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Biomedical subjects

T Godfraind

Publications and source records attributed to T Godfraind.

At least 217 records · Page 12Linked to original sources
PubMed1975

Inhibition by cinnarizine of heart ionic changes induced by isoprenaline.

Cinnarizine, a specific blocker of Ca entry in depolarized smooth muscles, exerts a protection upon cardiac lesions induced by isoprenaline. Its action has been studied on ionic changes induced in hearts of rats injected with 30 mg/kg isoprenaline subcutaneously. Cinnarizine (20 mg/kg) was administered intraperitoneally 2 hours before isoprenaline. Ionic contents (Na,K,C,Mg) were measured over an observation period of 3 days following drug treatment. Isoprenaline induced changes in the content of the various ions studied. Changes occurring in the atria were reversible. The following observations were made in the apex: Mg, transient increase in the first hour followed by a long-lasting decrease; Ca, progressive increase up to 6 hours followed by a progressive restoration; Na, increase up to 24 hours followed by restoration. These ionic changes were significantly reduced by cinnarizine.

Animals↗
PubMed1974

Sodium-calcium sites in smooth muscle and their accessibility to lanthanum.

1. The Na, K, Ca, and Mg contents were determined in longitudinal smooth muscles of the guinea-pig ileum incubated in various physiological solutions with or without ouabain or in a solution containing LaCl(3) 10 mM instead of CaCl(2).2. The Na and K contents were dependent upon the K concentration of the physiological solution. A decrease in [K](o) below 6 m-mole/l. increased tissue Na.3. A rise in [Na](i) was followed by an increase of total cell Ca preceding a secondary decrease of total Ca, as well as by an increased (45)Ca content occurring even when total Ca was decreased.4. Muscles washed in the lanthanum solution contained less Ca and Na than those incubated in the physiological solution. The Mg content was not significantly modified in the presence of La.5. In the La solution, the (45)Ca diffusion space was not different from the [(14)C]inulin diffusion space, indicating that there was no Ca entry within the cell nor Ca binding at superficial sites. (45)Ca content of preloaded muscles decreased; this decrease was blocked after 30 min washout in the La solution: this arrest lasted a further 45 min.6. The cell Ca fraction displaced by increased [Na](i) originated from a Ca compartment which was not blocked by La.

Animals↗