooth disease is provisional, because the chromosome and gene localization is still not precisely known, and gene products have not been identified. This article presents an analysis of the clinical, genetical and neurophysiological data of eight Charcot-Marie-Tooth patients. The study was carried out to find out if it is possible to classify the disease from neurophysiological and genetical data. We found Charcot-Marie-Tooth disease transmitted autosomal dominant in three cases, whereas no family pattern was apparent in the remaining five. Among the three cases of autosomal dominant transmission, two were of the segmental demyelinization type, and one had axonal neuropathy. The five patients without a distinct family pattern consisted of three with segmental demyelinization and two with axonal neuropathy. Thus, the neurophysiological subdivision did not correlate with the inheritance, which indicates a genetical heterogeneity for the Charcot-Marie-Tooth disease.

Adolescent↗
PubMed1990

Phospholipid specificity of bovine heart bc1 complex.

Bovine heart bc1 complex was reversibly inactivated by a new simple and effective chromatographic delipidation method. Upon phospholipid replenishment, catalytic activity increased from values near zero to values 2-6-times higher than those of the original preparation. Compared to original preparations maximally activated by additional phospholipid, the degree of reactivation was up to 100%. By this delipidation method, the 6.4-kDa protein subunit was removed with the phospholipid. The loss of this protein neither diminished electron transport activity nor abolished proton translocation. Two requirements were necessary to obtain quantitative data: (a) only bc1 complexes, homogeneously dissolved before and after relipidation had to be used and (b) the phospholipid bound to the complex had to be determined. The correlation of catalytic activity to bound phospholipid was studied in the range of low phospholipid/protein ratios, which had previously been insufficiently resolved. Catalytic activity increased linearly with added phospholipid up to a molar ratio of 80-100 lipid molecules/dimeric complex. This corresponds to the number of phospholipid molecules that complete a single bilayer annulus. The activating effect of phospholipid is not merely due to a hydrophobic phase effect, since it strongly depends on the nature of the polar head group of the added phospholipid. Of the three major phospholipids bound to the bc1 complex, only phosphatidylethanolamine and phosphatidylcholine activated when added as sole phospholipid. Tightly bound diphosphatidylglycerol was needed for preservation of the native complex structure.

Animals↗
PubMed1989

Behavioral effects of benzodiazepine antagonists in chlordiazepoxide tolerant and non-tolerant rats.

Rats were trained to respond under 3-min fixed-interval schedules of food presentation, and effects of the benzodiazepine-receptor ligands, flumazenil, 2-(4-methoxy-phenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one (CGS 9895), 3-carbo-t-butoxy-beta-carboline (beta-CCtB), and beta-carboline-3-carboxylic acid ethyl ester (beta-CCE) were assessed before and after the induction of tolerance to chlordiazepoxide. Before daily administration of chlordiazepoxide, none of the antagonists produced appreciable effects on rates of responding up to doses of 32.0 mg/kg i.p. beta-CCE was the only antagonist studied at a higher dose (100.0 mg/kg i.p.), which decreased response rates. After 23 days of daily chlordiazepoxide administration (oral doses started at 10 and increased to 100 mg/kg/day by the 17th day), dose-effect curves for chlordiazepoxide were shifted to the right by about one-half log unit. Subjects were also more sensitive to the flumazenil, CGS 9895, and beta-CCtB, however, since these drugs produced only small effects in non-tolerant subjects, precise estimates of the degree of the shift in dose-effect curves could not be estimated. However, there were differences in the changes in the dose-effect curves induced by chlordiazepoxide tolerance. These results suggest differences in mechanism of action of antagonists in tolerant and non-tolerant subjects, and further that the sensitivity that is induced to antagonists in tolerant subjects is not conferred equally to all drugs having benzodiazepine antagonist activity.

Animals↗
PubMed1984

Biomimetic approach to potential benzodiazepine receptor agonists and antagonists.

