Of 92 men with gonococcal urethritis who were treated orally with amoxicillin, 25 (27.1%) had a simultaneous Chlamydia trachomatis infection. At the first visit 25 patients were treated with a single dose of 1 g of amoxicillin plus 1 g of probenecid (group 1); 24 men were treated with 1 g of amoxicillin twice a day for two days (group 2); and 43 men were treated with 0.75 mg of amoxicillin three times a day for seven days (group 3). At the follow-up visit, one patient in each group still had Neisseria gonorrhoeae-positive cultures. C. trachomatis was not isolated again after treatment from men in group 3, but was isolated from 81.8% in groups 1 and 2 combined (P less than 0.05). One (10%) of the ten men in group 3 who were C. trachomatis-positive before treatment developed postgonococcal urethritis, as compared with seven (63.6%) of 11 in groups 1 and 2 combined (P less than 0.05). Thus a multiple-dose amoxicillin regimen may prove to be a useful alternative to the present-day treatment of chlamydial infections of the urogenital tract.

Adult↗

PubMedDate not supplied

Timolol treatment after myocardial infarction in diabetic patients.

In diabetic patients long-term treatment with timolol after myocardial infarction was related to a reduction in overall mortality, total cardiac death, sudden death, and nonfatal reinfarction, compared with patients in a placebo group. The analyses were based on 99 diabetic patients in the Norwegian timolol multicenter study. The dosage of timolol was 10 mg twice daily and the follow-up period was 12-33 mo (mean: 17 mo). When analyzing all randomized patients, there were 14 deaths in the placebo group and 6 deaths in the timolol group, a reduction of 62.8% (P less than 0.05). The number of nonfatal reinfarctions was 10 in the placebo group and 2 in the timolol group, a reduction of 82.7% (P less than 0.05). With regard to inclusion rate, side effects, withdrawals, and timolol-related reduction in mortality and reinfarction, the diabetic patients basically behaved like nondiabetic patients. The data were analyzed retrospectively and should be confirmed by a prospective study. The study also indicates that long-term treatment with timolol may induce slight carbohydrate intolerance.

Adult↗

PubMedDate not supplied

Holographic vibration analysis of the ossicular chain.

The mechanics of movement of the ossicular chain has been investigated on human temporal bone preparations by means of time average holography. The malleus and incus moved like a lever around an axis, which position was somewhat dependent upon frequency. Simulation of contraction of the muscles of the middle ear gave as result a change in the pattern of movement of the ossicular chain. The position of the rotatory axis was changed, and the amplitudes of vibration were reduced. This should be a protecting mechanism.

Autopsy↗

PubMedDate not supplied

Hearing loss resulting from perilymph fistula. A presentation of two cases.

Two cases of perilymph fistula in the oval window are presented. In such cases hearing loss may be severe and vertigo may or may not be present. Early surgical intervention is recommended, but one should not hesitate to explore a suspected ear, even if considerable time has elapsed.

Adult↗

PubMedDate not supplied

A study of the vibration of the basilar membrane in human temporal bone preparations by the use of the Mössbauer effect.

Using the Mössbauer technique, we have studied the vibration of the human basilar membrane and malleus head in the sound frequency range 0.2--9.0 kHz and at a sound pressure of 100 dB at the tympanic membrane. The displacement frequency response curves for the basilar membrane and the malleus head have similar shapes, with a maximum at about 1 kHz. Below and above 1 kHz the curves have a slope of about 10 dB/octave and--100 dB/octave, respectively. In addition, the basilar membrane has a maximum displacement at a frequency dependent distance from the stapes. A simple hydrodynamic model for the cochlea is used to interpret the experimental data. A possible mechanism for the frequency resolution of sound by the ear and noise-induced hearing loss is discussed.

Acoustic Stimulation↗

PubMedDate not supplied

Vibration measurement of the human tympanic membrane--in vivo.

The vibration patterns of the human eardrum in vivo have been recorded by time average electronic speckle pattern interferometry--ESPI. The necessary stability was achieved by shortening the exposure time of each TV frame. The amplitude--and phasedistribution was mapped across the drum by phase-modulation techniques which also could show the vibrations in slow motion. By photoelectric detection of the TV image intensity, amplitudes down to 2 nm could be measured. Preliminary results are presented.

Holography↗