Search PubMed⌕ Search

Biomedical subjects

T Gledhill

Publications and source records attributed to T Gledhill.

30 records · Page 2Linked to original sources
PubMed1983

Cimetidine or vagotomy? Comparison of the effects of proximal gastric vagotomy, cimetidine and placebo on nocturnal intragastric acidity and acid secretion in patients with cimetidine resistant duodenal ulcer.

Nocturnal pH, acid output and volume of gastric secretion have been measured in a group of patients who were referred for surgery because of a poor clinical response to cimetidine. Patients were studied after no treatment, cimetidine 1 g/day and proximal gastric vagotomy. Although pH and acid output were controlled better with cimetidine than no treatment this was not true for volume of secretion. Vagotomy was significantly better than cimetidine in controlling pH, acid output and volume of gastric secretion. The results suggest that cimetidine non-responders should have a good result from proximal gastric vagotomy, making more radical forms of gastric surgery unnecessary.

Adult↗
PubMed1983

Single nocturnal dose of an H2 receptor antagonist for the treatment of duodenal ulcer.

Twenty four hour intragastric acidity and nocturnal acid output have been measured over five separate 24 hour periods in each of 12 patients with duodenal ulcer receiving either placebo, cimetidine 400 mg bd, cimetidine 300 mg nocte, ranitidine 150 mg bd, or ranitidine 300 mg nocte. In these doses ranitidine was significantly more effective at decreasing intragastric acidity and nocturnal acid output than cimetidine. There was no significant difference between twice daily ranitidine and night time ranitidine or between twice daily cimetidine and night time cimetidine in the reduction of intragastric acidity. Nocturnal acid output was controlled significantly better with ranitidine at night, twice daily dosage of ranitidine, and cimetidine at night, than by the twice daily dosage of cimetidine. It is suggested that a single nocturnal dose of cimetidine or ranitidine should be evaluated in a clinical trial.

Cimetidine↗
PubMed1983

Cimetidine 6 years later: a review.

Over 15 million people have been treated with cimetidine since its introduction 6 years ago. Although the drug was thoroughly investigated before release, through its use more information has become available on the side-effects and the way cimetidine has altered the natural history of peptic ulcer disease. Initially, the drug decreased the number of operations performed for peptic ulcer and we have now developed a clearer understanding of the indications for surgery. This review puts together old and new data that may be of value to physicians prescribing cimetidine. The development of cimetidine as an agent for treating peptic ulcer, its side-effects and indications for use and the introduction of other H2 antagonists are discussed. Some data are included on why patients do not respond to H2 blockade and how these patients should be managed.

Animals↗
PubMed1983

A controlled study of single dosage cefamandole in the prophylaxis of wound infections in appendectomy.

A series of 102 consecutive patients undergoing appendectomy through an incision in the right iliac fossa entered a prospective randomized trial to compare the effects of a 2 gram intravenous bolus dose of cefamandole with a control study. No differences occurred in the incidence of wound infection in the two groups. We conclude that there is no place for a single preoperative dosage of cefamandole in the management of appendicitis.

Adult↗
PubMed1979

Arteriovenous malformations of the intestine.

Arteriovenous malforamtions of the intestine are recognized as an uncommon cause of chronic gastrointestinal bleeding. In previous reports, the role of selective mesenteric angiography in the localization of the lesion has been emphasized; with confirmation by in vitro injection of radioopaque dye into the resected specimen. The histologic appearances of arteriovenous malformations are well recognized, although terminology is still confused. In this report, two distinct entities of small vessel malformation are described and the terms submucosal endothelial angiodysplasia and submucosal fibromuscular angiodysplasia are offered.

Aged↗
PubMedDate not supplied

Systems of the future needed today.

Finding the right software for groups requires investigating a practice's quantifiable and qualitative needs, determining goals and translating the needs into system requirements. Software packages don't generally fill all the needs of a practice, therefore it is important to identify vendors who know about health care management and are willing to work with the practice to maintain an edge in business. Look for vendors who continually upgrade their products, service the practice's needs and anticipate future requirements. Quantifiable needs may include tracking patients and patient visits, referring physicians and payers, as well as billing. Qualitative needs include lifestyle (how many hours or days the practice will be open, covering physicians access) and computer usage patterns. Translating the needs into system requirements involves close work with the vendor to customize the software in order to fulfill practice information demands.

Ambulatory Care Information Systems↗