Several beta-carbolines, isoquinolines, imidazopyridines , and canthin -6-ones prepared in biomimetic fashion were tested for their ability to bind to the benzodiazepine receptor. Methyl isoquinoline-3-carboxylate, methyl 6,7- dimethoxyisoquinoline -3-carboxylate (3b) 1-phenyl-3- carbomethoxyimidazopyridine , (6B,) and canthin -6- one ( 13a ) bound with moderate affinities, while 2- carbomethoxycanthin -6- one ( 13b ) bound to benzodiazepine receptors with an affinity comparable to several pharmacologically active benzodiazepines. The potency of 13b suggests that the benzodiazepine receptor(s) can tolerate substitution at positions 1 and 9 of a beta-carboline without loss of activity if the substituents are trigonal and maintain a planar topography. Moreover, displacement of the carbonyl group by two atoms from the aromatic ring (C) of the beta-carboline skeleton caused a marked decrease in binding to the benzodiazepine receptor. This observation supports the hypothesis that maximum binding affinity of beta-carbolines is achieved when the carbonyl group at position 3 is attached directly to the aromatic pyridine ring.

Animals↗
PubMed1976

Indomethacin-induced delayed fracture healing.

A patient with an ankle joint fracture-dislocation was preoperatively treated with indomethacin. As in previous animal experiments, indomethacin was found to have an inhibitory effect on bone formation. It is suggested that indomethacin should be used with caution if periosteal fracture healing is anticipated.

Ankle↗
PubMedDate not supplied

Correlation of regional cerebral blood flow measured by stable xenon CT and perfusion MRI.

PURPOSE: The purpose of this work was to investigate the validity of perfusion MRI in comparison with stable xenon CT for evaluating regional cerebral blood flow (rCBF). METHOD: The rCBF was measured by xenon CT and perfusion MRI within a 24 h interval in 10 patients (mean +/- SD age 63 +/- 10 years). For perfusion MRI, absolute values of rCBF were calculated based on the indicator dilution theory after injection of 0.1 mmol/kg of Gd-DTPA. Eight to 10 regions of interest (37 mm2) were located in the white and gray matter on the rCBF images for each of the 10 patients. RESULTS: The mean +/- SD values of rCBF in gray matter were 48.5 +/- 14.1 ml/100 g/min measured by xenon CT and 52.2 +/- 16.4 ml/100 g/min measured by perfusion MRI. In the white matter, the rCBF was 22.6 +/- 9.1 ml/100 g/min by xenon CT and 27.4 +/- 6.8 ml/100 g/min by perfusion MRI. There was a good correlation of rCBF values between perfusion MRI and xenon CT (Pearson correlation coefficient 0.83; p < 0.0001). CONCLUSION: Comparable to xenon CT, perfusion MRI provides relatively high resolution, quantitative local rCBF information coupled to MR anatomy.

Adult↗
PubMedDate not supplied

Replacement of amino acid and protein losses with 1.1% amino acid peritoneal dialysis solution.

OBJECTIVE: Losses of nutrients into dialysate may contribute to malnutrition. Peritoneal dialysis (PD) patients are reported to lose 3-4 g/day of amino acids (AAs) and 4-15 g/day of proteins. The extent to which one exchange with a 1.1% AA dialysis solution (Nutrineal, Baxter, Deerfield, IL, U.S.A.) offsets these losses was investigated in a 3-day inpatient study in 20 PD patients. DESIGN: Simple, open-label, cross-over study on consecutive days in a clinical research unit. On day 1 all patients were given a peritoneal equilibration test (PET). On day 2 they received 1.5% dextrose Dianeal (Baxter) as the first exchange of the day and their usual regimen thereafter. On day 3, the first exchange of the day was the 1.1% AA solution in place of 1.5% Dianeal and the usual PD regimen thereafter. On days 2 and 3 all dialysate effluent was collected and analyzed for AAs and proteins. Patients were maintained on a constant diet. RESULTS: Losses of AAs and total proteins on day 2 were 3.4 +/- 0.9 g and 5.8 +/- 2.4 g, respectively, totaling 9.2 +/- 2.7 g. The net uptake of AAs on day 3 was 17.6 +/- 2.6 g (80 +/- 12% of the 22 g infused). Mean gains of AAs on day 3 exceeded losses of proteins and AAs on day 2, p < 0.001. Losses of total proteins, but not losses of AAs, and the net absorption of AAs from the dialysis solution were correlated directly with peritoneal membrane transport characteristics, obtained from the PET. CONCLUSION: Daily losses of AAs and proteins into dialysate are more than offset by gains of AAs absorbed from one exchange with 1.1% AA-based dialysis solution. Net gains of AAs exceeded losses of proteins and AAs in all patients studied. The difference was relatively constant across a wide range of membrane transport types. Net AA gains were approximately two times the total AA and protein losses.

Adult↗