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Biomedical subjects

T Goto

Publications and source records attributed to T Goto.

At least 775 records · Page 43Linked to original sources
PubMed1984

Chronic effects of norepinephrine and vasopressin on urinary prostaglandin E and kallikrein excretions in conscious rats.

To assess in vivo functional interactions of vasopressor substances, norepinephrine and vasopressin, with renal prostaglandins and kallikrein-kinin system which are responsible for the vasodepressor mechanism in the kidney, we evaluated chronic effects of norepinephrine (1.8 mg/kg/day ip) and vasopressin (7.2 U/kg/day ip) on urinary prostaglandin E excretion and urinary kallikrein excretion in conscious rats. Both norepinephrine and vasopressin induced a sustained increase in systolic blood pressure. Norepinephrine induced slight but significant increases in urinary prostaglandin E excretion and urinary kallikrein excretion which were sustained for up to 6 days. Vasopressin induced a marked increase in urinary prostaglandin E excretion which was sustained for up to 6 days, whereas it induced a sustained decrease in urinary kallikrein excretion. Circulating angiotensin II levels was not changed by norepinephrine, but was decreased by vasopressin. These results indicate that renal prostaglandin E may not correlate with renal kallikrein-kinin and renin-angiotensin system in the responses to norepinephrine and vasopressin, and that vasopressin may be a more potent stimulator of the synthesis or release of renal prostaglandin E.

Angiotensin II↗
PubMed1984

Changes in abutment tooth mobility by wearing parital denture: a continued report.

Follow-up measurements of the abutment tooth mobility were carried out to examine the mobility changes for a long period of 12 to 14 years. The subjects were 6 patients, having 12 abutments and they were wearing mandibular unilateral distal extension partial dentures of the same design. These results were as follows: The tooth mobility of the abutment hadn't increased exclusively by the wearing of the distal extension denture over a 10-year period. Among the 12 abutments, 7 abutments showed nearly the same degree of mobility as the initial level, and the mobility of the other 4 abutments increased slightly. However, one abutment alone was extracted because of severe increased mobility. There was an extremely slight difference in the mobility between both abutments and the mobility of each abutment presented nearly the same amount. Also the tendency in the mobility change indicated a similar pattern. The long-term prognosis of mandibular unilateral distal extension partial denture, of the most common clasp design, presented a favourable state during the 12 to 14 years, judging from the changes in the abutment mobility.

Adult↗
PubMed1984

Sialidase of rat hepatomas: qualitative and quantitative comparison with rat liver sialidase.

The subcellular distribution of sialidase in rat hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene was studied by using sialyllactose as a substrate in the pH range of 4.0-7.0. As found in rat liver, the activity was recovered largely in the mitochondrial/lysosomal fraction with an optimal pH of 4.5 and in the cytosolic fraction with an optimal pH of 6.0, although hepatoma lysosomal (acidic) sialidase was also distributed in the microsomal fraction. The lysosomal and cytosolic sialidases of the hepatoma were indistinguishable from the corresponding enzymes of liver in chromatographic behavior, kinetics and substrate specificity. The levels of lysosomal and cytosolic sialidase activities in liver and hepatomas were then studied in the pellet and supernatant fractions, respectively, obtained by centrifuging the postnuclear supernatant at 105,000g for 1 hr. All the hepatomas tested, one primary and three transplanted, showed higher lysosomal sialidase and lower cytosolic sialidase activities as compared with liver. Quantitative changes similar to those seen in hepatomas were observed in regenerating liver after partial hepatectomy.

Animals↗
PubMed1983

Cultivation of arterial endothelial cells from human umbilical cord.

We have developed a simple method for the isolation of endothelial cells from human umbilical artery. The method provides a sufficient number of cells to be of experimental value. The presence of factor VIII antigen specific for endothelium has been demonstrated by immunofluorescence as well as by the peroxidase-antiperoxidase immune complex method.

Antigens↗