[Acupuncture analgesia following bilateral adrenalectomy and cervical sympathectomy in rabbits].
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Acupuncture Therapy↗
Biomedical subjects
T H Chu
Publications and source records attributed to T H Chu.
Fetal alcohol syndrome: report of one case.
A male premature baby, whose mother was an alcoholic, was diagnosed as a case of fetal alcohol syndrome according to the following: (1) early-onset intrauterine growth retardation and persistent postnatal growth failure; (2) psychomotor retardation; (3) craniofacial dysmorphism; (4) tetralogy of Fallot; and (5) radioulnar synostosis. The literatures on the clinical manifestation, pathogenesis, and outcome of fetal alcohol syndrome are reviewed.
Fetal Alcohol Spectrum Disorders↗
Cerebral gigantism: report of one case.
One case with the chief complaint of large head was diagnosed as cerebral gigantism (Sotos syndrome) according to the clinical picture and brain computerized tomography. This case, a one-year-old female infant, experienced rapid growth. Her height and head girth were excessive. Some degree of psychomotor retardation was present. Physical features included macrocrania, dolichocephaly, frontal bossing, hypertelorism, high-arched palate, large hands and feet. Cerebral ventricles were mildly dilated on brain computerized tomography. The diagnosis lied mainly on clinical characteristics. Diseases need to be differentiated from Sotos syndrome include fragile X syndrome, arrested hydrocephalus, Canavan disease and Alexander's disease.
Diagnosis, Differential↗
Highly efficient eukaryotic gene expression vectors for peptide secretion.
Recently, we constructed a series of highly efficient universal eukaryotic gene expression vectors (Sheay et al., BioTechniques 15:856-862, 1993). Such vectors contain a viral promoter and enhancer followed by the adenovirus tripartite leader sequence, a multiple cloning site for the insertion of the gene of interest and a polyadenylation sequence. To enable expression of peptides to be secreted into the tissue culture medium or to be incorporated into the cell membrane, several modifications have been introduced into such vectors: stop codons in all three reading frames were inserted at the end of the multiple cloning site and a DNA sequence coding for a signal peptide for transport through the endoplasmatic reticulum (ER) was introduced downstream of the adenovirus tripartite leader sequence followed by two unique restriction enzyme recognition sites. A protocol is described that allows fast and easy cloning of peptide-coding regions, i.e., PCR products, for expression and secretion. The transport of a genetically engineered chimeric transmembrane protein connected to this ER leader sequence was as efficient as that of the original protein from which the ER sequence has been derived. These universal vectors can also be used for the easy construction of any chimeric transmembrane or secretion proteins.
Amino Acid Sequence↗