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Biomedical subjects

T H Weller

Publications and source records attributed to T H Weller.

At least 55 records · Page 3Linked to original sources
PubMed1978

Analysis of antigenic diversity among human cytomegaloviruses by kinetic neutralization tests with high-titered rabbit antisera.

Neutralizing antisera to human cytomegalovirus were produced in rabbits with alkaline-buffered extracts of infected cell cultures. The antibody activity was complement dependent and associated primarily with the 7S immunoglobulin fraction. Antisera with homologous K values greater than 10.00 were shown to be suitable for neutralization kinetic studies and were so used to examine the antigenic relatedness of strains AD169, Davis, Esp, C-87, Kerr, and Towne. Based upon the degree of relationship as determined by normalized K values, antisera to the Davis or AD169 strains discriminated three antigenic groups, and an antiserum to strain Esp discriminated two groups.

Animals↗
PubMed1978

Neutralization kinetic studies with genital cytomegalovirus isolates, an antigenically variable group.

Antisera were prepared in rabbits against four low-passage genital isolates, and against two established strains of human cytomegalovirus. With these sera, and seven strains of virus, 42 virus-antisera combinations were examined by kinetic neutralization procedures, and NK-values derived. No evidence accrued indicating that the five genital isolates constituted an antigenically distinct group. The findings support the view that the human cytomegaloviruses are antigenically heterogeneous, with different strains reflecting an antigenic mosaic, the elements of which are present in varying amounts.

Adult↗
PubMed1977

Cervical excretion cytomegalovirus: correlation with secretory and humoral antibody.

Cytomegalovirus (CMV) was isolated from cervical secretions of 10 of 121 outpatients at a venereal disease clinic. The buoyant densities of the DNA of five of the 10 CMV isolates were determined and found to be the same as those reported for strains isolated from other anatomical sites. Nine of 102 specimens of cervical secretions were reactive for IgG antibody to CMV, and five of 61 specimens tested were reactive for secretory IgA antibody, whereas two excretors had only IgG and secretory IgA antibody, whereas two excretors had only IgG antibody. Antibody to early antigen was identified in the sera of excretors whose cervical secretions were reactive for IgG and secretory IgA antibody.

Antibodies, Viral↗
PubMed1975

Schistosomiasis: its significance in a changing human ecology.

Schistosomiasis is a man-made disease. Evaluation of the current status of schistosomiasis requires knowledge of the intensity of infection, a measure now dependent on quantitative egg counts and applied to data only on a limited scale. The determinants of intensity of infection are as yet ill-defined. Morbidity and mortality associated with schistosomiasis are difficult to assess in indigenous populations saddled with a multiplicity of diseases. However, the problem of schistosomiasis and its deleterious consequences will rapidly worsen as an expanding population creates new aquatic habitats favorable for the snail intermediate hosts and as people have increased contact with infected water. Moreover, the number of children is increasing fastest in the developing regions of the world. Children and young adolescents are the age groups primarily responsible for the transmission of schistosomiasis. We are in an era when a predominantly young population will increasingly contaminate a finite environment.

Ecology↗