Biomedical subjects
Publications and source records attributed to T H Falke.
The case of a patient with iron deposition disease is presented to illustrate the value of magnetic resonance imaging (MRI) in the evaluation of this entity. The image characteristics of MRI are discussed and the results are compared with those of computer tomography (CT). The importance of a decrease in T2 relaxation time as the determinant parameter for signal intensity in MRI of the liver in such patients is emphasized.
9 healthy volunteers were examined by magnetic resonance imaging in order to describe the anatomy of the normal female genital tract as seen by this technique. The visualization of the bony and pelvic skeleton and the muscles surrounding these structures is excellent. Due to high contrast resolution relatively small structures like the femoral blood vessels can be positively identified. Imaging of the small bowel is disappointing. Visualization of the rectum and sigmoid colon is relatively good. In the uterine wall three distinct layers can be identified. An interpretation of the origin of these layers based on comparison with macroscopic and microscopic examination of sections of uterine tissue is given. Further research is needed to demonstrate possible cyclic changes in the appearance of the uterus. The ovaries could not be identified with certainty.
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A survey is provided of the first clinical results of NMR scanning with an experimental 0.14-Tesla resistive magnet system at Philips Medical Systems at Eindhoven. Between 1981 and 1983, 173 NMR examinations were performed on 43 healthy volunteers and 130 patients. The patients had a large variety of abnormalities, making statistical analysis invalid. Therefore this presentation is limited to a description of the different aspects of NMR imaging. The advantages and disadvantages of NMR scanning are discussed.
The authors present a case of a massive extrahepatic bile collection diagnosed by Computerized Tomography (CT). The appearance could not be differentiated from a subcapsular haematoma or hepatic cyst. Percutaneous aspiration not only confirmed the diagnosis but also cured the patient. Previous ultrasound examination had been misinterpreted as normal due to omission of A scale review.
A case of Whipple disease demonstrated on computed tomography (CT) a large mesenteric mass of low density and thickened folds in the jejunum, which was confirmed by barium studies. Retroperitoneal manifestations were absent. The importance of CT in demonstrating the extraintestinal manifestations of Whipple disease is emphasized.
The interference of Transurethral Resection (TUR) with CT staging of bladder cancer is discussed in reaction to a recent publication.
A survey is provided of the CT appearance of the normal and postoperative stomach based on a retrospective study on 262 patients. The results were compared with those of conventional barium meal examination. Detailed understanding of the CT anatomy of the normal and postoperative stomach, as well as familiarity with the usual pitfalls, are imperative to guarantee correct interpretation of pathology.
A survey is provided of the CT appearance of the pathological stomach based on a retrospective study on 262 patients. The CT appearance of gastric tumours, pancreatic pathology involving the stomach, oesophago-cardiac varices, ulcers, duodenal pathology is described. The results were compared with those of conventional barium meal examination. The possibilities and limitations of CT in the radiodiagnosis of the stomach are discussed.
The method of graphic reconstruction using the oblique view technique was applied on the transverse CT scans of the vertebral column. In the scanning procedure the low-dose thin-slice technique was used. The method proved valuable for the construction of three-dimensional models as reliable reproduction of the original. The results are useful for preoperative evaluation of the deformed spine as well as for anatomic research.
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A survey of computed tomographic (CT) findings in adrenal pathology is given based on a series of 50 patients examined over a period of 18 months. CT is an accurate non-invasive method of adrenal imaging and is the method of choice as primary radiological investigation in patients suspected of having adrenal disease or recurrent adrenal tumor.
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Candida vertebral osteomyelitis was diagnosed in a patient with systemic lupus erythematodes following X-ray evidence of osteomyelitis and the repeated culturing of Candida albicans from material obtained by needle biopsies from the third lumbar vertebra. The patient had been on glucocorticosteroids and parenteral nutrition six months previously. At that time, a yeast was cultured from the blood and the tip of the subclavian catheter which had been removed. After candida vertebral osteomyelitis was diagnosed, she was treated with ketoconazole for seven months. Recovery was impressive, as judged by the clinical and radiographic findings. At the time of writing this paper--12 months after the withdrawal of ketoconazole--the patient showed no signs of recurrence.
A case is presented of an adult male patient with a heavily calcified multilocular renal cyst (Permann's tumor), transposition of the inferior vena cava and reversed rotation (malrotation) of the bowel. Because of the synchronous embryological development of the forementioned structures, a possible congenital etiology of the multilocular renal cyst is suggested.
The purpose of this study was to evaluate the role of magnetic resonance (MR) imaging in adrenal disease based on correlative imaging with CT. Fifty lesions in 36 patients with a variety of adrenal diseases were evaluated, at 0.5 T using spin echo (SE) multislice short repetition time (TR) and SE multislice multiecho long TR sequences. It is concluded that MR is capable of identifying most adrenal abnormalities previously detected by CT. The results suggest that MR has a greater specificity for mass lesions and might be useful to differentiate nonfunctioning adenomas from functioning adenomas, metastasis, pheochromocytomas, cysts, and intraadrenal hemorrhage. Magnetic resonance imaging also has the potential to detect aldosteronomas by increased signal intensity in addition to contour distortion using long TR/echo time sequences. The ability to perform multiplanar imaging and the presence of superior contrast as compared with CT are useful for the assessment of origin and extension of large lesions and the detection of pheochromocytomas in complex cases. Considering MR's limitations, we believe that at present its major role in evaluation of adrenal disease should be complementary to CT.
The use of CT in the documentation of ancient Egyptian mummified human remains has previously been described in this and other journals. We recently applied this technique to a collection of ancient Egyptian mummified fauna and sarcophagi. We selected an example to illustrate that CT is also uniquely suitable for the study of such specimens in a noninvasive way.
A case of magnetic resonance imaging of adrenocortical carcinoma extending into the inferior vena cava is presented. Magnetic resonance was able to outline the intraluminal extent of tumor thrombus accurately. Signal intensity ratios (mean 0.98 +/- 0.02) of tumor thrombus/primary tumor on T1- and T2-weighted sequences were useful for tissue characterization of tumor thrombus. Time course of the signal intensity of thrombus before and after intravenous administration of 0.1 mmol/kg gadolinium-diethylenetriamine pentaacetic acid was identical to the primary tumor which aided in differentiation from nontumor thrombus.