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Biomedical subjects

T Gibson

Publications and source records attributed to T Gibson.

At least 181 records · Page 10Linked to original sources
PubMed1978

Defective phagocytosis by synovial fluid and blood polymorphonuclear leucocytes in patients with rheumatoid arthritis. I. The nature of the defect.

In a series of thirty-seven patients with rheumatoid arthritis (RA), 50% showed a defect of phagocytosis of Candida albicans by synovial fluid polymorphonuclear leucocytes (SF-PMN) and 40% yielded a defect in peripheral blood (PB-PMN). There was a positive correlation between the defective phagocytosis of SF-PMN and PB-PMN suggesting that defective PB-PMN migrate into the synovial fluid. The defect was associated with the lack of a functional C3b receptor on SF-PMN in 64% of patients and on PB-PMN in 40% of patients. SF-PMN or PB-PMN contained intracellular IgG, IgM and C3 in some patients but the presence of these factors could not be correlated with defective phagocytosis of either cell population. There was no correlation between phagocytosis and the differential agglutination test (DAT) ratio of either serum or synovial fluid. The killing of Candida by SF-PMN and BP-PMN was normal. The results could explain the increased susceptibility to joint infection of patients with RA.

Adult↗
PubMed1978

Ketoprofen: double-blind cross-over study with indomethacin administered as a combined suppository/capsule regime in patients with rheumatoid arthritis. A preliminary report.

A double-blind cross-over study is being undertaken in fifty patients with "definite" rheumatoid arthritis, comparing ketoprofen (2-(3-phenylbenzoyl proprionic acid) 75 mg daily orally and 100 mg suppository at night with indomethacin in the same dosage. A pilot study of twenty-four patients has been completed, fifteen having finished the trial. The objective assessment of grip strength and articular index were comparable with the two drugs, but subjective assessment showed that relief of early morning stiffness was better with indomethacin, although pain relief was no different. Evidence so far available shows that ketoprofen is a useful anti-inflammatory analgesic drug which is well tolerated and that the use of a suppository may be helpful in a few patients who find the oral route unacceptable. A larger study is necessary to evaluate finally the use of a combined administration.

Administration, Oral↗
PubMed1978

Comparison of two maintenance schedules of chrysotherapy in rheumatoid arthritis: preliminary report.

Comparison of maintenance injections of sodium aurothiomalate given at two-week or four-week intervals revealed no significant clinical or radiological differences over a six-month period. Higher serum gold levels were achieved with the more frequent injections and these were associated with a more pronounced fall of ESR during maintenance therapy. Whether this has any special implications for the subsequent progress of patients treated by the two regimes remains to be determined.

Adult↗
PubMed1977

Gustav Simon (1824-1876): Simonart (s)(z) of the band?

Gustav Simon was the first to describe how, in a bilateral hare lip, the premaxilla would move backwards when the clefts were closed. The reference invariably given for this is wrong. The "bands" which Simon Arzt created to bridge the clefts and pull back the premaxilla are almost certainly the origin of the term "Simonart's(s')(z') band.

Cleft Lip↗
PubMed1977

Dysphagia due to vertical subluxation of the axis in rheumatoid arthritis.

Two patients with rheumatoid arthritis developed swallowing difficulties. These were mild in one case but severe in the other. Associated pyramidal tract signs and striking upward translocation of the dens made it seem probable that dysphagia was attributable to medullary compression despite the absence of other bulbar features. A history of dysphagia may therefore have serious implications for patients with rheumatoid disease.

Arthritis, Rheumatoid↗
PubMed1977

Effect of intra-articular corticosteroid injections on primate cartilage.

An attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. The knee joints of 10 Macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. Minor degenerative changes of many femoral condyles were shown by India ink staining and by a system of histochemical grading. Changes in the joints injected with corticosteroid were not significantly different from those seen in control joints. The findings were in striking contrast to the severe degeneration reported by others in rabbit joints injected with corticosteroid. The experiment did not support the contention that intra-articular corticosteroids invariably have a deleterious effect on primate cartilage.

Animals↗
PubMed1976

Ankylosing hyperostosis with cervical spinal cord compression.

This report describes a patient whose clinical and radiological features conform to those of ankylosing hyperostosis. Posterior bridging osteophytes were also apparent and these have not been previously described in ankylosing hyperostosis. We have considered alternative explanations for this finding and concluded that they were manifestations of the hyperostotic process. This unusual feature occurring in the presence of a comparatively narrow spinal canal resulted in cord compression and a spastic tetraparesis and we would therefore suggest that ankylosing hyperostosis may sometimes have serious neurological consequences.

Aged↗
PubMed1976

Hypouricaemia and increased renal urate clearance associated with hyperparathyroidism.

A 64-year-old female was found to have hypouricaemia, with serum uric acid ranging from 0.06-0.12 mmol/l (1.1-2.0 mg/100 ml), associated with an increased urate clearance of 48.9 ml/min and hyperparathyroidism. Known causes of increased uric acid clearance were excluded. Pyrazinamide reduced urate clearance dramatically to 2.1 ml/min, suggesting that the tubular defect was either one of increased secretion or a failure of postsecretory reabsorption. No other tubular abnormality was apparent except diminished urine concentrating ability. Hypouricaemia has not been previously reported in association with hyperparathyroidism and a mechanism relating the two disorders could not be readily postulated. The tubular defect shown in this instance resembled that reported in association with Wilson's disease and Hodgkin's disease. This case and earlier reports of isolated tubular defects of uric acid handling enhance our understanding of uric acid excretion.

Depression, Chemical↗
PubMed1976

Two kindred with the rare dominant inhibitor of the lutheran and p1 red cell antigens.

Two kindred each showing the dominant inheritance of the rare phenotype lu(a-b-) in the Lutheran blood group system are recorded. The pedigrees illustrate the expected upset in the occurrence of the P1 antigen in the Lu(a-b-) members. A third Lu(a-b-) propositus of the dominant type was found after testing a further 3,197 donors on the East Anglian panel. The phenotype Lu(a-b-) may not be quite as rare as previously supposed.

Blood Group Antigens↗