A chemistry set for life.
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Biomedical subjects
Publications and source records attributed to T Gura.
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A multidisciplinary team may have discovered an important new weapon in the battle of the bulge. On page 2379 of this issue, the team reports that a molecule that is needed for fat synthesis in the body may play a key role in appetite signaling in the brain. Moreover, the investigators produced a synthetic inhibitor of this molecule that spurred a dramatic drop in appetite and weight in mice.
Until now, neurobiologists have had little luck in finding the matchmakers of nerve cell connections, called synapses, in the brain. In today's issue of Cell, researchers report that a single protein can apparently trigger synapse formation between brain neurons isolated from mice and grown in culture. If the finding is borne out in living animals, it could provide fresh insights into how the brain is wired during embryonic development and might eventually provide new ways to enhance or at least maintain synapse formation in the brains of patients suffering from neurodegenerative diseases such as Parkinson's or Alzheimer's.
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