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T Gillespy

Publications and source records attributed to T Gillespy.

44 records · Page 3Linked to original sources

Magnetic resonance imaging of internal derangement of the temporomandibular joint.

MRI is currently capable of diagnosing anterior derangements of the temporomandibular joint. Although large prospective studies comparing MRI with conventional modalities have not yet been done, early evidence suggests that findings seen on high-resolution surface coil MR images correlate very well with CT, arthrographic, and surgical findings. Much additional work will need to be performed before MRI of the temporomandibular joint becomes a standard diagnostic tool. However, we believe strongly that it will begin to replace arthrography and CT for diagnosing internal derangements within the next few years.

Arthrography↗

Magnetic resonance imaging of osteonecrosis.

Because the available preliminary data strongly indicate that MRI is accurate in diagnosing osteonecrosis, MRI of the hips is recommended in patients suspected of having osteonecrosis, especially if other diagnostic studies are equivocal. MRI also may be useful in following patients who have strong risk factors for osteonecrosis, such as corticosteroid therapy, femoral neck fracture, traumatic femoral head dislocation (Fig. 13), slipped capital femoral epiphysis (Fig. 14), and congenital hip dislocation. In diseases such as systemic lupus erythematosus, both hips eventually may become involved in 50 to 80 per cent of cases. Therefore, the unaffected hip of patients with systemic lupus erythematosus and unilateral nontraumatic osteonecrosis of the hip should be monitored regularly with MRI. The hope is that early diagnosis and treatment of femoral head osteonecrosis will prevent the relentless progression to subchondral collapse and disabling arthropathy. MRI also may be useful in staging patients known to have osteonecrosis. The ability of MRI to image directly in multiple planes facilitates the determination of the volume and location of infarcted segments of bone. This information is important in planning any of the surgical procedures used relatively early in the disease, such as core decompression, rotational osteotomy, or bone graft. Moreover, MRI may prove helpful in evaluating the effectiveness of any therapeutic intervention.

Adrenal Cortex Hormones↗

Magnetic resonance imaging of musculoskeletal neoplasms.

MRI has been shown to be very useful in the work-up of musculoskeletal neoplasms. The lack of ionizing radiation, the superb contrast resolution, and the ability to directly scan the sagittal and coronal planes make MRI a very attractive imaging mode for treatment planning. With spin-echo MRI, maximum contrast between tumor and fatty tissues generally occurs with short TR and TE times (T1-weighted images). Likewise, maximum contrast between tumor and muscle, tendon, or ligaments occurs with long values of TR and TE (T2-weighted images). Early experience suggests that the already exceptional contrast resolution seen with MRI can be improved even more with the administration of intravenous contrast agents. Just as with CT, fatty tumors can usually be easily distinguished from other tissue types with MRI by means of their differential intensity behavior at different pulse sequences. Fluid-filled tumors, such as unicameral bone cysts or aneurysmal bone cysts may be suspected in the same manner, especially if a fluid-fluid level is seen within the lesion. Otherwise, MRI has not been useful so far in noninvasively determining the histologic type of tumors. Our experience and that of others suggests that MRI is equal or superior to CT in the work-up of musculoskeletal neoplasms. This is especially striking when it is remembered that one is comparing an immature MRI technology with a mature CT technology. Although CT presently has a central role in the staging of musculoskeletal tumors, MRI will shortly supplant it in many cases.

Adult↗

Progressive senile scoliosis: seven cases of increasing spinal curves in elderly patients.

An increasing scoliosis was documented in seven elderly women. The average curve at the most recent examination was 43 degrees (range 26 degrees-78 degrees). Previous films, from 5 to 26 years before, demonstrated an average increase of 2.3 degrees/year (range 1 degree-4.8 degrees/year). There were three lumbar and four thoracolumbar curves. Three curves were to the right and four were to the left. Only one patient had osteoporotic vertebral body crush fractures. The common underlying mechanism in the progression of senile scoliosis appears to be asymmetric loading of the spine which can be caused by a previously established scoliosis, spondylolysis/spondylolisthesis, lumbosacral anomalies, or leg length discrepancy. Subsequently, factors that can cause a curve to increase include degenerative disc disease with lateral disc space narrowing, soft tissue failure, and osteoporosis. Since even minor scoliosis can potentially progress in the older adult, increased monitoring of scoliosis in patients over age 50 years may be warranted.

Aged↗

Theoretical considerations for optimizing intensity differences between primary musculoskeletal tumors and normal tissue with spin-echo magnetic resonance imaging.

In the radiographic assessment of primary musculoskeletal tumors, it is important for therapy planning to accurately define the extent of a tumor. Using a double spin-echo pulse sequence, the T1 and T2 relaxation times and relative hydrogen densities of several neoplastic tissues and of several normal tissues in four patients were measured. Neoplasms measured included one fibrosarcoma, two osteosarcomas, and one giant cell tumor. Normal tissues measured included normal muscle, fat, and bone marrow. Using a mathematical model of the double spin-echo pulse sequence, the intensity difference between each tumor and each normal tissue for multiple values of TR and TE was calculated. These calculated intensity differences were then used to plot isodifference contour curves for each tissue pair. These plots enabled us to pick combinations of TR and TE that optimized the signal difference between tumor and normal tissue. When comparing tumor with predominantly fatty tissue such as marrow or subcutaneous fat, optimal signal difference in our imager occurred at a TR of 600 to 800 msec and a very short TE. When comparing tumor with muscle, optimal signal difference occurred with very long TR times, and TE times ranging from 30 to 90 msec. These preliminary results suggest that an optimal scanning protocol for primary musculoskeletal tumors should contain at least two different pulse sequences with widely separated TR values (500 and 2000 msec in our instrument), and short to intermediate values of TE (28 and 56 msec in our instrument). It is believed that analysis of isodifference contour plots is a useful method for optimizing intensity differences between any two tissue types.

Bone Neoplasms↗

Magnetic resonance imaging of the hip.

Magnetic resonance imaging of the musculoskeletal system in general and the hip in particular offers many exciting opportunities for innovative and revolutionary diagnostic avenues, the full potential of which awaits further investigative and clinical experience.

Bone Marrow Diseases↗

Magnetic resonance imaging of the musculoskeletal system.

MRI is a complementary technique to CT in the examination of the spine, the hip, and musculoskeletal tumors. In some cases, it provides diagnostic information not available with any other modality, including CT. MRI has the potential to be very useful in the assessment of various marrow-based disorders and may someday obviate the need for contrast-aided studies of ligaments, tendons, and cartilage.

Aged↗

Magnetic resonance imaging in hemophilic arthropathy of the knee.

The MR findings at the examination of 16 knees in 9 hemophilic patients were reviewed. The hemophilic arthropathy was demonstrated in great detail. The state of the joint cartilage, menisci, posterior cruciate ligaments and synovial tissue could be assessed. The presence of intraarticular hemorrhage and cyst fluid in bone cavities was recorded. MRI may become a valuable tool for assessment of early treatment of hemophilic arthropathy.

Adolescent↗