Biomedical subjects

T Graves

Publications and source records attributed to T Graves.

20 records · Page 2Linked to original sources

PubMed1980

Late sequelae of allergic bronchopulmonary aspergillosis.

Seven patients with late sequelae of allergic bronchopulmonary aspergillosis (ABPA) are described. All seven had significant chronic symptoms from asthma. At the time of diagnosis of ABPA all patients had marked irreversible pulmonary function abnormalities; symptoms of chronic bronchitis were present in all. Pulmonary fibrosis was present in six of seven patients. Three patients have died from irreversible lung disease with terminal cardiac failure. Despite the difficulty in establishing an early diagnosis of ABPA, its importance must be emphasized in order to attempt to prevent progression of the disease to severe irreversible and potentially fatal end-stage lung disease.

Adult↗

PubMedDate not supplied

Advances in antineoplastic therapy.

Despite advances in early diagnosis and treatment of cancer, more than a million new cases of cancer will have been diagnosed in 1990, with an estimated 10% mortality within a year of diagnosis. Thus, the search continues for new or improved antineoplastic agents with a wide spectrum of activity and decreased toxicity. The major advances in single-agent antineoplastic drug therapy include the introduction of cisplatin almost 20 years ago and of etoposide (VP-16) in the mid-1980s. However, within the past two years, analogues of existing antineoplastic agents have been purified and marketed. These drugs offer an enhanced therapeutic index when used alone or in combination with other therapies as well as decreased toxicity and, thus, may enhance patient tolerance.

Alkylating Agents↗